A Glycopolymer Chaperone for Fibroblast Growth Factor-2

Mono- and disaccharide-containing glycopolymers were synthesized by cyanoxyl-mediated polymerization of acrylamide with acrylate-derivatized mono- and disaccharides. We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a...

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Veröffentlicht in:	Bioconjugate chemistry 2004-01, Vol.15 (1), p.145-151
Hauptverfasser:	Guan, Ran, Sun, Xue-Long, Hou, Sijian, Wu, Peiyi, Chaikof, Elliot L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Cell Division - drug effects Cells, Cultured chaperones Chromatography, Thin Layer Fibroblast Growth Factor 2 - chemistry glycopolymers heparan sulfate heparin Hot Temperature Hydrolysis Indicators and Reagents Mice Molecular Chaperones - chemical synthesis Molecular Chaperones - chemistry Molecular Mimicry Polymers - chemical synthesis Polymers - chemistry Receptor Protein-Tyrosine Kinases - drug effects Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - drug effects Receptors, Fibroblast Growth Factor - metabolism Solvents Trypsin
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