Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP

The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in many glioma cell lines. However, treatment with TRAIL in combination with subtoxic doses of roscovitine, a specific inhibitor of Cdc2 and Cdk2, induced rapid apoptosis in TRAIL-resistant glioma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2004-01, Vol.23 (2), p.446-456
Hauptverfasser:	Kim, Eun Hee, Kim, Seung U, Shin, Deug Y, Choi, Kyeong Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins Astrocytes - drug effects Astrocytes - metabolism bcl-X Protein Biological and medical sciences Brain cancer CDC2 Protein Kinase - antagonists & inhibitors CDC2 Protein Kinase - metabolism Cell Biology Cell Cycle - drug effects Cell death Cell Line, Tumor Cell physiology Cell Survival - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytotoxicity Down-Regulation - drug effects Drug dosages Fundamental and applied biological sciences. Psychology Glioma - metabolism Glioma - pathology Human Genetics Humans Inhibitor of Apoptosis Proteins Internal Medicine Kinases Ligands Medical prognosis Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins - metabolism Microtubule-Associated Proteins - metabolism Molecular and cellular biology Neoplasm Proteins Neurology Oncology original-paper Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Purines - pharmacology TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumors of the nervous system. Phacomatoses X-Linked Inhibitor of Apoptosis Protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!