Changes in motor cortical excitability in humans following orally administered theophylline

The effects of theophylline on human corticospinal excitability were studied using transcranial magnetic stimulation (TMS) before and after double-blind oral administration of theophylline or placebo in 20 healthy volunteers. TMS measurements included resting and active motor threshold, silent perio...

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Veröffentlicht in:	Neuroscience letters 2004-01, Vol.355 (1), p.65-68
Hauptverfasser:	Nardone, R, Buffone, E, Covi, M, Lochner, P.G, Tezzon, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Administration, Oral Adolescent Adult Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Convulsants - pharmacology Double-Blind Method Down-Regulation - drug effects Down-Regulation - physiology Electric Stimulation - instrumentation Electric Stimulation - methods Evoked Potentials, Motor - drug effects Evoked Potentials, Motor - physiology Female Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology GABA-A Receptor Antagonists gamma-Aminobutyric Acid - metabolism Humans Magnetics Male Middle Aged Motor Cortex - drug effects Motor Cortex - physiology Muscle, Skeletal - innervation Muscle, Skeletal - physiology Neural Inhibition - drug effects Neural Inhibition - physiology Pyramidal Tracts - drug effects Pyramidal Tracts - physiology Reaction Time - drug effects Receptors, GABA-A - metabolism Reference Values Synaptic Transmission - drug effects Synaptic Transmission - physiology Theophylline Theophylline - pharmacology Transcranial magnetic stimulation Vertebrates: nervous system and sense organs γ-Aminobutyric acid
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Zusammenfassung:	The effects of theophylline on human corticospinal excitability were studied using transcranial magnetic stimulation (TMS) before and after double-blind oral administration of theophylline or placebo in 20 healthy volunteers. TMS measurements included resting and active motor threshold, silent period, intracortical inhibition (ICI), and intracortical facilitation. F-wave and compound muscle action potential (CMAP) were also measured. Theophylline produces a reduction in ICI, while other parameters of corticospinal excitability remained unaffected. Since ICI is thought to depend on GABA A intracortical inhibitory mechanisms, our data suggest that the increase of human motor cortex excitability is the result of a decrease in GABAergic transmission. Our results further support the hypothesis that theophylline might induce convulsions by inhibiting GABA A receptor binding.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2003.10.055