Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats
Salmon pancreatic polypeptide (sPP) is a 36 residue peptide amide isolated from salmon pancreas. It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc sol...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1990-07, Vol.11 (4), p.673-677 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Balasubramaniam, A. Rigel, D.F. Chance, W.T. Stein, M. Fischer, J.E. King, D. Plisetskaya, E.M. |
| description | Salmon pancreatic polypeptide (sPP) is a 36 residue peptide amide isolated from salmon pancreas. It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc solid phase synthesis. The purified product had the expected amino acid composition, primary structure and mass, and was chemically and biologically indistinguishable from natural sPP. Investigation of its biological properties revealed that, like NPY, sPP increased blood pressure and decreased heart rate in anesthetized rats in a dose-dependent manner. There was no significant difference in the responses of NPY and sPP. Furthermore, administration of sPP directly into the hypothalamus of rats induced a feeding response comparable to that induced by NPY. Based on these investigations it may be suggested that synthetic and natural sPP are identical, and that sPP can express NPY-like activities in mammals presumably by interacting with the receptors of NPY. |
| doi_str_mv | 10.1016/0196-9781(90)90178-8 |
| format | Article |
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It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc solid phase synthesis. The purified product had the expected amino acid composition, primary structure and mass, and was chemically and biologically indistinguishable from natural sPP. Investigation of its biological properties revealed that, like NPY, sPP increased blood pressure and decreased heart rate in anesthetized rats in a dose-dependent manner. There was no significant difference in the responses of NPY and sPP. Furthermore, administration of sPP directly into the hypothalamus of rats induced a feeding response comparable to that induced by NPY. Based on these investigations it may be suggested that synthetic and natural sPP are identical, and that sPP can express NPY-like activities in mammals presumably by interacting with the receptors of NPY.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(90)90178-8</identifier><identifier>PMID: 2235676</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Eating - drug effects ; Endocrine pancreas ; Feeding ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Hormones. Régulation ; Hypothalamus - drug effects ; Male ; Molecular Sequence Data ; Neuropeptide Y ; Neuropeptide Y - pharmacology ; Pancreatic polypeptide ; Pancreatic Polypeptide - pharmacology ; Rats ; Rats, Inbred Strains ; Salmon ; Sequence Homology, Nucleic Acid ; Solid phase synthesis ; Vasoconstrictor activity ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 1990-07, Vol.11 (4), p.673-677</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c9fa1eb5e44b797233e138d4bb73186f6e6bba6d6c4d21d68cf0a22d9d1431c93</citedby><cites>FETCH-LOGICAL-c417t-c9fa1eb5e44b797233e138d4bb73186f6e6bba6d6c4d21d68cf0a22d9d1431c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(90)90178-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6948354$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2235676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balasubramaniam, A.</creatorcontrib><creatorcontrib>Rigel, D.F.</creatorcontrib><creatorcontrib>Chance, W.T.</creatorcontrib><creatorcontrib>Stein, M.</creatorcontrib><creatorcontrib>Fischer, J.E.</creatorcontrib><creatorcontrib>King, D.</creatorcontrib><creatorcontrib>Plisetskaya, E.M.</creatorcontrib><title>Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Salmon pancreatic polypeptide (sPP) is a 36 residue peptide amide isolated from salmon pancreas. It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc solid phase synthesis. The purified product had the expected amino acid composition, primary structure and mass, and was chemically and biologically indistinguishable from natural sPP. Investigation of its biological properties revealed that, like NPY, sPP increased blood pressure and decreased heart rate in anesthetized rats in a dose-dependent manner. There was no significant difference in the responses of NPY and sPP. Furthermore, administration of sPP directly into the hypothalamus of rats induced a feeding response comparable to that induced by NPY. Based on these investigations it may be suggested that synthetic and natural sPP are identical, and that sPP can express NPY-like activities in mammals presumably by interacting with the receptors of NPY.