Structure-activity relationship of synthetic truncated analogues of vasoactive intestinal peptide (VIP): an enhancement in the activity by a substitution with arginine

In order to develop potent shortened analogues of vasoactive intestinal peptide (VIP), the structure-activity relationship of C-terminally truncated analogues of VIP was investigated by examining the binding activity to rat lung VIP receptors and relaxation of smooth muscle in isolated mouse stomach...

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Veröffentlicht in:	Life sciences (1973) 2004-02, Vol.74 (12), p.1465-1477
Hauptverfasser:	Onoue, Satomi, Ohmori, Yuki, Matsumoto, Asami, Yamada, Shizuo, Kimura, Ryohei, Yajima, Takehiko, Kashimoto, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arginine - metabolism C-terminally truncated analogues Gastric Mucosa - metabolism In Vitro Techniques Lung - metabolism Male Mice Molecular Sequence Data Peptide Fragments - genetics Peptide Fragments - metabolism Rats Rats, Sprague-Dawley Receptor binding Relaxant activity Sequence Alignment Stomach - anatomy & histology Structure-Activity Relationship Vasoactive Intestinal Peptide - chemistry Vasoactive Intestinal Peptide - metabolism VIP VPAC 2 receptor
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