Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone

The conformation-activity relationships for the biologically active polyketide, epothilone, have been determined. Computer-based molecular modeling and high field NMR techniques have provided the solution preferences for epothilones and. For the C1-C8 polypropionate region, two conformational famili...

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Veröffentlicht in:	Organic & biomolecular chemistry 2004-01, Vol.2 (1), p.127-132
Hauptverfasser:	Taylor, Richard E, Chen, Yue, Galvin, Gabriel M, Pabba, Praveen K
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Epothilones - chemistry Epothilones - pharmacology Molecular Conformation Structure-Activity Relationship
Online-Zugang:	Volltext
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