Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study
Among the putative mechanisms, by which extremely low frequency (ELF) magnetic field (MF) may affect biological systems is that of increasing free radical life span in organisms. To test this hypothesis, we investigated whether ELF (60 Hz) MF can modulate antioxidant system in mouse brain by detecti...
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| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 2004-01, Vol.73 (1), p.43-48 |
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| creator | Lee, Byung-Cheon Johng, Hyeon-Min Lim, Jae-Kwan Jeong, Ji Hoon Baik, Ku Youn Nam, Tae Jeong Lee, Jung Ho Kim, Jungdae Sohn, Uy Dong Yoon, Gilwon Shin, Sanghoon Soh, Kwang-Sup |
| description | Among the putative mechanisms, by which extremely low frequency (ELF) magnetic field (MF) may affect biological systems is that of increasing free radical life span in organisms. To test this hypothesis, we investigated whether ELF (60 Hz) MF can modulate antioxidant system in mouse brain by detecting chemiluminescence and measuring superoxide dismutase (SOD) activity in homogenates of the organ. Compared to sham exposed control group, lucigenin-initiated chemiluminescence in exposed group was not significantly increased. However, lucigenin-amplified
t-butyl hydroperoxide (TBHP)-initiated brain homogenates chemiluminescence, was significantly increased in mouse exposed to 60 Hz, MF, 12 G for 3 h compared to sham exposed group. We also measured SOD activity, that plays a critical role of the antioxidant defensive system in brain. In the group exposed to 60 Hz, MF, 12 G for 3 h, brain SOD activity was significantly increased. These results suggest that 60 Hz, MF could deteriorate antioxidant defensive system by reactive oxygen species (ROS), other than superoxide radicals. Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress. |
| doi_str_mv | 10.1016/j.jphotobiol.2003.10.003 |
| format | Article |
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t-butyl hydroperoxide (TBHP)-initiated brain homogenates chemiluminescence, was significantly increased in mouse exposed to 60 Hz, MF, 12 G for 3 h compared to sham exposed group. We also measured SOD activity, that plays a critical role of the antioxidant defensive system in brain. In the group exposed to 60 Hz, MF, 12 G for 3 h, brain SOD activity was significantly increased. These results suggest that 60 Hz, MF could deteriorate antioxidant defensive system by reactive oxygen species (ROS), other than superoxide radicals. Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2003.10.003</identifier><identifier>PMID: 14732250</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Animals ; Antioxidants - pharmacology ; Brain - enzymology ; Brain - metabolism ; Chemiluminescence ; Extremely low frequency magnetic field ; Lucigenin ; Luminescent Measurements ; Magnetics ; Mice ; Mice, Inbred BALB C ; Reactive oxygen species ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; t-Butyl hydroperoxide ; tert-Butylhydroperoxide - pharmacology</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 2004-01, Vol.73 (1), p.43-48</ispartof><rights>2003 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-64f587621b0d4250ddd8783a5b2336aafee40b312657a3c5aa9bc5eedd8dea023</citedby><cites>FETCH-LOGICAL-c467t-64f587621b0d4250ddd8783a5b2336aafee40b312657a3c5aa9bc5eedd8dea023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1011134403001519$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14732250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Byung-Cheon</creatorcontrib><creatorcontrib>Johng, Hyeon-Min</creatorcontrib><creatorcontrib>Lim, Jae-Kwan</creatorcontrib><creatorcontrib>Jeong, Ji Hoon</creatorcontrib><creatorcontrib>Baik, Ku Youn</creatorcontrib><creatorcontrib>Nam, Tae Jeong</creatorcontrib><creatorcontrib>Lee, Jung Ho</creatorcontrib><creatorcontrib>Kim, Jungdae</creatorcontrib><creatorcontrib>Sohn, Uy Dong</creatorcontrib><creatorcontrib>Yoon, Gilwon</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Soh, Kwang-Sup</creatorcontrib><title>Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>Among the putative mechanisms, by which extremely low frequency (ELF) magnetic field (MF) may affect biological systems is that of increasing free radical life span in organisms. To test this hypothesis, we investigated whether ELF (60 Hz) MF can modulate antioxidant system in mouse brain by detecting chemiluminescence and measuring superoxide dismutase (SOD) activity in homogenates of the organ. Compared to sham exposed control group, lucigenin-initiated chemiluminescence in exposed group was not significantly increased. However, lucigenin-amplified
