Regional differences in the early mucosal immune response induced by primary inoculation of mice with respiratory syncytial virus
Respiratory syncytial virus (RSV) is the most important cause of respiratory tract infection in infants. Little is known about the characteristics of critical immunologic inductive sites within respiratory-associated lymphoid tissues (RALT) upon RSV infection. We examined the kinetics and characteri...
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| Veröffentlicht in: | Microbial pathogenesis 2004-03, Vol.36 (3), p.141-146 |
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| creator | Hishiki, Haruka Zuercher, Adrian W. Valosky, Janine Coffin, Susan E. |
| description | Respiratory syncytial virus (RSV) is the most important cause of respiratory tract infection in infants. Little is known about the characteristics of critical immunologic inductive sites within respiratory-associated lymphoid tissues (RALT) upon RSV infection. We examined the kinetics and characteristics of early mucosal RSV-specific immune responses after primary inoculation of mice. We found that the initial production of virus-specific antibodies was restricted to the organized lymphoid tissues of RALT, such as nasal-associated lymphoid tissue (NALT), cervical and bronchial lymph nodes (CLN and BLN). In addition, virus-specific IgM was produced by B cells resident in CLN and BLN, but not NALT, of mice. Finally, we observed regional differences in the pattern of RSV-specific antibodies produced by RALT; B cells within NALT and CLN produced equivalent quantities of virus-specific IgG2a and IgG2b. However, an IgG2a response predominated in BLN. Together these data demonstrate regional differences in the early mucosal immune response to RSV. Further understanding of these differences may assist the development of RSV vaccines. |
| doi_str_mv | 10.1016/j.micpath.2003.10.007 |
| format | Article |
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Little is known about the characteristics of critical immunologic inductive sites within respiratory-associated lymphoid tissues (RALT) upon RSV infection. We examined the kinetics and characteristics of early mucosal RSV-specific immune responses after primary inoculation of mice. We found that the initial production of virus-specific antibodies was restricted to the organized lymphoid tissues of RALT, such as nasal-associated lymphoid tissue (NALT), cervical and bronchial lymph nodes (CLN and BLN). In addition, virus-specific IgM was produced by B cells resident in CLN and BLN, but not NALT, of mice. Finally, we observed regional differences in the pattern of RSV-specific antibodies produced by RALT; B cells within NALT and CLN produced equivalent quantities of virus-specific IgG2a and IgG2b. However, an IgG2a response predominated in BLN. Together these data demonstrate regional differences in the early mucosal immune response to RSV. Further understanding of these differences may assist the development of RSV vaccines.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2003.10.007</identifier><identifier>PMID: 14726231</identifier><identifier>CODEN: MIPAEV</identifier><language>eng</language><publisher>Oxford: Elsevier India Pvt Ltd</publisher><subject>Animals ; Antibodies ; Antibodies, Viral - biosynthesis ; B-Lymphocytes - immunology ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Immunity ; Immunity, Mucosal ; Immunoglobulin G - biosynthesis ; Immunoglobulin M - biosynthesis ; Lymph Nodes - immunology ; Lymphoid Tissue - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; Respiratory Mucosa - immunology ; Respiratory Mucosa - virology ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Viruses - immunology ; Respiratory System - immunology ; Respiratory System - virology ; Respiratory tract ; Viral infections ; Virology</subject><ispartof>Microbial pathogenesis, 2004-03, Vol.36 (3), p.141-146</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-dab642f6c9fd1cbae1480dc2ece5a80dac9dfdc935c2640050f5f2674092a8163</citedby><cites>FETCH-LOGICAL-c422t-dab642f6c9fd1cbae1480dc2ece5a80dac9dfdc935c2640050f5f2674092a8163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2003.10.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15554307$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14726231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hishiki, Haruka</creatorcontrib><creatorcontrib>Zuercher, Adrian W.</creatorcontrib><creatorcontrib>Valosky, Janine</creatorcontrib><creatorcontrib>Coffin, Susan E.</creatorcontrib><title>Regional differences in the early mucosal immune response induced by primary inoculation of mice with respiratory syncytial virus</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Respiratory syncytial virus (RSV) is the most important cause of respiratory tract infection in infants. Little is known about the characteristics of critical immunologic inductive sites within respiratory-associated lymphoid tissues (RALT) upon RSV infection. We examined the kinetics and characteristics of early mucosal RSV-specific immune responses after primary inoculation of mice. We found that the initial production of virus-specific antibodies was restricted to the organized lymphoid tissues of RALT, such as nasal-associated lymphoid tissue (NALT), cervical and bronchial lymph nodes (CLN and BLN). In addition, virus-specific IgM was produced by B cells resident in CLN and BLN, but not NALT, of mice. Finally, we observed regional differences in the pattern of RSV-specific antibodies produced by RALT; B cells within NALT and CLN produced equivalent quantities of virus-specific IgG2a and IgG2b. However, an IgG2a response predominated in BLN. Together these data demonstrate regional differences in the early mucosal immune response to RSV. Further understanding of these differences may assist the development of RSV vaccines.