Vinburnine decelerates [3H]N-methylscopolamine binding to recombinant human muscarinic M1-M4 acetylcholine receptors

The kinetics of [3H]N-methylscopolamine binding to membranes of Chinese hamster ovary (CHO) cells expressing muscarinic M(1)-M(4) acetylcholine receptors was studied. [3H]N-methylscopolamine dissociation was used for the "single-point" analysis of allosteric modulation by vinburnine (L-ebu...

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Veröffentlicht in:	European journal of pharmacology 2004-01, Vol.483 (2-3), p.229-232
Hauptverfasser:	MAKSAY, Gabor, BIRO, Timea, KISS, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Allosteric Regulation - physiology Animals Biological and medical sciences CHO Cells Cricetinae Humans Medical sciences N-Methylscopolamine - antagonists & inhibitors N-Methylscopolamine - metabolism Pharmacology. Drug treatments Protein Binding - drug effects Protein Binding - physiology Receptor, Muscarinic M1 - metabolism Receptor, Muscarinic M2 - metabolism Receptor, Muscarinic M3 - metabolism Receptor, Muscarinic M4 - metabolism Receptors, Muscarinic - metabolism Recombinant Proteins - metabolism Tritium - metabolism Vinca Alkaloids - pharmacology
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