Indecent Exposure: When Telomeres Become Uncapped

Indecent Exposure: When Telomeres Become Uncapped

The protective “cap” that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the...

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Veröffentlicht in:Molecular Cell 2004-01, Vol.13 (1), p.7-18
Hauptverfasser: Ferreira, Miguel Godinho, Miller, Kyle M, Cooper, Julia Promisel
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromosome Aberrations
DNA Damage
Humans
Models, Molecular
Saccharomyces cerevisiae Proteins - metabolism
Schizosaccharomyces pombe Proteins - metabolism
Telomerase - metabolism
Telomere - metabolism
Telomere - physiology
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Zusammenfassung:The protective “cap” that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(03)00531-8