Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients
1 Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2 Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy Correspondence L. Dolzani Dolzani{at}dsbmail.units.it Received September 13, 2003 Accepted October 24, 2003 Fifty-o...
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| Veröffentlicht in: | Journal of medical microbiology 2004-02, Vol.53 (2), p.155-159 |
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| creator | Dolzani, L Rosato, M Sartori, B Banfi, E Lagatolla, C Predominato, M Fabris, C Tonin, E Gombac, F Monti-Bragadin, C |
| description | 1 Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2 Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy
Correspondence L. Dolzani Dolzani{at}dsbmail.units.it
Received September 13, 2003
Accepted October 24, 2003
Fifty-one consecutive isolates of Mycobacterium tuberculosis , collected during a 2-year period in the north-east of Italy, were subjected to IS 6110 -RFLP analysis to detect the presence of clusters and assigned to one of the three genotypic groups delineated by single nucleotide polymorphisms in the genes katG and gyrA . All the isolates collected from the local population belonged to group 2 or 3, while group 1 isolates were found only in specimens collected from African immigrants. Clustered cases of tuberculosis, which are likely to be related to recently transmitted infection, were found to be significantly associated with katG gyrA group 2. In the local situation, strains belonging to this group may therefore present a higher risk of transmission. |
| doi_str_mv | 10.1099/jmm.0.05471-0 |
| format | Article |
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Correspondence L. Dolzani Dolzani{at}dsbmail.units.it
Received September 13, 2003
Accepted October 24, 2003
Fifty-one consecutive isolates of Mycobacterium tuberculosis , collected during a 2-year period in the north-east of Italy, were subjected to IS 6110 -RFLP analysis to detect the presence of clusters and assigned to one of the three genotypic groups delineated by single nucleotide polymorphisms in the genes katG and gyrA . All the isolates collected from the local population belonged to group 2 or 3, while group 1 isolates were found only in specimens collected from African immigrants. Clustered cases of tuberculosis, which are likely to be related to recently transmitted infection, were found to be significantly associated with katG gyrA group 2. In the local situation, strains belonging to this group may therefore present a higher risk of transmission.</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/jmm.0.05471-0</identifier><identifier>PMID: 14729938</identifier><identifier>CODEN: JMMIAV</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents - pharmacology ; Bacterial diseases ; Bacterial Proteins ; Biological and medical sciences ; Catalase ; Cluster Analysis ; DNA Gyrase - genetics ; DNA Transposable Elements ; Drug Resistance, Bacterial ; Fundamental and applied biological sciences. Psychology ; Genotype ; Human bacterial diseases ; Humans ; Infectious diseases ; Italy - epidemiology ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Middle Aged ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - classification ; Mycobacterium tuberculosis - genetics ; Oxidoreductases - genetics ; Polymorphism, Restriction Fragment Length ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis and atypical mycobacterial infections</subject><ispartof>Journal of medical microbiology, 2004-02, Vol.53 (2), p.155-159</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-da88b5a15f3f0ca95034980344ae04bb6893bdf33d31a95e8ed2c38d71fa85293</citedby><cites>FETCH-LOGICAL-c423t-da88b5a15f3f0ca95034980344ae04bb6893bdf33d31a95e8ed2c38d71fa85293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3733,3734,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15434231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14729938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dolzani, L</creatorcontrib><creatorcontrib>Rosato, M</creatorcontrib><creatorcontrib>Sartori, B</creatorcontrib><creatorcontrib>Banfi, E</creatorcontrib><creatorcontrib>Lagatolla, C</creatorcontrib><creatorcontrib>Predominato, M</creatorcontrib><creatorcontrib>Fabris, C</creatorcontrib><creatorcontrib>Tonin, E</creatorcontrib><creatorcontrib>Gombac, F</creatorcontrib><creatorcontrib>Monti-Bragadin, C</creatorcontrib><title>Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>1 Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2 Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy
Correspondence L. Dolzani Dolzani{at}dsbmail.units.it
Received September 13, 2003
Accepted October 24, 2003
