Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

A series of 9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(alkyltetrazol-5-yl)- 6,8-nonadienoic acid derivatives 1 were synthesized and found to inhibit competitively the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The analogues having 1N-methyltetrazol-5-yl attached to the C8-positi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1990-11, Vol.33 (11), p.2982-2999
Hauptverfasser:	Sit, S. Y, Parker, R. A, Motoc, I, Han, W, Balasubramanian, N, Catt, J. D, Brown, P. J, Harte, W. E, Thompson, M. D, Wright, J. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - pharmacology Binding, Competitive Butadienes - chemical synthesis Butadienes - chemistry Butadienes - pharmacology Chemical Phenomena Chemistry Cholesterol - biosynthesis Fatty Acids, Unsaturated - chemical synthesis Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors Liver - metabolism Male Microsomes, Liver - enzymology Models, Molecular Molecular Structure Pyrones - chemical synthesis Pyrones - chemistry Pyrones - pharmacology Rats Rats, Inbred Strains Structure-Activity Relationship Tetrazoles - chemical synthesis Tetrazoles - chemistry Tetrazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!