Thrombosis of aortic valve homograft associated with lupus anticoagulant antibodies
One of the main advantages of an aortic valve homograft in comparison with a mechanical prosthesis is the low incidence of thromboembolism without anticoagulation. Development of an obstructive thrombosis is virtually unknown. We report the case of a patient who twice was seen with hemodynamically s...
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| Veröffentlicht in: | The Annals of thoracic surgery 2004, Vol.77 (1), p.312-314 |
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| creator | Unger, Philippe Plein, Danièle Pradier, Olivier LeClerc, Jean-Louis |
| description | One of the main advantages of an aortic valve homograft in comparison with a mechanical prosthesis is the low incidence of thromboembolism without anticoagulation. Development of an obstructive thrombosis is virtually unknown. We report the case of a patient who twice was seen with hemodynamically significant thrombosis of an aortic valve homograft. The diagnosis was suspected on the basis of a subacute increase in the transvalvular gradient and was confirmed by transesophageal echocardiography. Lupus anticoagulant antibodies were detected. Oral anticoagulation proved to be effective in relieving the obstruction, but recurrence after discontinuation of acenocoumeral suggests that treatment should be long term, if not lifelong. To our knowledge, this complication of primary antiphospholipid syndrome is the first reported case of thrombotic obstruction of an aortic valve homograft. |
| doi_str_mv | 10.1016/S0003-4975(03)01039-7 |
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Development of an obstructive thrombosis is virtually unknown. We report the case of a patient who twice was seen with hemodynamically significant thrombosis of an aortic valve homograft. The diagnosis was suspected on the basis of a subacute increase in the transvalvular gradient and was confirmed by transesophageal echocardiography. Lupus anticoagulant antibodies were detected. Oral anticoagulation proved to be effective in relieving the obstruction, but recurrence after discontinuation of acenocoumeral suggests that treatment should be long term, if not lifelong. 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Vascular system ; Dermatology ; Diseases of the aorta ; Female ; Homograft ; Humans ; Lupus anticoagulant antibodies ; Lupus Coagulation Inhibitor - immunology ; Medical sciences ; Pneumology ; Postoperative Complications - blood ; Postoperative Complications - etiology ; Skin involvement in other diseases. Miscellaneous. 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Development of an obstructive thrombosis is virtually unknown. We report the case of a patient who twice was seen with hemodynamically significant thrombosis of an aortic valve homograft. The diagnosis was suspected on the basis of a subacute increase in the transvalvular gradient and was confirmed by transesophageal echocardiography. Lupus anticoagulant antibodies were detected. Oral anticoagulation proved to be effective in relieving the obstruction, but recurrence after discontinuation of acenocoumeral suggests that treatment should be long term, if not lifelong. To our knowledge, this complication of primary antiphospholipid syndrome is the first reported case of thrombotic obstruction of an aortic valve homograft.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibodies - blood</subject><subject>Antiphospholipid Syndrome - complications</subject><subject>Aortic Valve - transplantation</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Dermatology</subject><subject>Diseases of the aorta</subject><subject>Female</subject><subject>Homograft</subject><subject>Humans</subject><subject>Lupus anticoagulant antibodies</subject><subject>Lupus Coagulation Inhibitor - immunology</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - etiology</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Thrombosis</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - etiology</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPHDEMgKOqqCy0P6HVXFrBYSCZZF4nVCFe0koclp4jT-KwqWY223hmEf-e7EPlyMGyrXx2rI-x74JfCC6qywXnXOaqrcszLs-54LLN609sJsqyyKuibD-z2X_kmJ0Q_U1tkZ6_sGOh6qLiTTVji6dlDEMXyFMWXAYhjt5kG-g3mC3DEJ4juDEDomA8jGizFz8us35aT5TBKrEBnqc-VbuuC9YjfWVHDnrCb4d8yv7c3jxd3-fzx7uH69_z3Khajjm0neiEELxQiBILgMrWqrKts7LhDdqagwDuUDXbsMZUqrRWOYOuLUDJU_Zrv3cdw78JadSDJ4N9OgfDRLrZWlFtk8ByD5oYiCI6vY5-gPiqBddbm3pnU29V6ZR3NnWd5n4cPpi6Ae371EFfAn4eACADvYuwMp7euVJJJSueuKs9h0nHxmPUZDyuDFof0YzaBv_BKW_M55M-</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Unger, Philippe</creator><creator>Plein, Danièle</creator><creator>Pradier, Olivier</creator><creator>LeClerc, Jean-Louis</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Thrombosis of aortic valve homograft associated with lupus anticoagulant antibodies</title><author>Unger, Philippe ; Plein, Danièle ; Pradier, Olivier ; LeClerc, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-a9b1b111024ee3e2aa6d746d9fd3808ed70a1a0fe48fe48dcc645dd4fcef92a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Anesthesia. 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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies - blood Antiphospholipid Syndrome - complications Aortic Valve - transplantation Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Dermatology Diseases of the aorta Female Homograft Humans Lupus anticoagulant antibodies Lupus Coagulation Inhibitor - immunology Medical sciences Pneumology Postoperative Complications - blood Postoperative Complications - etiology Skin involvement in other diseases. Miscellaneous. General aspects Thrombosis Thrombosis - blood Thrombosis - etiology |
| title | Thrombosis of aortic valve homograft associated with lupus anticoagulant antibodies |
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