Fifty-one consecutive isolates of Mycobacterium tuberculosis , collected during a 2-year period in the north-east of Italy, were subjected to IS 6110 -RFLP analysis to detect the presence of clusters and assigned to one of the three genotypic groups delineated by single nucleotide polymorphisms in the genes katG and gyrA . All the isolates collected from the local population belonged to group 2 or 3, while group 1 isolates were found only in specimens collected from African immigrants. Clustered cases of tuberculosis, which are likely to be related to recently transmitted infection, were found to be significantly associated with katG gyrA group 2. In the local situation, strains belonging to this group may therefore present a higher risk of transmission.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Bacterial Proteins</subject><subject>Biological and medical sciences</subject><subject>Catalase</subject><subject>Cluster Analysis</subject><subject>DNA Gyrase - genetics</subject><subject>DNA Transposable Elements</subject><subject>Drug Resistance, Bacterial</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Italy - epidemiology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - classification</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Oxidoreductases - genetics</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFvFCEYBmBibOxaPXo1XNTTrDAMO3BsmlqbtOmlnskHw8xSZ4aVj0mzf8FfLetu0sSLFwjhycsXXkI-cLbmTOuvT9O0Zmsmm5ZX7BVZ8aYVldw0zWuyYqyuq3rD5Tl5i_jEGG-F0G_IeUG11kKtyO_7vYsWXPYpLBPNi_XJLWPEgDRgHCF7pNaPcR7CPNAc6U_IN3TYp0s6pLjsaE0heQqI0YWiO_oc8pa6ccGSWY4OsETE_p_smd5mGAPMdAc5-DnjO3LWw4j-_Wm_ID--XT9efa_uHm5ury7vKtfUIlcdKGUlcNmLnjnQkolGq7I04Flj7UZpYbteiE7wcuuV72onVNfyHpSstbggn4-5uxR_LR6zmQI6P44w-7igUYwz1mr-X8jb8lSrNgVWR-hSREy-N7sUJkh7w5k5tGRKS4aZvy0ZVvzHU_BiJ9-96FMtBXw6AUAHY59gdgFfnGxE-YvDhF-ObhuG7XNI3gx-nkIZw4Z4eFQKUxcuxR-TtKtB</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Dolzani, L</creator><creator>Rosato, M</creator><creator>Sartori, B</creator><creator>Banfi, E</creator><creator>Lagatolla, C</creator><creator>Predominato, M</creator><creator>Fabris, C</creator><creator>Tonin, E</creator><creator>Gombac, F</creator><creator>Monti-Bragadin, C</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients</title><author>Dolzani, L ; Rosato, M ; Sartori, B ; Banfi, E ; Lagatolla, C ; Predominato, M ; Fabris, C ; Tonin, E ; Gombac, F ; Monti-Bragadin, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-da88b5a15f3f0ca95034980344ae04bb6893bdf33d31a95e8ed2c38d71fa85293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Bacterial Proteins</topic><topic>Biological and medical sciences</topic><topic>Catalase</topic><topic>Cluster Analysis</topic><topic>DNA Gyrase - genetics</topic><topic>DNA Transposable Elements</topic><topic>Drug Resistance, Bacterial</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Italy - epidemiology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - classification</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Oxidoreductases - genetics</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dolzani, L</creatorcontrib><creatorcontrib>Rosato, M</creatorcontrib><creatorcontrib>Sartori, B</creatorcontrib><creatorcontrib>Banfi, E</creatorcontrib><creatorcontrib>Lagatolla, C</creatorcontrib><creatorcontrib>Predominato, M</creatorcontrib><creatorcontrib>Fabris, C</creatorcontrib><creatorcontrib>Tonin, E</creatorcontrib><creatorcontrib>Gombac, F</creatorcontrib><creatorcontrib>Monti-Bragadin, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dolzani, L</au><au>Rosato, M</au><au>Sartori, B</au><au>Banfi, E</au><au>Lagatolla, C</au><au>Predominato, M</au><au>Fabris, C</au><au>Tonin, E</au><au>Gombac, F</au><au>Monti-Bragadin, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>53</volume><issue>2</issue><spage>155</spage><epage>159</epage><pages>155-159</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract>1 Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2 Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy
Correspondence L. Dolzani Dolzani{at}dsbmail.units.it
Received September 13, 2003
Accepted October 24, 2003
Fifty-one consecutive isolates of Mycobacterium tuberculosis , collected during a 2-year period in the north-east of Italy, were subjected to IS 6110 -RFLP analysis to detect the presence of clusters and assigned to one of the three genotypic groups delineated by single nucleotide polymorphisms in the genes katG and gyrA . All the isolates collected from the local population belonged to group 2 or 3, while group 1 isolates were found only in specimens collected from African immigrants. Clustered cases of tuberculosis, which are likely to be related to recently transmitted infection, were found to be significantly associated with katG gyrA group 2. In the local situation, strains belonging to this group may therefore present a higher risk of transmission.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>14729938</pmid><doi>10.1099/jmm.0.05471-0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antitubercular Agents - pharmacology Bacterial diseases Bacterial Proteins Biological and medical sciences Catalase Cluster Analysis DNA Gyrase - genetics DNA Transposable Elements Drug Resistance, Bacterial Fundamental and applied biological sciences. Psychology Genotype Human bacterial diseases Humans Infectious diseases Italy - epidemiology Medical sciences Microbial Sensitivity Tests Microbiology Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - classification Mycobacterium tuberculosis - genetics Oxidoreductases - genetics Polymorphism, Restriction Fragment Length Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis and atypical mycobacterial infections |
| title | Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients |
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