Snapshots of DsbA in Action: Detection of Proteins in the Process of Oxidative Folding

DsbA, a thioredoxin superfamily member, introduces disulfide bonds into newly translocated proteins. This process is thought to occur via formation of mixed disulfide complexes between DsbA and its substrates. However, these complexes are difficult to detect, probably because of their short-lived na...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-01, Vol.303 (5657), p.534-537
Hauptverfasser:	Kadokura, Hiroshi, Tian, Hongping, Zander, Thomas, James C. A. Bardwell, Beckwith, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Amino Acid Motifs Antibodies Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biological and medical sciences Chemical bonds Disulfides Disulfides - chemistry DsbA protein Electrophoresis Electrophoresis, Polyacrylamide Gel Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Family members Fundamental and applied biological sciences. Psychology Gels Identification and classification Isomerism Mass Spectrometry Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Microbiology Molecular and cellular biology Molecular genetics Molecular Weight Mutation Observations Oxidation Oxidation-Reduction Plasmids Proline - chemistry Protein Conformation Protein Disulfide-Isomerases - chemistry Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Protein Folding Proteins Thioredoxin Thioredoxins Thioredoxins - chemistry Thioredoxins - metabolism Transduction, Genetic Translation. Translation factors. Protein processing
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