Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis

Mitochondria are known to combine life-supporting functions with participation in apoptosis by controlling caspase activity. Here, we report that in human blood neutrophils the mitochondria are different, because they preserve mainly death-mediating abilities. Neutrophil mitochondria hardly particip...

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Veröffentlicht in:	Cell death and differentiation 2004-02, Vol.11 (2), p.143-153
Hauptverfasser:	Maianski, N A, Geissler, J, Srinivasula, S M, Alnemri, E S, Roos, D, Kuijpers, T W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Apoptosis bcl-2-Associated X Protein Caspase 9 Caspases - metabolism Cell death Cell Differentiation Cell Lineage Cytochrome Cytochromes c - metabolism Cytosol - metabolism Dehydrogenases DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Fumarate Hydratase - metabolism Glutamate Dehydrogenase - metabolism HL-60 Cells Humans L-Lactate Dehydrogenase - metabolism Membrane Potentials Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - metabolism Neutrophils Neutrophils - cytology Neutrophils - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Respiration Tumor necrosis factor-TNF
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