Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma

Characterization of the molecular basis of tumor recognition by T cells has shown that major histocompatibility complex (MHC) class I molecules play a crucial role in presenting antigenic peptide epitopes to cytotoxic T lymphocytes. MHC class Ia downregulation has been repeatedly described on melano...

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Veröffentlicht in:	Cancer letters 2004, Vol.203 (2), p.225-231
Hauptverfasser:	Dissemond, Joachim, Busch, Michael, Kothen, Thomas, Mörs, Janet, Weimann, Tatjana K, Lindeke, Anette, Goos, Manfred, Wagner, Stephan N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation Binding sites Calnexin Calnexin - biosynthesis Calnexin - genetics Calreticulin Calreticulin - biosynthesis Calreticulin - genetics Disease Progression Down-Regulation Endoplasmic reticulum Endoplasmic Reticulum - metabolism Gene Expression Regulation, Neoplastic Histocompatibility complex class I Humans Immune system Immunohistochemistry Immunotherapy - methods Melanoma Melanoma - metabolism Melanoma - pathology Neoplasm Metastasis Peptides Phenotype Skin Neoplasms - metabolism T-Lymphocytes - metabolism
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