Tuberculosis in patients with various HLA phenotypes
Tuberculosis patients and healthy subjects from six ethnic groups of the Soviet Union were HLA-A, -B, -C, and DR typed. The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency...
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| Veröffentlicht in: | Tubercle 1990-09, Vol.71 (3), p.187-192 |
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| creator | Khomenko, A.G. Litvinov, V.I. Chukanova, V.P. Pospelov, L.E. |
| description | Tuberculosis patients and healthy subjects from six ethnic groups of the Soviet Union were HLA-A, -B, -C, and DR typed. The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency of HLA-DR2 and a reduced frequency of HLADR3 type. Unfavourable dynamics of tuberculosis was significantly associated with an increased incidence of B15 and DR2 and a reduced incidence of B27 and DR3. Family studies revealed that the inheritance of susceptibility to tuberculosis (from parent to offspring) is associated with the inheritance of certain HLA haplotypes. Tuberculosis patients bearing the DR2 antigen had increased levels of IgG antibodies to PPD and the frequency of B7 and, more particularly, DR2 was higher in anergic patients. |
| doi_str_mv | 10.1016/0041-3879(90)90074-I |
| format | Article |
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The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency of HLA-DR2 and a reduced frequency of HLADR3 type. Unfavourable dynamics of tuberculosis was significantly associated with an increased incidence of B15 and DR2 and a reduced incidence of B27 and DR3. Family studies revealed that the inheritance of susceptibility to tuberculosis (from parent to offspring) is associated with the inheritance of certain HLA haplotypes. Tuberculosis patients bearing the DR2 antigen had increased levels of IgG antibodies to PPD and the frequency of B7 and, more particularly, DR2 was higher in anergic patients.</description><identifier>ISSN: 0041-3879</identifier><identifier>DOI: 10.1016/0041-3879(90)90074-I</identifier><identifier>PMID: 2238125</identifier><identifier>CODEN: TUBEAS</identifier><language>eng</language><publisher>Harlow: Elsevier Ltd</publisher><subject>Antibodies, Bacterial - analysis ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Disease Susceptibility ; HLA Antigens - analysis ; HLA-B Antigens - analysis ; HLA-DR Antigens - analysis ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Phenotype ; Prognosis ; Tuberculin - immunology ; Tuberculosis, Pulmonary - ethnology ; Tuberculosis, Pulmonary - genetics ; Tuberculosis, Pulmonary - immunology ; USSR</subject><ispartof>Tubercle, 1990-09, Vol.71 (3), p.187-192</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-68e7c3291d7a0c22f67e502e94da23abab50ed356ce4e56c6b24a5ff00d010233</citedby><cites>FETCH-LOGICAL-c387t-68e7c3291d7a0c22f67e502e94da23abab50ed356ce4e56c6b24a5ff00d010233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19527419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2238125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khomenko, A.G.</creatorcontrib><creatorcontrib>Litvinov, V.I.</creatorcontrib><creatorcontrib>Chukanova, V.P.</creatorcontrib><creatorcontrib>Pospelov, L.E.</creatorcontrib><title>Tuberculosis in patients with various HLA phenotypes</title><title>Tubercle</title><addtitle>Tubercle</addtitle><description>Tuberculosis patients and healthy subjects from six ethnic groups of the Soviet Union were HLA-A, -B, -C, and DR typed. The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency of HLA-DR2 and a reduced frequency of HLADR3 type. Unfavourable dynamics of tuberculosis was significantly associated with an increased incidence of B15 and DR2 and a reduced incidence of B27 and DR3. Family studies revealed that the inheritance of susceptibility to tuberculosis (from parent to offspring) is associated with the inheritance of certain HLA haplotypes. Tuberculosis patients bearing the DR2 antigen had increased levels of IgG antibodies to PPD and the frequency of B7 and, more particularly, DR2 was higher in anergic patients.