Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population
A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using...
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| Veröffentlicht in: | Neuroscience letters 2004-01, Vol.355 (1), p.149-151 |
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| creator | Liu, Lin-Lin Wei, Jun Zhang, Xuan Li, Xiu-Yi Shen, Yan Liu, Shu-Zheng Ju, Gui-Zhi Shi, Jie-Ping Yu, Ya-Qin Xu, Qi Hemmings, Gwynneth P |
| description | A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding. |
| doi_str_mv | 10.1016/j.neulet.2003.10.059 |
| format | Article |
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To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2003.10.059</identifier><identifier>PMID: 14729256</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult and adolescent clinical studies ; Biological and medical sciences ; China ; Chromosome 6p ; Chromosome Mapping ; DNA Mutational Analysis ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic Heterogeneity ; Genetic Linkage - genetics ; Genetic Testing ; Haplotypes ; Human major histocompatibility complex ; Humans ; Linkage Disequilibrium - genetics ; Male ; Medical sciences ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reproducibility of Results ; Schizophrenia ; Schizophrenia - genetics ; Single nucleotide polymorphisms ; Tenascin - genetics ; Tenascin X (TNXA) ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-01, Vol.355 (1), p.149-151</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-e97240e11070c35d0a7a1853b7a544d3a61d79e5d472111243f2f99bbdf791d13</citedby><cites>FETCH-LOGICAL-c388t-e97240e11070c35d0a7a1853b7a544d3a61d79e5d472111243f2f99bbdf791d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439400301262X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15381595$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14729256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Lin-Lin</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Zhang, Xuan</creatorcontrib><creatorcontrib>Li, Xiu-Yi</creatorcontrib><creatorcontrib>Shen, Yan</creatorcontrib><creatorcontrib>Liu, Shu-Zheng</creatorcontrib><creatorcontrib>Ju, Gui-Zhi</creatorcontrib><creatorcontrib>Shi, Jie-Ping</creatorcontrib><creatorcontrib>Yu, Ya-Qin</creatorcontrib><creatorcontrib>Xu, Qi</creatorcontrib><creatorcontrib>Hemmings, Gwynneth P</creatorcontrib><title>Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Chromosome 6p</subject><subject>Chromosome Mapping</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Linkage - genetics</subject><subject>Genetic Testing</subject><subject>Haplotypes</subject><subject>Human major histocompatibility complex</subject><subject>Humans</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reproducibility of Results</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Single nucleotide polymorphisms</subject><subject>Tenascin - genetics</subject><subject>Tenascin X (TNXA)</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2rEzEUhoMo3nr1H4hko7upJ5OkmWwEb_ELim6u4MqQSc7Y1GkyJjOK_npTW7g7VwcOz_vy8hDylMGaAdu8PKwjLiPO6xaA19capL5HVqxTbaO0au-TFXAQDdcCrsijUg4AIJkUD8kVE6rVrdysyNeddd9pGqil3zDiHBy1pSQX7BxSpD3OvxAjnfdIbz9-uaFjckuhNnpa3D78SdM-YwyWhlgbtvsQsSCd0rSM_woekweDHQs-udxr8vntm9vt-2b36d2H7etd43jXzQ3WvQKQMVDguPRglWWd5L2yUgjP7YZ5pVH6upsx1go-tIPWfe8HpZln_Jq8OPdOOf1YsMzmGIrDcbQR01JMBwy4VJsKijPociol42CmHI42_zYMzMmrOZizV3PyevpWrzX27NK_9Ef0d6GLyAo8vwC2ODsO2UYXyh0neceklpV7deaw2vgZMJviAkaHPmR0s_Ep_H_JX-fal2E</recordid><startdate>20040123</startdate><enddate>20040123</enddate><creator>Liu, Lin-Lin</creator><creator>Wei, Jun</creator><creator>Zhang, Xuan</creator><creator>Li, Xiu-Yi</creator><creator>Shen, Yan</creator><creator>Liu, Shu-Zheng</creator><creator>Ju, Gui-Zhi</creator><creator>Shi, Jie-Ping</creator><creator>Yu, Ya-Qin</creator><creator>Xu, Qi</creator><creator>Hemmings, Gwynneth P</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040123</creationdate><title>Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population</title><author>Liu, Lin-Lin ; Wei, Jun ; Zhang, Xuan ; Li, Xiu-Yi ; Shen, Yan ; Liu, Shu-Zheng ; Ju, Gui-Zhi ; Shi, Jie-Ping ; Yu, Ya-Qin ; Xu, Qi ; Hemmings, Gwynneth P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-e97240e11070c35d0a7a1853b7a544d3a61d79e5d472111243f2f99bbdf791d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Chromosome 6p</topic><topic>Chromosome Mapping</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetic Heterogeneity</topic><topic>Genetic Linkage - genetics</topic><topic>Genetic Testing</topic><topic>Haplotypes</topic><topic>Human major histocompatibility complex</topic><topic>Humans</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reproducibility of Results</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Single nucleotide polymorphisms</topic><topic>Tenascin - genetics</topic><topic>Tenascin X (TNXA)</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lin-Lin</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Zhang, Xuan</creatorcontrib><creatorcontrib>Li, Xiu-Yi</creatorcontrib><creatorcontrib>Shen, Yan</creatorcontrib><creatorcontrib>Liu, Shu-Zheng</creatorcontrib><creatorcontrib>Ju, Gui-Zhi</creatorcontrib><creatorcontrib>Shi, Jie-Ping</creatorcontrib><creatorcontrib>Yu, Ya-Qin</creatorcontrib><creatorcontrib>Xu, Qi</creatorcontrib><creatorcontrib>Hemmings, Gwynneth P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lin-Lin</au><au>Wei, Jun</au><au>Zhang, Xuan</au><au>Li, Xiu-Yi</au><au>Shen, Yan</au><au>Liu, Shu-Zheng</au><au>Ju, Gui-Zhi</au><au>Shi, Jie-Ping</au><au>Yu, Ya-Qin</au><au>Xu, Qi</au><au>Hemmings, Gwynneth P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2004-01-23</date><risdate>2004</risdate><volume>355</volume><issue>1</issue><spage>149</spage><epage>151</epage><pages>149-151</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14729256</pmid><doi>10.1016/j.neulet.2003.10.059</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2004-01, Vol.355 (1), p.149-151 |
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| subjects | Adult and adolescent clinical studies Biological and medical sciences China Chromosome 6p Chromosome Mapping DNA Mutational Analysis Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Heterogeneity Genetic Linkage - genetics Genetic Testing Haplotypes Human major histocompatibility complex Humans Linkage Disequilibrium - genetics Male Medical sciences Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reproducibility of Results Schizophrenia Schizophrenia - genetics Single nucleotide polymorphisms Tenascin - genetics Tenascin X (TNXA) Vertebrates: nervous system and sense organs |
| title | Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population |
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