Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man
A 42-year-old Korean man with a fibrolamellar carcinoma of the liver is described. His initial symptom was an epigastric mass without pain, which resulted in a left lobectomy of the liver. A whitish and hard tumor, 10 cm in maximum diameter, without any cirrhotic features was noted in the resected l...
Gespeichert in:
| Veröffentlicht in: | Journal of UOEH 1990/09/01, Vol.12(3), pp.349-354 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 354 |
|---|---|
| container_issue | 3 |
| container_start_page | 349 |
| container_title | Journal of UOEH |
| container_volume | 12 |
| creator | HARATAKE, Joji HORIE, Akio LEE, Sung Do HUH, Man-Ha |
| description | A 42-year-old Korean man with a fibrolamellar carcinoma of the liver is described. His initial symptom was an epigastric mass without pain, which resulted in a left lobectomy of the liver. A whitish and hard tumor, 10 cm in maximum diameter, without any cirrhotic features was noted in the resected liver. Histologically, the tumor was composed of lamellarly distributed fibrous stroma and polyhedral large cancer cells, which showed eosinophilic granular cytoplasm and rounded nuclei. Prominent nucleoli, scattered pale bodies and numerous copper-binding protein deposits were seen in the cancer cells. Orcein-stain failed to show HBsAg-laden cells in both the cancerous and non-cancerous tissues, and alpha-fetoprotein was not seen in the cancer cells by an immuno-peroxidase staining. Fibrolamellar carcinoma has been found almost exclusively in Caucasians and is very rare in Orientals. We describe this rare case with a review of the literature. |
| doi_str_mv | 10.7888/juoeh.12.349 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80102537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80102537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3059-cca5cb0963f7186a13e87a435cdf19240b0c038f20fbc035b0063e9ab76a58f93</originalsourceid><addsrcrecordid>eNpNkM1LAzEQxYMotX7cvAo5eXLrJNnsZm9KsVrb4kXBW5jNZu2W_ajJVvC_N7WlOIeZgffjMfMIuWIwSpVSd6tNZ5cjxkcizo7IkDOVRlwl8TEZggi74uzjlJx5vwKQKmZyQAacpQIyPiT3kyp3XY2NrWt0dIzOVG3XIO1K2i8tnVff1tGqpUgXVVHUNsJPW9BZ5yy2dIHtBTkpsfb2cj_Pyfvk8W38HM1fn6bjh3lkBMgsMgalySFLRJkylSATVqUYC2mKkmU8hhxMuLbkUOZhkTlAImyGeZqgVGUmzsnNznftuq-N9b1uKm-2V7e223itgAGXIg3g7Q40rvPe2VKvXdWg-9EM9DYw_ReYZlyHwAJ-vffd5I0tDvA-oaBPd_rK9-H1g46ur0xt_5lt2-wFQnEJUrD0wJglOm1b8QuRwH74</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80102537</pqid></control><display><type>article</type><title>Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>HARATAKE, Joji ; HORIE, Akio ; LEE, Sung Do ; HUH, Man-Ha</creator><creatorcontrib>HARATAKE, Joji ; HORIE, Akio ; LEE, Sung Do ; HUH, Man-Ha</creatorcontrib><description>A 42-year-old Korean man with a fibrolamellar carcinoma of the liver is described. His initial symptom was an epigastric mass without pain, which resulted in a left lobectomy of the liver. A whitish and hard tumor, 10 cm in maximum diameter, without any cirrhotic features was noted in the resected liver. Histologically, the tumor was composed of lamellarly distributed fibrous stroma and polyhedral large cancer cells, which showed eosinophilic granular cytoplasm and rounded nuclei. Prominent nucleoli, scattered pale bodies and numerous copper-binding protein deposits were seen in the cancer cells. Orcein-stain failed to show HBsAg-laden cells in both the cancerous and non-cancerous tissues, and alpha-fetoprotein was not seen in the cancer cells by an immuno-peroxidase staining. Fibrolamellar carcinoma has been found almost exclusively in Caucasians and is very rare in Orientals. We describe this rare case with a review of the literature.</description><identifier>ISSN: 0387-821X</identifier><identifier>EISSN: 2187-2864</identifier><identifier>DOI: 10.7888/juoeh.12.349</identifier><identifier>PMID: 2173092</identifier><language>eng</language><publisher>Japan: The University of Occupational and Environmental Health, Japan</publisher><subject>Adult ; Asian Continental Ancestry Group ; Carcinoma, Hepatocellular - ethnology ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Carrier Proteins - metabolism ; Cell Nucleus - pathology ; Cytoplasmic Granules - pathology ; fibrolamellar type ; Fibrosis ; Hepatectomy ; hepatocellular carcinoma ; Humans ; Korea ; Korean ; Liver Neoplasms - ethnology ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male</subject><ispartof>Journal of UOEH, 1990/09/01, Vol.12(3), pp.349-354</ispartof><rights>1990 The University of Occupational and Environmental Health, Japan</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3059-cca5cb0963f7186a13e87a435cdf19240b0c038f20fbc035b0063e9ab76a58f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2173092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARATAKE, Joji</creatorcontrib><creatorcontrib>HORIE, Akio</creatorcontrib><creatorcontrib>LEE, Sung Do</creatorcontrib><creatorcontrib>HUH, Man-Ha</creatorcontrib><title>Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man</title><title>Journal of UOEH</title><addtitle>J UOEH</addtitle><description>A 42-year-old Korean man with a fibrolamellar carcinoma of the liver is described. His initial symptom was an epigastric mass without pain, which resulted in a left lobectomy of the liver. A whitish and hard tumor, 10 cm in maximum diameter, without any cirrhotic features was noted in the resected liver. Histologically, the tumor was composed of lamellarly distributed fibrous stroma and polyhedral large cancer cells, which showed eosinophilic granular cytoplasm and rounded nuclei. Prominent nucleoli, scattered pale bodies and numerous copper-binding protein deposits were seen in the cancer cells. Orcein-stain failed to show HBsAg-laden cells in both the cancerous and non-cancerous tissues, and alpha-fetoprotein was not seen in the cancer cells by an immuno-peroxidase staining. Fibrolamellar carcinoma has been found almost exclusively in Caucasians and is very rare in Orientals. We describe this rare case with a review of the literature.