Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo
Acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) may be difficult to distinguish by clinical or histologic assessment. Reflectance confocal microscopy (RCM) enables real-time, high-resolution skin imaging in vivo. We sought to image, characterize, and distinguish acute A...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2004-02, Vol.50 (2), p.220-228 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Swindells, Kirsty Burnett, Nadine Rius-Diaz, Francisca González, Ernesto Mihm, Martin C González, Salvador |
| description | Acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) may be difficult to distinguish by clinical or histologic assessment. Reflectance confocal microscopy (RCM) enables real-time, high-resolution skin imaging in vivo.
We sought to image, characterize, and distinguish acute ACD and ICD in vivo.
Volunteers with ACD were patch tested with an allergen and the irritant, sodium lauryl sulfate. RCM imaging and transepidermal water loss measurements were performed at 24 and 72 hours. Biopsy specimens were correlated with RCM images.
Spongiosis, epidermal inflammatory cell infiltrate, and vesicle formation were observed in ACD and ICD. Compared with ACD, ICD showed greater disruption of the stratum corneum, and more parakeratosis. There was a significantly greater increase in transepidermal water loss for ICD compared with ACD.
RCM is a promising tool for dynamic, noninvasive assessment and may help to differentiate acute ACD and sodium lauryl sulfate–induced ICD. |
| doi_str_mv | 10.1016/j.jaad.2003.08.005 |
| format | Article |
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We sought to image, characterize, and distinguish acute ACD and ICD in vivo.
Volunteers with ACD were patch tested with an allergen and the irritant, sodium lauryl sulfate. RCM imaging and transepidermal water loss measurements were performed at 24 and 72 hours. Biopsy specimens were correlated with RCM images.
Spongiosis, epidermal inflammatory cell infiltrate, and vesicle formation were observed in ACD and ICD. Compared with ACD, ICD showed greater disruption of the stratum corneum, and more parakeratosis. There was a significantly greater increase in transepidermal water loss for ICD compared with ACD.
RCM is a promising tool for dynamic, noninvasive assessment and may help to differentiate acute ACD and sodium lauryl sulfate–induced ICD.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2003.08.005</identifier><identifier>PMID: 14726876</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biopsy ; Dermatitis, Allergic Contact - diagnosis ; Dermatitis, Allergic Contact - pathology ; Dermatitis, Irritant - diagnosis ; Dermatitis, Irritant - pathology ; Dermatology ; Diagnosis, Differential ; Female ; Humans ; Male ; Medical sciences ; Microscopy, Confocal - methods ; Middle Aged ; Sensitivity and Specificity ; Skin Tests</subject><ispartof>Journal of the American Academy of Dermatology, 2004-02, Vol.50 (2), p.220-228</ispartof><rights>2004 American Academy of Dermatology, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-a2fdc4580ae4902e3d4c82524f85621df353eac3422b70310c1b0aa299cdfc33</citedby><cites>FETCH-LOGICAL-c382t-a2fdc4580ae4902e3d4c82524f85621df353eac3422b70310c1b0aa299cdfc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2003.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15582983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14726876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swindells, Kirsty</creatorcontrib><creatorcontrib>Burnett, Nadine</creatorcontrib><creatorcontrib>Rius-Diaz, Francisca</creatorcontrib><creatorcontrib>González, Ernesto</creatorcontrib><creatorcontrib>Mihm, Martin C</creatorcontrib><creatorcontrib>González, Salvador</creatorcontrib><title>Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) may be difficult to distinguish by clinical or histologic assessment. Reflectance confocal microscopy (RCM) enables real-time, high-resolution skin imaging in vivo.
We sought to image, characterize, and distinguish acute ACD and ICD in vivo.
Volunteers with ACD were patch tested with an allergen and the irritant, sodium lauryl sulfate. RCM imaging and transepidermal water loss measurements were performed at 24 and 72 hours. Biopsy specimens were correlated with RCM images.
Spongiosis, epidermal inflammatory cell infiltrate, and vesicle formation were observed in ACD and ICD. Compared with ACD, ICD showed greater disruption of the stratum corneum, and more parakeratosis. There was a significantly greater increase in transepidermal water loss for ICD compared with ACD.
