Inhibition of Testicular Steroidogenesis by the Xenoestrogen Bisphenol A Is Associated with Reduced Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells

Exposure of humans to bisphenol A (BPA), a monomer in polycarbonate plastics and a constituent of resins used in food packaging and dentistry, is significant. In this report exposure of rats to 2.4 μg/kg·d (a dose that approximates BPA levels in the environment) from postnatal d 21–35 suppressed ser...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-02, Vol.145 (2), p.592-603
Hauptverfasser:	Akingbemi, Benson T, Sottas, Chantal M, Koulova, Anna I, Klinefelter, Gary R, Hardy, Matthew P
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Aging Androgens - biosynthesis Animals Animals, Newborn - growth & development Aromatase Aromatase - genetics Aromatase - metabolism Benzhydryl Compounds Biological and medical sciences Biosynthesis Bisphenol A Dentistry Dose-Response Relationship, Drug Enzymes Estradiol - blood Estrogen Receptor beta Estrogen receptors Estrogens Estrogens, Non-Steroidal - pharmacology Exposure Female Fertility Food packaging Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Human populations Leydig cells Leydig Cells - drug effects Leydig Cells - enzymology Luteinizing hormone Luteinizing Hormone - blood Luteinizing Hormone - secretion Luteinizing Hormone, beta Subunit - genetics Male Organ Size - drug effects Perinatal exposure Phenols - pharmacology Pituitary Pituitary Gland - drug effects Pituitary Gland - secretion Polycarbonate Population studies Postpartum period Pregnancy Rats Rats, Long-Evans Receptors, Estrogen - genetics Resins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Seminal Vesicles - growth & development Sex hormones Steroidogenesis Steroids - biosynthesis Testes Testis - embryology Testis - growth & development Testosterone Testosterone - biosynthesis Vertebrates: endocrinology
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