Development and characterization of a novel liposome-based formulation of SN-38

SN-38, 7-ethyl-10-hydroxycamptothecin, is the active metabolite of Irinotecan (CPT-11), a topoisomerase I inhibitor commercially available as Camptosar ®. SN-38 is approximately 200–2000-fold more cytotoxic than CPT-11. Despite its promising anticancer potential, SN-38 thus far has not been used as...

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Veröffentlicht in:	International journal of pharmaceutics 2004-02, Vol.270 (1), p.93-107
Hauptverfasser:	Zhang, J.Allen, Xuan, Tong, Parmar, Manjeet, Ma, Lan, Ugwu, Sydney, Ali, Shahid, Ahmad, Imran
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-tumor activity Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - chemistry Camptothecin - pharmacology Cell Line, Tumor Chromatography, High Pressure Liquid CPT-11 Drug Stability Female General pharmacology Hydrogen-Ion Concentration Injections, Intravenous Irinotecan Liposomes Liposomes - chemistry Lyophilization Male Medical sciences Mice Mice, Inbred Strains Neoplasm Transplantation Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments SN-38 Stability Time Factors Transplantation, Heterologous
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