t-butyl hydroperoxide (TBHP)-initiated brain homogenates chemiluminescence, was significantly increased in mouse exposed to 60 Hz, MF, 12 G for 3 h compared to sham exposed group. We also measured SOD activity, that plays a critical role of the antioxidant defensive system in brain. In the group exposed to 60 Hz, MF, 12 G for 3 h, brain SOD activity was significantly increased. These results suggest that 60 Hz, MF could deteriorate antioxidant defensive system by reactive oxygen species (ROS), other than superoxide radicals. Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Brain - enzymology</subject><subject>Brain - metabolism</subject><subject>Chemiluminescence</subject><subject>Extremely low frequency magnetic field</subject><subject>Lucigenin</subject><subject>Luminescent Measurements</subject><subject>Magnetics</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Reactive oxygen species</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>t-Butyl hydroperoxide</subject><subject>tert-Butylhydroperoxide - pharmacology</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu3CAUhq2oVe6vULHqzhMutnG6a6P0IkXqpl0jDIcOIwNTwG286Lv3jGakLMPm5_KdC-dvGsLohlE23O02u_021TT5NG84pQKvNyhnzSUbpWj5MPI3uKeMtUx03UVzVcqO4uoHed5csE4Kznt62fx7dA5MLSQ5As81Q4B5JXP6S1yG3wtEs5Kgf0Wo3hDnYbYkRVK3QHSsPj17i0osOIgFSFlLhUB8JCEteJ6y9vED0cRsIfh5CT5CMZgU0brY9aZ56_Rc4Pak183Pz48_Hr62T9-_fHv4-NSabpC1HTrXj3LgbKK2w7attaMche4nLsSgtQPo6CQYH3qphem1vp9MD4CYBU25uG7eH_Puc8JPlaqCxz7mWUfARtVIGeXdOL4KMnkveykZguMRNDmVksGpffZB51Uxqg4eqZ168UgdPDq8oGDou1ONZQpgXwJPpiDw6QgAjuSPh6yK8YehWZ_RK2WTf73Kfz3Vqvg</recordid><startdate>20040123</startdate><enddate>20040123</enddate><creator>Lee, Byung-Cheon</creator><creator>Johng, Hyeon-Min</creator><creator>Lim, Jae-Kwan</creator><creator>Jeong, Ji Hoon</creator><creator>Baik, Ku Youn</creator><creator>Nam, Tae Jeong</creator><creator>Lee, Jung Ho</creator><creator>Kim, Jungdae</creator><creator>Sohn, Uy Dong</creator><creator>Yoon, Gilwon</creator><creator>Shin, Sanghoon</creator><creator>Soh, Kwang-Sup</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20040123</creationdate><title>Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study</title><author>Lee, Byung-Cheon ; Johng, Hyeon-Min ; Lim, Jae-Kwan ; Jeong, Ji Hoon ; Baik, Ku Youn ; Nam, Tae Jeong ; Lee, Jung Ho ; Kim, Jungdae ; Sohn, Uy Dong ; Yoon, Gilwon ; Shin, Sanghoon ; Soh, Kwang-Sup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-64f587621b0d4250ddd8783a5b2336aafee40b312657a3c5aa9bc5eedd8dea023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Brain - enzymology</topic><topic>Brain - metabolism</topic><topic>Chemiluminescence</topic><topic>Extremely low frequency magnetic field</topic><topic>Lucigenin</topic><topic>Luminescent Measurements</topic><topic>Magnetics</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Reactive oxygen species</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>t-Butyl hydroperoxide</topic><topic>tert-Butylhydroperoxide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Byung-Cheon</creatorcontrib><creatorcontrib>Johng, Hyeon-Min</creatorcontrib><creatorcontrib>Lim, Jae-Kwan</creatorcontrib><creatorcontrib>Jeong, Ji Hoon</creatorcontrib><creatorcontrib>Baik, Ku Youn</creatorcontrib><creatorcontrib>Nam, Tae Jeong</creatorcontrib><creatorcontrib>Lee, Jung Ho</creatorcontrib><creatorcontrib>Kim, Jungdae</creatorcontrib><creatorcontrib>Sohn, Uy Dong</creatorcontrib><creatorcontrib>Yoon, Gilwon</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Soh, Kwang-Sup</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of photochemistry and photobiology. 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B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2004-01-23</date><risdate>2004</risdate><volume>73</volume><issue>1</issue><spage>43</spage><epage>48</epage><pages>43-48</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><abstract>Among the putative mechanisms, by which extremely low frequency (ELF) magnetic field (MF) may affect biological systems is that of increasing free radical life span in organisms. To test this hypothesis, we investigated whether ELF (60 Hz) MF can modulate antioxidant system in mouse brain by detecting chemiluminescence and measuring superoxide dismutase (SOD) activity in homogenates of the organ. Compared to sham exposed control group, lucigenin-initiated chemiluminescence in exposed group was not significantly increased. However, lucigenin-amplified
t-butyl hydroperoxide (TBHP)-initiated brain homogenates chemiluminescence, was significantly increased in mouse exposed to 60 Hz, MF, 12 G for 3 h compared to sham exposed group. We also measured SOD activity, that plays a critical role of the antioxidant defensive system in brain. In the group exposed to 60 Hz, MF, 12 G for 3 h, brain SOD activity was significantly increased. These results suggest that 60 Hz, MF could deteriorate antioxidant defensive system by reactive oxygen species (ROS), other than superoxide radicals. Further studies are needed to identify the kind of ROS generated by the exposure to 60 Hz, MF and elucidate how MF can affect biological system in connection with oxidative stress.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>14732250</pmid><doi>10.1016/j.jphotobiol.2003.10.003</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antioxidants - pharmacology Brain - enzymology Brain - metabolism Chemiluminescence Extremely low frequency magnetic field Lucigenin Luminescent Measurements Magnetics Mice Mice, Inbred BALB C Reactive oxygen species Superoxide dismutase Superoxide Dismutase - metabolism t-Butyl hydroperoxide tert-Butylhydroperoxide - pharmacology |
| title | Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study |
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