Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee
Objective: To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA). Methods: Subjects were divided into three groups: without OA...
Gespeichert in:
| Veröffentlicht in: | Osteoarthritis and cartilage 2004-02, Vol.12 (2), p.86-96 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 96 |
|---|---|
| container_issue | 2 |
| container_start_page | 86 |
| container_title | Osteoarthritis and cartilage |
| container_volume | 12 |
| creator | Lindsey, C.T Narasimhan, A Adolfo, J.M Jin, Hua Steinbach, L.S Link, T Ries, M Majumdar, S |
| description | Objective: To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
Methods: Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234×0.234
mm
2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195×0.195
mm
2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
Results: Cartilage volume and thickness were less in patients with OA compared to normal controls (
P |
| doi_str_mv | 10.1016/j.joca.2003.10.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_80107097</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1063458403002747</els_id><sourcerecordid>80107097</sourcerecordid><originalsourceid>FETCH-LOGICAL-e260t-7551422be82dfc6e8ca5ebebdba03f6268d0d9591f33973efc92b1ba48d78b193</originalsourceid><addsrcrecordid>eNo1kclOHDEQhi1ExDLwAhyQT9x68NKLW-KCEAlIoFzC2fJSzXjosQfbPSjHvDnuDJyq9NdXi-pH6IKSJSW0vV4v18GoJSOEF2FJSH-ATmjDWNW3DT8sOWl5VTeiPkanKa1JASklR-iY1h3johUn6N-zevWQncERUvDKG8CwU-OksgsehwHnFWDnM8QI438xrdwWa8gfAB6rWHqnUUVs5nRUr4CVtzhHpWFf0MHD96CQMoQCrqKbd755gDP0Y1BjgvOvuEAvP-__3D1UT79_Pd7dPlXAWpKrrmlozZgGwexgWhBGNaBBW60IH1rWCkts3_R04LzvOAymZ5pqVQvbCU17vkBX-7nbGN4nSFluXDIwjspDmJIUhJKOlNYFuvwCJ70BK7fRbVT8K7-fVoCbPQDl3J2DKJNxUD5nXQSTpQ1OUiJnj-Razh7J2aNZKx7xT0yyh9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80107097</pqid></control><display><type>article</type><title>Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lindsey, C.T ; Narasimhan, A ; Adolfo, J.M ; Jin, Hua ; Steinbach, L.S ; Link, T ; Ries, M ; Majumdar, S</creator><creatorcontrib>Lindsey, C.T ; Narasimhan, A ; Adolfo, J.M ; Jin, Hua ; Steinbach, L.S ; Link, T ; Ries, M ; Majumdar, S</creatorcontrib><description>Objective: To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
Methods: Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234×0.234
mm
2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195×0.195
mm
2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
Results: Cartilage volume and thickness were less in patients with OA compared to normal controls (
P<0.1). Articular cartilage thinning is associated with bone structure loss in the opposite femoral condyle (
P<0.05). In varus OA, there were extensive correlations between medial tibia and medial femoral cartilage degeneration, and loss of bone structure in the lateral tibia and lateral condyle. Additional correlations existed between the compartmental differences (lateral minus medial) of cartilage thickness and bone structure.
Conclusion: Degradation of articular cartilage within a compartment correlates with a loss of bone structure in the opposite compartment. The correlation between the (L-M) differences corroborates this relationship. Malalignment of the knee due to cartilage degeneration is associated with bone formation in the diseased condyle and bone resorption in the opposite compartment.</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2003.10.009</identifier><identifier>PMID: 14723868</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age Factors ; Aged ; Cartilage Diseases - diagnosis ; Cartilage, Articular - pathology ; Female ; Femur - pathology ; Humans ; Image Processing, Computer-Assisted ; Knee ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Musculoskeletal ; Osteoarthritis ; Osteoarthritis, Knee - diagnosis ; Pain Measurement - methods ; Tibia - pathology</subject><ispartof>Osteoarthritis and cartilage, 2004-02, Vol.12 (2), p.86-96</ispartof><rights>2003 OsteoArthritis Research Society International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joca.2003.10.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14723868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindsey, C.T</creatorcontrib><creatorcontrib>Narasimhan, A</creatorcontrib><creatorcontrib>Adolfo, J.M</creatorcontrib><creatorcontrib>Jin, Hua</creatorcontrib><creatorcontrib>Steinbach, L.S</creatorcontrib><creatorcontrib>Link, T</creatorcontrib><creatorcontrib>Ries, M</creatorcontrib><creatorcontrib>Majumdar, S</creatorcontrib><title>Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Objective: To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
Methods: Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234×0.234
mm
2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195×0.195
mm
2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
Results: Cartilage volume and thickness were less in patients with OA compared to normal controls (
P<0.1). Articular cartilage thinning is associated with bone structure loss in the opposite femoral condyle (
P<0.05). In varus OA, there were extensive correlations between medial tibia and medial femoral cartilage degeneration, and loss of bone structure in the lateral tibia and lateral condyle. Additional correlations existed between the compartmental differences (lateral minus medial) of cartilage thickness and bone structure.