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Respiratory Mucosa - immunology</subject><subject>Respiratory Mucosa - virology</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Viruses - immunology</subject><subject>Respiratory System - immunology</subject><subject>Respiratory System - virology</subject><subject>Respiratory tract</subject><subject>Viral infections</subject><subject>Virology</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1r3DAQxUVpaLZp_4QWXdqbtyNZ_jqVEvoFgUJJzkI7GnW12NZWslN8zH9ebdaQY04aht97Gt5j7J2ArQBRfzpsB49HM-23EqDMuy1A84JtBHR1ISS0L9kG2lYWCgRcstcpHQCgU2X3il0K1chalmLDHn7THx9G03PrnaNII1LifuTTnjiZ2C98mDGkDPhhmEfikdIxjIkyZGcky3cLP0Y_mLjkVcC5N1N25MHxfCHxf37aP4p8NFPIUFpGXCafHe99nNMbduFMn-jt-l6xu29fb69_FDe_vv-8_nJToJJyKqzZ1Uq6GjtnBe4MCdWCRUlIlcmTwc46i11ZoawVQAWucrJuFHTStKIur9jHs-8xhr8zpUkPPiH1vRkpzEm3Oaeq6dpnQdF0pWqUymB1BjGGlCI5veagBehTSfqg15L0qaTTOpeUde_XD-bdQPZJtbaSgQ8rYBKa3kUzok9PXFVVqnw0-nzmKOd27ynqhP7UoPWRcNI2-GdO-Q8xbLYp</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Hishiki, Haruka</creator><creator>Zuercher, Adrian W.</creator><creator>Valosky, Janine</creator><creator>Coffin, Susan E.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Regional differences in the early mucosal immune response induced by primary inoculation of mice with respiratory syncytial virus</title><author>Hishiki, Haruka ; Zuercher, Adrian W. ; Valosky, Janine ; Coffin, Susan E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-dab642f6c9fd1cbae1480dc2ece5a80dac9dfdc935c2640050f5f2674092a8163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunity</topic><topic>Immunity, Mucosal</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Respiratory Mucosa - immunology</topic><topic>Respiratory Mucosa - virology</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Viruses - immunology</topic><topic>Respiratory System - immunology</topic><topic>Respiratory System - virology</topic><topic>Respiratory tract</topic><topic>Viral infections</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hishiki, Haruka</creatorcontrib><creatorcontrib>Zuercher, Adrian W.</creatorcontrib><creatorcontrib>Valosky, Janine</creatorcontrib><creatorcontrib>Coffin, Susan E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hishiki, Haruka</au><au>Zuercher, Adrian W.</au><au>Valosky, Janine</au><au>Coffin, Susan E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional differences in the early mucosal immune response induced by primary inoculation of mice with respiratory syncytial virus</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>36</volume><issue>3</issue><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>0882-4010</issn><eissn>1096-1208</eissn><coden>MIPAEV</coden><abstract>Respiratory syncytial virus (RSV) is the most important cause of respiratory tract infection in infants. Little is known about the characteristics of critical immunologic inductive sites within respiratory-associated lymphoid tissues (RALT) upon RSV infection. We examined the kinetics and characteristics of early mucosal RSV-specific immune responses after primary inoculation of mice. We found that the initial production of virus-specific antibodies was restricted to the organized lymphoid tissues of RALT, such as nasal-associated lymphoid tissue (NALT), cervical and bronchial lymph nodes (CLN and BLN). In addition, virus-specific IgM was produced by B cells resident in CLN and BLN, but not NALT, of mice. Finally, we observed regional differences in the pattern of RSV-specific antibodies produced by RALT; B cells within NALT and CLN produced equivalent quantities of virus-specific IgG2a and IgG2b. However, an IgG2a response predominated in BLN. Together these data demonstrate regional differences in the early mucosal immune response to RSV. 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| subjects | Animals Antibodies Antibodies, Viral - biosynthesis B-Lymphocytes - immunology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Immunity Immunity, Mucosal Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Lymph Nodes - immunology Lymphoid Tissue - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous Respiratory Mucosa - immunology Respiratory Mucosa - virology Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Viruses - immunology Respiratory System - immunology Respiratory System - virology Respiratory tract Viral infections Virology |
| title | Regional differences in the early mucosal immune response induced by primary inoculation of mice with respiratory syncytial virus |
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