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Eating - drug effects</subject><subject>Endocrine pancreas</subject><subject>Feeding</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Hormones. Régulation</subject><subject>Hypothalamus - drug effects</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Neuropeptide Y</subject><subject>Neuropeptide Y - pharmacology</subject><subject>Pancreatic polypeptide</subject><subject>Pancreatic Polypeptide - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Salmon</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Solid phase synthesis</subject><subject>Vasoconstrictor activity</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3TAQhS3UCi4_b0ClLKoKFgFP7Dj2plKFgFaiYkG76Mpy7IkwzV9tB5W3J-lN77JdjTTznaPRR8gp0AugIC4pKJGrSsKZoueKQiVzuUc2ICuWlyDUG7LZIQfkMMYnSinnSu6T_aJgpajEhnx9MG039NloehvQJG-zcWhfRhyTd5jh70df-xSzHqcw_N3-yFv_EzNjk3_2yWPMfJ8Fk-IxeduYNuLJOo_I95vrb1ef87v72y9Xn-5yy6FKuVWNAaxL5LyuVFUwhsCk43VdMZCiESjq2ggnLHcFOCFtQ01ROOWAM7CKHZEP294xDL8mjEl3PlpsW9PjMEUtKdCyYPy_IJQLWiyNfAvaMMQYsNFj8J0JLxqoXnTrxaVeXGpF9R_dWs6xd2v_VHfodqHV73x_v95NtKZtwqzZxx0mFJesXN78uMVwlvbsMehoPfYWnQ9ok3aD__cfr4yPnCQ</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Balasubramaniam, A.</creator><creator>Rigel, D.F.</creator><creator>Chance, W.T.</creator><creator>Stein, M.</creator><creator>Fischer, J.E.</creator><creator>King, D.</creator><creator>Plisetskaya, E.M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats</title><author>Balasubramaniam, A. ; Rigel, D.F. ; Chance, W.T. ; Stein, M. ; Fischer, J.E. ; King, D. ; Plisetskaya, E.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c9fa1eb5e44b797233e138d4bb73186f6e6bba6d6c4d21d68cf0a22d9d1431c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Eating - drug effects</topic><topic>Endocrine pancreas</topic><topic>Feeding</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Hormones. Régulation</topic><topic>Hypothalamus - drug effects</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Neuropeptide Y</topic><topic>Neuropeptide Y - pharmacology</topic><topic>Pancreatic polypeptide</topic><topic>Pancreatic Polypeptide - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Salmon</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Solid phase synthesis</topic><topic>Vasoconstrictor activity</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balasubramaniam, A.</creatorcontrib><creatorcontrib>Rigel, D.F.</creatorcontrib><creatorcontrib>Chance, W.T.</creatorcontrib><creatorcontrib>Stein, M.</creatorcontrib><creatorcontrib>Fischer, J.E.</creatorcontrib><creatorcontrib>King, D.</creatorcontrib><creatorcontrib>Plisetskaya, E.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balasubramaniam, A.</au><au>Rigel, D.F.</au><au>Chance, W.T.</au><au>Stein, M.</au><au>Fischer, J.E.</au><au>King, D.</au><au>Plisetskaya, E.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>11</volume><issue>4</issue><spage>673</spage><epage>677</epage><pages>673-677</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Salmon pancreatic polypeptide (sPP) is a 36 residue peptide amide isolated from salmon pancreas. It has 83% sequence identity with porcine neuropeptide Y (NPY). To confirm the sequence and obtain sufficient quantity of peptide for biological investigations, sPP was synthesized by automated t-Boc solid phase synthesis. The purified product had the expected amino acid composition, primary structure and mass, and was chemically and biologically indistinguishable from natural sPP. Investigation of its biological properties revealed that, like NPY, sPP increased blood pressure and decreased heart rate in anesthetized rats in a dose-dependent manner. There was no significant difference in the responses of NPY and sPP. Furthermore, administration of sPP directly into the hypothalamus of rats induced a feeding response comparable to that induced by NPY. Based on these investigations it may be suggested that synthetic and natural sPP are identical, and that sPP can express NPY-like activities in mammals presumably by interacting with the receptors of NPY.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2235676</pmid><doi>10.1016/0196-9781(90)90178-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 1990-07, Vol.11 (4), p.673-677 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Blood Pressure - drug effects Eating - drug effects Endocrine pancreas Feeding Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hormones. Régulation Hypothalamus - drug effects Male Molecular Sequence Data Neuropeptide Y Neuropeptide Y - pharmacology Pancreatic polypeptide Pancreatic Polypeptide - pharmacology Rats Rats, Inbred Strains Salmon Sequence Homology, Nucleic Acid Solid phase synthesis Vasoconstrictor activity Vertebrates: endocrinology |
| title | Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats |
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