Valproate Potentiates Androgen Biosynthesis in Human Ovarian Theca Cells

In patients with epilepsy, treatment with valproate (VPA) has been reported to be associated with polycystic ovary syndrome-like symptoms including weight gain, hyperandrogenemia, and hyperinsulinemia. We examined the effect of VPA on androgen biosynthesis in ovarian theca cells isolated from follic...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-02, Vol.145 (2), p.799-808
Hauptverfasser:	Nelson-DeGrave, Velen L, Wickenheisser, Jessica K, Cockrell, Jennifer E, Wood, Jennifer R, Legro, Richard S, Strauss, Jerome F, McAllister, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	17-alpha-Hydroxyprogesterone - metabolism Acetylation Adult Androgens Androgens - biosynthesis Androstenedione Androstenedione - biosynthesis Biological and medical sciences Biosynthesis Bipolar disorder Butyric acid Cholesterol Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Chromatin Dehydroepiandrosterone Dehydroepiandrosterone - biosynthesis Epilepsy Female Follicles Forskolin Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Histone deacetylase Histone H3 Histones Histones - metabolism Humans Hyperinsulinemia Inhibitors Ovaries Phosphoproteins - genetics Phosphoproteins - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism Progesterone Progesterone - biosynthesis Proteins Sodium valproate Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Steroidogenic acute regulatory protein Theca Theca Cells - drug effects Theca Cells - metabolism Transfection Valproic acid Valproic Acid - pharmacology Vertebrates: endocrinology
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