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group</subject><subject>Carcinoma, Hepatocellular - ethnology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Cytoplasmic Granules - pathology</subject><subject>fibrolamellar type</subject><subject>Fibrosis</subject><subject>Hepatectomy</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Korea</subject><subject>Korean</subject><subject>Liver Neoplasms - ethnology</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><issn>0387-821X</issn><issn>2187-2864</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LAzEQxYMotX7cvAo5eXLrJNnsZm9KsVrb4kXBW5jNZu2W_ajJVvC_N7WlOIeZgffjMfMIuWIwSpVSd6tNZ5cjxkcizo7IkDOVRlwl8TEZggi74uzjlJx5vwKQKmZyQAacpQIyPiT3kyp3XY2NrWt0dIzOVG3XIO1K2i8tnVff1tGqpUgXVVHUNsJPW9BZ5yy2dIHtBTkpsfb2cj_Pyfvk8W38HM1fn6bjh3lkBMgsMgalySFLRJkylSATVqUYC2mKkmU8hhxMuLbkUOZhkTlAImyGeZqgVGUmzsnNznftuq-N9b1uKm-2V7e223itgAGXIg3g7Q40rvPe2VKvXdWg-9EM9DYw_ReYZlyHwAJ-vffd5I0tDvA-oaBPd_rK9-H1g46ur0xt_5lt2-wFQnEJUrD0wJglOm1b8QuRwH74</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>HARATAKE, Joji</creator><creator>HORIE, Akio</creator><creator>LEE, Sung Do</creator><creator>HUH, Man-Ha</creator><general>The University of Occupational and Environmental Health, Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man</title><author>HARATAKE, Joji ; HORIE, Akio ; LEE, Sung Do ; HUH, Man-Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3059-cca5cb0963f7186a13e87a435cdf19240b0c038f20fbc035b0063e9ab76a58f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group</topic><topic>Carcinoma, Hepatocellular - ethnology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Nucleus - pathology</topic><topic>Cytoplasmic Granules - pathology</topic><topic>fibrolamellar type</topic><topic>Fibrosis</topic><topic>Hepatectomy</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Korea</topic><topic>Korean</topic><topic>Liver Neoplasms - ethnology</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><toplevel>online_resources</toplevel><creatorcontrib>HARATAKE, Joji</creatorcontrib><creatorcontrib>HORIE, Akio</creatorcontrib><creatorcontrib>LEE, Sung Do</creatorcontrib><creatorcontrib>HUH, Man-Ha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of UOEH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARATAKE, Joji</au><au>HORIE, Akio</au><au>LEE, Sung Do</au><au>HUH, Man-Ha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man</atitle><jtitle>Journal of UOEH</jtitle><addtitle>J UOEH</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>12</volume><issue>3</issue><spage>349</spage><epage>354</epage><pages>349-354</pages><issn>0387-821X</issn><eissn>2187-2864</eissn><abstract>A 42-year-old Korean man with a fibrolamellar carcinoma of the liver is described. His initial symptom was an epigastric mass without pain, which resulted in a left lobectomy of the liver. A whitish and hard tumor, 10 cm in maximum diameter, without any cirrhotic features was noted in the resected liver. Histologically, the tumor was composed of lamellarly distributed fibrous stroma and polyhedral large cancer cells, which showed eosinophilic granular cytoplasm and rounded nuclei. Prominent nucleoli, scattered pale bodies and numerous copper-binding protein deposits were seen in the cancer cells. Orcein-stain failed to show HBsAg-laden cells in both the cancerous and non-cancerous tissues, and alpha-fetoprotein was not seen in the cancer cells by an immuno-peroxidase staining. Fibrolamellar carcinoma has been found almost exclusively in Caucasians and is very rare in Orientals. We describe this rare case with a review of the literature.</abstract><cop>Japan</cop><pub>The University of Occupational and Environmental Health, Japan</pub><pmid>2173092</pmid><doi>10.7888/juoeh.12.349</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0387-821X |
| ispartof | Journal of UOEH, 1990/09/01, Vol.12(3), pp.349-354 |
| issn | 0387-821X 2187-2864 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80102537 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adult Asian Continental Ancestry Group Carcinoma, Hepatocellular - ethnology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Carrier Proteins - metabolism Cell Nucleus - pathology Cytoplasmic Granules - pathology fibrolamellar type Fibrosis Hepatectomy hepatocellular carcinoma Humans Korea Korean Liver Neoplasms - ethnology Liver Neoplasms - pathology Liver Neoplasms - surgery Male |
| title | Fibrolamellar Carcinoma of the Liver in a Middle-aged Korean Man |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A14%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fibrolamellar%20Carcinoma%20of%20the%20Liver%20in%20a%20Middle-aged%20Korean%20Man&rft.jtitle=Journal%20of%20UOEH&rft.au=HARATAKE,%20Joji&rft.date=1990-09-01&rft.volume=12&rft.issue=3&rft.spage=349&rft.epage=354&rft.pages=349-354&rft.issn=0387-821X&rft.eissn=2187-2864&rft_id=info:doi/10.7888/juoeh.12.349&rft_dat=%3Cproquest_cross%3E80102537%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80102537&rft_id=info:pmid/2173092&rfr_iscdi=true |