Reagents for Astatination of Biomolecules: Comparison of the in Vivo Distribution and Stability of Some Radioiodinated/Astatinated Benzamidyl and nido-Carboranyl Compounds

An investigation has been conducted to assess the in vivo stability of a series of astatinated benzamides and astatinated nido-carborane compounds in mice. It was hypothesized that the higher bond strength of boron−astatine bonds in the nido-carboranes might provide increased stability toward in viv...

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Veröffentlicht in:	Bioconjugate chemistry 2004-01, Vol.15 (1), p.203-223
Hauptverfasser:	Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K, Kegley, Brian B, Risler, Reudi, Pathare, Pradip M, Quinn, Janna, Vessella, Robert L, Foulon, Catherine, Zalutsky, Michael, Wedge, Timothy J, Hawthorne, M. Frederick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astatine - chemistry Astatine - pharmacokinetics Benzamides - chemical synthesis Benzamides - pharmacokinetics Drug Stability Indicators and Reagents Iodine Radioisotopes - pharmacokinetics Isotope Labeling Magnetic Resonance Spectroscopy Mice Mice, Inbred BALB C Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Spectrophotometry, Ultraviolet Tissue Distribution
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