Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H+-adenosine triphosphatase
The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region,...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1990-11, Vol.250 (4981), p.651-657 |
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| creator | Kane, P.M. (University of Oregon, Eugene, OR) Yamashiro, C.T Wolczyk, D.F Neff, N Goebl, M Stevens, T.H |
| description | The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit |
| doi_str_mv | 10.1126/science.2146742 |
| format | Article |
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(University of Oregon, Eugene, OR) ; Yamashiro, C.T ; Wolczyk, D.F ; Neff, N ; Goebl, M ; Stevens, T.H</creator><creatorcontrib>Kane, P.M. (University of Oregon, Eugene, OR) ; Yamashiro, C.T ; Wolczyk, D.F ; Neff, N ; Goebl, M ; Stevens, T.H</creatorcontrib><description>The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2146742</identifier><identifier>PMID: 2146742</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adenosine triphosphatases ; ADENOSINE TRIPHOSPHATE ; ADENOSINTRIFOSFATO ; Amino acids ; Animals ; Antibodies ; Biochemistry ; Biological and medical sciences ; Cell growth ; Fundamental and applied biological sciences. Psychology ; GENE ; GENES ; Genes, Fungal ; Genetic aspects ; Genetics ; Messenger RNA ; Molecular and cellular biology ; Molecular genetics ; Monoclonal antibodies ; Plasmids ; Protein Biosynthesis ; Protein engineering ; Protein Processing, Post-Translational ; Proteins ; Proton-Translocating ATPases - biosynthesis ; Proton-Translocating ATPases - genetics ; Rabbits ; RNA ; RNA, Messenger - analysis ; SACCHAROMYCES CEREVISIAE ; Saccharomyces cerevisiae - enzymology ; Splicing ; Translation. Translation factors. Protein processing ; Vacuoles - enzymology ; Yeast ; Yeast (Food product) ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 1990-11, Vol.250 (4981), p.651-657</ispartof><rights>Copyright 1990 American Association for the Advancement of Science</rights><rights>1991 INIST-CNRS</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 2, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2878492$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2878492$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19416171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2146742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kane, P.M. (University of Oregon, Eugene, OR)</creatorcontrib><creatorcontrib>Yamashiro, C.T</creatorcontrib><creatorcontrib>Wolczyk, D.F</creatorcontrib><creatorcontrib>Neff, N</creatorcontrib><creatorcontrib>Goebl, M</creatorcontrib><creatorcontrib>Stevens, T.H</creatorcontrib><title>Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H+-adenosine triphosphatase</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit</description><subject>Adenosine triphosphatases</subject><subject>ADENOSINE TRIPHOSPHATE</subject><subject>ADENOSINTRIFOSFATO</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell growth</subject><subject>Fundamental and applied biological sciences. 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(University of Oregon, Eugene, OR)</au><au>Yamashiro, C.T</au><au>Wolczyk, D.F</au><au>Neff, N</au><au>Goebl, M</au><au>Stevens, T.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H+-adenosine triphosphatase</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1990-11-02</date><risdate>1990</risdate><volume>250</volume><issue>4981</issue><spage>651</spage><epage>657</epage><pages>651-657</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The TFP1 gene of the yeast Saccharomyces cerevisiae encodes two proteins: the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H+-ATPase) and a 50-kD protein. The 69-kD subunit is encoded by the 5' and 3' thirds of the TFP1 coding region, whereas the 50-kD protein is encoded by the central third. Evidence is presented that both the 69-kD and 50-kD proteins are obtained from a single translation product that is cleaved to release the 50-kD protein and spliced to form the 69-kD subunit</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>2146742</pmid><doi>10.1126/science.2146742</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1990-11, Vol.250 (4981), p.651-657 |
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| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; JSTOR |
| subjects | Adenosine triphosphatases ADENOSINE TRIPHOSPHATE ADENOSINTRIFOSFATO Amino acids Animals Antibodies Biochemistry Biological and medical sciences Cell growth Fundamental and applied biological sciences. Psychology GENE GENES Genes, Fungal Genetic aspects Genetics Messenger RNA Molecular and cellular biology Molecular genetics Monoclonal antibodies Plasmids Protein Biosynthesis Protein engineering Protein Processing, Post-Translational Proteins Proton-Translocating ATPases - biosynthesis Proton-Translocating ATPases - genetics Rabbits RNA RNA, Messenger - analysis SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - enzymology Splicing Translation. Translation factors. Protein processing Vacuoles - enzymology Yeast Yeast (Food product) Yeasts |
| title | Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H+-adenosine triphosphatase |
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