Unifying the Epidemiological and Evolutionary Dynamics of Pathogens

A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-01, Vol.303 (5656), p.327-332
Hauptverfasser:	Grenfell, Bryan T., Pybus, Oliver G., Gog, Julia R., James L. N. Wood, Daly, Janet M., Mumford, Jenny A., Holmes, Edward C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Antigenic Variation - genetics Biological and medical sciences Biological Evolution Communicable Diseases Disease Outbreaks - veterinary Disease transmission Epidemics Epidemiology Epidemiology. Vaccinations Evolution General aspects Genetic mutation Genetics Genetics, Population HIV Humans Immunity Immunology Infections Infectious diseases Inferences Measles Medical sciences Mutation Pathogens Phylogeny Population Dynamics Review RNA Virus Infections - epidemiology RNA Virus Infections - immunology RNA Virus Infections - veterinary RNA Virus Infections - virology RNA Viruses - genetics RNA Viruses - immunology RNA Viruses - pathogenicity RNA Viruses - physiology Selection, Genetic Time Factors Vaccination Viruses
Online-Zugang:	Volltext
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