Expression of human placenta alkaline phosphatase in placenta during pregnancy
To clarify the expression of PLAP during the course of pregnancy, the amount of PLAP mRNA and its activity in normal placental villi were measured. Both PLAP and its mRNA were found in placentae of as early as 7 weeks of gestation, and they continued to increase throughout pregnancy. But they showed...
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| Veröffentlicht in: | Placenta (Eastbourne) 1990-07, Vol.11 (4), p.319-327 |
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| container_title | Placenta (Eastbourne) |
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| creator | Okamoto, Tomomitsu Seo, Hisao Mano, Hisao Furuhashi, Madoka Goto, Setsuko Tomoda, Yutaka Matsui, Nobuo |
| description | To clarify the expression of PLAP during the course of pregnancy, the amount of PLAP mRNA and its activity in normal placental villi were measured. Both PLAP and its mRNA were found in placentae of as early as 7 weeks of gestation, and they continued to increase throughout pregnancy. But they showed different patterns of increase. The amount of PLAP mRNA began to increase dramatically around 13th week and probably continued to increase gradually until term. PLAP activity per gram of villi showed a gradual increase from around 13th week and a marked increase was observed after about 20th week. PLAP levels in sera from pregnant women were also measured, and they showed a pattern of increase imilar to that of PLAP activity per gram of villi. The continuous increase in the expression of PLAP thoughout pregnancy suggests that PLAP may play a role in feto-maternal metabolism and placental differentiation. |
| doi_str_mv | 10.1016/S0143-4004(05)80223-1 |
| format | Article |
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Both PLAP and its mRNA were found in placentae of as early as 7 weeks of gestation, and they continued to increase throughout pregnancy. But they showed different patterns of increase. The amount of PLAP mRNA began to increase dramatically around 13th week and probably continued to increase gradually until term. PLAP activity per gram of villi showed a gradual increase from around 13th week and a marked increase was observed after about 20th week. PLAP levels in sera from pregnant women were also measured, and they showed a pattern of increase imilar to that of PLAP activity per gram of villi. 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Both PLAP and its mRNA were found in placentae of as early as 7 weeks of gestation, and they continued to increase throughout pregnancy. But they showed different patterns of increase. The amount of PLAP mRNA began to increase dramatically around 13th week and probably continued to increase gradually until term. PLAP activity per gram of villi showed a gradual increase from around 13th week and a marked increase was observed after about 20th week. PLAP levels in sera from pregnant women were also measured, and they showed a pattern of increase imilar to that of PLAP activity per gram of villi. The continuous increase in the expression of PLAP thoughout pregnancy suggests that PLAP may play a role in feto-maternal metabolism and placental differentiation.</description><subject>Alkaline Phosphatase - biosynthesis</subject><subject>Alkaline Phosphatase - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>General aspects. Development. Fetal membranes</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Placenta - enzymology</subject><subject>Pregnancy - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - isolation & purification</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qFWxpfwJSLq3aQ-iMPzbZE0IIWiQEh7Zna-JMWJesE-ykgn9fw64oN04-zPO-43mEOEQ4QsDlt5-AWpUaQH8B87UGKVWJb8QCjZKlQpBvxeIZ2RfvU_oDACuNck_sZdisUC_E1dn9GDklP4Ri6Ir1vKFQjD05DhMV1N9S7wMX43pI45omSlz4F0A7Rx9uilxxEyi4hw_iXUd94o-790D8Pj_7dfqjvLz-fnF6clk6reVUouKuQ5JGYtPQqmort3TIXdsaJMC6YwlEpgblSHNdNUrVXCGrHG8qI9WB-LztHeNwN3Oa7MYnx31PgYc52RoQ1FLpDJot6OKQUuTOjtFvKD5YBPvo0T55tI-SLBj75NFizh3uFszNhtvn1E5cnn_azSk56ruYr_fpf_nKqMos68wdbznONv56jjY5z8Fx6yO7ybaDf-Un_wDtiY-W</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Okamoto, Tomomitsu</creator><creator>Seo, Hisao</creator><creator>Mano, Hisao</creator><creator>Furuhashi, Madoka</creator><creator>Goto, Setsuko</creator><creator>Tomoda, Yutaka</creator><creator>Matsui, Nobuo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Expression of human placenta alkaline phosphatase in placenta during pregnancy</title><author>Okamoto, Tomomitsu ; Seo, Hisao ; Mano, Hisao ; Furuhashi, Madoka ; Goto, Setsuko ; Tomoda, Yutaka ; Matsui, Nobuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-13eff1a2521bba97d7c6c1efdd51a018fe20aa5803ca4e87b338e71e3c44b7523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alkaline Phosphatase - biosynthesis</topic><topic>Alkaline Phosphatase - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Embryology: invertebrates and vertebrates. 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| subjects | Alkaline Phosphatase - biosynthesis Alkaline Phosphatase - isolation & purification Biological and medical sciences Blotting, Northern Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic General aspects. Development. Fetal membranes Gestational Age Humans Placenta - enzymology Pregnancy - metabolism RNA, Messenger - biosynthesis RNA, Messenger - isolation & purification |
| title | Expression of human placenta alkaline phosphatase in placenta during pregnancy |
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