RCM is a promising tool for dynamic, noninvasive assessment and may help to differentiate acute ACD and sodium lauryl sulfate–induced ICD.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dermatitis, Allergic Contact - diagnosis</subject><subject>Dermatitis, Allergic Contact - pathology</subject><subject>Dermatitis, Irritant - diagnosis</subject><subject>Dermatitis, Irritant - pathology</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Confocal - methods</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Skin Tests</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rHDEMhk1oaDZp_0APxZf2NhPZng8P9FJC2xQChZK70dpy6mU-trZ3Yf99PexCbr1Il0cv0iPGPgioBYjuflfvEF0tAVQNugZor9hGwNBXXa_7N2wDYoBq6KS8Ybcp7QBgaFT_lt2Ipped7rsN-_Ob_Eg242yJ22X2i8WRT8HGJdllf-ITnrgL3lOkOQfMxNEe1jqOFF-C5Tg7HmIMJSKvCRlt5o7ihDnkkHiY-TEcl3fs2uOY6P2l37Hn79-eHx6rp18_fj58faqs0jJXKL2zTasBqRlAknKN1bKVjddtJ4XzqlWEVjVSbntQAqzYAqIcBuu8VeqOfT7H7uPy90ApmykkS-OIMy2HZHRxMIBuCijP4HppiuTNPoYJ48kIMKteszOrXrPqNaBN0VuGPl7SD9uJ3OvIxWcBPl0ATEWkj8VrSK9c22o56HXNL2eOiopjoGiSDVR-4EIs3zBuCf_b4x8yFppV</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Swindells, Kirsty</creator><creator>Burnett, Nadine</creator><creator>Rius-Diaz, Francisca</creator><creator>González, Ernesto</creator><creator>Mihm, Martin C</creator><creator>González, Salvador</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo</title><author>Swindells, Kirsty ; Burnett, Nadine ; Rius-Diaz, Francisca ; González, Ernesto ; Mihm, Martin C ; González, Salvador</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-a2fdc4580ae4902e3d4c82524f85621df353eac3422b70310c1b0aa299cdfc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dermatitis, Allergic Contact - diagnosis</topic><topic>Dermatitis, Allergic Contact - pathology</topic><topic>Dermatitis, Irritant - diagnosis</topic><topic>Dermatitis, Irritant - pathology</topic><topic>Dermatology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Confocal - methods</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swindells, Kirsty</creatorcontrib><creatorcontrib>Burnett, Nadine</creatorcontrib><creatorcontrib>Rius-Diaz, Francisca</creatorcontrib><creatorcontrib>González, Ernesto</creatorcontrib><creatorcontrib>Mihm, Martin C</creatorcontrib><creatorcontrib>González, Salvador</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swindells, Kirsty</au><au>Burnett, Nadine</au><au>Rius-Diaz, Francisca</au><au>González, Ernesto</au><au>Mihm, Martin C</au><au>González, Salvador</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>50</volume><issue>2</issue><spage>220</spage><epage>228</epage><pages>220-228</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) may be difficult to distinguish by clinical or histologic assessment. Reflectance confocal microscopy (RCM) enables real-time, high-resolution skin imaging in vivo.
We sought to image, characterize, and distinguish acute ACD and ICD in vivo.
Volunteers with ACD were patch tested with an allergen and the irritant, sodium lauryl sulfate. RCM imaging and transepidermal water loss measurements were performed at 24 and 72 hours. Biopsy specimens were correlated with RCM images.
Spongiosis, epidermal inflammatory cell infiltrate, and vesicle formation were observed in ACD and ICD. Compared with ACD, ICD showed greater disruption of the stratum corneum, and more parakeratosis. There was a significantly greater increase in transepidermal water loss for ICD compared with ACD.
RCM is a promising tool for dynamic, noninvasive assessment and may help to differentiate acute ACD and sodium lauryl sulfate–induced ICD.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>14726876</pmid><doi>10.1016/j.jaad.2003.08.005</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Biological and medical sciences Biopsy Dermatitis, Allergic Contact - diagnosis Dermatitis, Allergic Contact - pathology Dermatitis, Irritant - diagnosis Dermatitis, Irritant - pathology Dermatology Diagnosis, Differential Female Humans Male Medical sciences Microscopy, Confocal - methods Middle Aged Sensitivity and Specificity Skin Tests |
| title | Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo |
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