Conclusion: Degradation of articular cartilage within a compartment correlates with a loss of bone structure in the opposite compartment. The correlation between the (L-M) differences corroborates this relationship. Malalignment of the knee due to cartilage degeneration is associated with bone formation in the diseased condyle and bone resorption in the opposite compartment.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Cartilage Diseases - diagnosis</subject><subject>Cartilage, Articular - pathology</subject><subject>Female</subject><subject>Femur - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Knee</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Musculoskeletal</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - diagnosis</subject><subject>Pain Measurement - methods</subject><subject>Tibia - pathology</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kclOHDEQhi1ExDLwAhyQT9x68NKLW-KCEAlIoFzC2fJSzXjosQfbPSjHvDnuDJyq9NdXi-pH6IKSJSW0vV4v18GoJSOEF2FJSH-ATmjDWNW3DT8sOWl5VTeiPkanKa1JASklR-iY1h3johUn6N-zevWQncERUvDKG8CwU-OksgsehwHnFWDnM8QI438xrdwWa8gfAB6rWHqnUUVs5nRUr4CVtzhHpWFf0MHD96CQMoQCrqKbd755gDP0Y1BjgvOvuEAvP-__3D1UT79_Pd7dPlXAWpKrrmlozZgGwexgWhBGNaBBW60IH1rWCkts3_R04LzvOAymZ5pqVQvbCU17vkBX-7nbGN4nSFluXDIwjspDmJIUhJKOlNYFuvwCJ70BK7fRbVT8K7-fVoCbPQDl3J2DKJNxUD5nXQSTpQ1OUiJnj-Razh7J2aNZKx7xT0yyh9A</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Lindsey, C.T</creator><creator>Narasimhan, A</creator><creator>Adolfo, J.M</creator><creator>Jin, Hua</creator><creator>Steinbach, L.S</creator><creator>Link, T</creator><creator>Ries, M</creator><creator>Majumdar, S</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee</title><author>Lindsey, C.T ; Narasimhan, A ; Adolfo, J.M ; Jin, Hua ; Steinbach, L.S ; Link, T ; Ries, M ; Majumdar, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e260t-7551422be82dfc6e8ca5ebebdba03f6268d0d9591f33973efc92b1ba48d78b193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Cartilage Diseases - diagnosis</topic><topic>Cartilage, Articular - pathology</topic><topic>Female</topic><topic>Femur - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Knee</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Musculoskeletal</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - diagnosis</topic><topic>Pain Measurement - methods</topic><topic>Tibia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindsey, C.T</creatorcontrib><creatorcontrib>Narasimhan, A</creatorcontrib><creatorcontrib>Adolfo, J.M</creatorcontrib><creatorcontrib>Jin, Hua</creatorcontrib><creatorcontrib>Steinbach, L.S</creatorcontrib><creatorcontrib>Link, T</creatorcontrib><creatorcontrib>Ries, M</creatorcontrib><creatorcontrib>Majumdar, S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindsey, C.T</au><au>Narasimhan, A</au><au>Adolfo, J.M</au><au>Jin, Hua</au><au>Steinbach, L.S</au><au>Link, T</au><au>Ries, M</au><au>Majumdar, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>12</volume><issue>2</issue><spage>86</spage><epage>96</epage><pages>86-96</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Objective: To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
Methods: Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234×0.234
mm
2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195×0.195
mm
2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
Results: Cartilage volume and thickness were less in patients with OA compared to normal controls (
P<0.1). Articular cartilage thinning is associated with bone structure loss in the opposite femoral condyle (
P<0.05). In varus OA, there were extensive correlations between medial tibia and medial femoral cartilage degeneration, and loss of bone structure in the lateral tibia and lateral condyle. Additional correlations existed between the compartmental differences (lateral minus medial) of cartilage thickness and bone structure.
Conclusion: Degradation of articular cartilage within a compartment correlates with a loss of bone structure in the opposite compartment. The correlation between the (L-M) differences corroborates this relationship. Malalignment of the knee due to cartilage degeneration is associated with bone formation in the diseased condyle and bone resorption in the opposite compartment.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>14723868</pmid><doi>10.1016/j.joca.2003.10.009</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1063-4584 |
| ispartof | Osteoarthritis and cartilage, 2004-02, Vol.12 (2), p.86-96 |
| issn | 1063-4584 1522-9653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80107097 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Cartilage Diseases - diagnosis Cartilage, Articular - pathology Female Femur - pathology Humans Image Processing, Computer-Assisted Knee Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Male Middle Aged Musculoskeletal Osteoarthritis Osteoarthritis, Knee - diagnosis Pain Measurement - methods Tibia - pathology |
| title | Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T09%3A16%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20resonance%20evaluation%20of%20the%20interrelationship%20between%20articular%20cartilage%20and%20trabecular%20bone%20of%20the%20osteoarthritic%20knee&rft.jtitle=Osteoarthritis%20and%20cartilage&rft.au=Lindsey,%20C.T&rft.date=2004-02-01&rft.volume=12&rft.issue=2&rft.spage=86&rft.epage=96&rft.pages=86-96&rft.issn=1063-4584&rft.eissn=1522-9653&rft_id=info:doi/10.1016/j.joca.2003.10.009&rft_dat=%3Cproquest_pubme%3E80107097%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80107097&rft_id=info:pmid/14723868&rft_els_id=S1063458403002747&rfr_iscdi=true |