</description><subject>Antibodies, Bacterial - analysis</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Disease Susceptibility</subject><subject>HLA Antigens - analysis</subject><subject>HLA-B Antigens - analysis</subject><subject>HLA-DR Antigens - analysis</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Tuberculin - immunology</subject><subject>Tuberculosis, Pulmonary - ethnology</subject><subject>Tuberculosis, Pulmonary - genetics</subject><subject>Tuberculosis, Pulmonary - immunology</subject><subject>USSR</subject><issn>0041-3879</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhnMAjTH4ByD1AoJDwUnTj1yQpgnYpElcxjlKU1cL6tqStJv278lYNW74YEv269fWQ8gNhScKNHkG4DSMslQ8CHgUACkPF2dkfGpfkEvnvgBYxpNsREaMRRll8ZjwVZ-j1X3VOOMCUwet6gzWnQt2plsHW2VN07tgvpwG7Rrrptu36K7Ieakqh9dDnZDPt9fVbB4uP94Xs-ky1P5mFyYZpjpighapAs1YmaQYA0PBC8Uilas8BiyiONHI0eckZ1zFZQlQAAUWRRNyf_RtbfPdo-vkxjiNVaVq9F_JDKgPAV7Ij0JtG-cslrK1ZqPsXlKQB0DyQEIeSEgB8heQXPi128G_zzdYnJYGOn5-N8yV06oqraq1cX_eImYpp8LrXo469DC2Bq102kPUWBiLupNFY_5_5AfqioMN</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Khomenko, A.G.</creator><creator>Litvinov, V.I.</creator><creator>Chukanova, V.P.</creator><creator>Pospelov, L.E.</creator><general>Elsevier Ltd</general><general>Livingstone</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Tuberculosis in patients with various HLA phenotypes</title><author>Khomenko, A.G. ; Litvinov, V.I. ; Chukanova, V.P. ; Pospelov, L.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-68e7c3291d7a0c22f67e502e94da23abab50ed356ce4e56c6b24a5ff00d010233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antibodies, Bacterial - analysis</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Biological and medical sciences</topic><topic>Disease Susceptibility</topic><topic>HLA Antigens - analysis</topic><topic>HLA-B Antigens - analysis</topic><topic>HLA-DR Antigens - analysis</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Tuberculin - immunology</topic><topic>Tuberculosis, Pulmonary - ethnology</topic><topic>Tuberculosis, Pulmonary - genetics</topic><topic>Tuberculosis, Pulmonary - immunology</topic><topic>USSR</topic><toplevel>online_resources</toplevel><creatorcontrib>Khomenko, A.G.</creatorcontrib><creatorcontrib>Litvinov, V.I.</creatorcontrib><creatorcontrib>Chukanova, V.P.</creatorcontrib><creatorcontrib>Pospelov, L.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tubercle</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khomenko, A.G.</au><au>Litvinov, V.I.</au><au>Chukanova, V.P.</au><au>Pospelov, L.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculosis in patients with various HLA phenotypes</atitle><jtitle>Tubercle</jtitle><addtitle>Tubercle</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>71</volume><issue>3</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>0041-3879</issn><coden>TUBEAS</coden><abstract>Tuberculosis patients and healthy subjects from six ethnic groups of the Soviet Union were HLA-A, -B, -C, and DR typed. The frequencies of the HLA-A, -B and -C antigens differed amongst the ethnic groups. With all groups, however, patients with tuberculosis showed a significantly increased frequency of HLA-DR2 and a reduced frequency of HLADR3 type. Unfavourable dynamics of tuberculosis was significantly associated with an increased incidence of B15 and DR2 and a reduced incidence of B27 and DR3. Family studies revealed that the inheritance of susceptibility to tuberculosis (from parent to offspring) is associated with the inheritance of certain HLA haplotypes. Tuberculosis patients bearing the DR2 antigen had increased levels of IgG antibodies to PPD and the frequency of B7 and, more particularly, DR2 was higher in anergic patients.</abstract><cop>Harlow</cop><pub>Elsevier Ltd</pub><pmid>2238125</pmid><doi>10.1016/0041-3879(90)90074-I</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibodies, Bacterial - analysis Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Disease Susceptibility HLA Antigens - analysis HLA-B Antigens - analysis HLA-DR Antigens - analysis Human bacterial diseases Humans Infectious diseases Medical sciences Phenotype Prognosis Tuberculin - immunology Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology USSR |
| title | Tuberculosis in patients with various HLA phenotypes |
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