Bolaforms with Fourteen Galactose Units:  A Proposed Site-Directed Cohesion of Cancer Cells

The multistep synthesis of a calixarene joined to a second calixarene via a long spacer is described. Since each calixarene bears multiple galactose-based units (known to bind strongly to rat hepatoma cells), there existed the possibility of cross-linking the cancer cells into a network. The compoun...

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Veröffentlicht in:	Organic letters 2004-01, Vol.6 (2), p.261-264
Hauptverfasser:	Menger, Fredric M, Bian, Jianwei, Sizova, Elena, Martinson, Deborah E, Seredyuk, Victor A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Calixarenes - chemical synthesis Calixarenes - pharmacology Cell Line, Tumor Drug Screening Assays, Antitumor Galactose - chemistry Molecular Structure Rats
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