Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy
Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity...
Gespeichert in:
| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1990-11, Vol.39 (11), p.1204-1210 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1210 |
|---|---|
| container_issue | 11 |
| container_start_page | 1204 |
| container_title | Metabolism, clinical and experimental |
| container_volume | 39 |
| creator | Nyomba, Bulangu L. Freymond, Daniel Raz, Itamar Stone, Karen Mott, David M. Bogardus, Clifton |
| description | Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity determined in skeletal muscle biopsies taken during euglycemic hyperinsulinemic clamps in nine Pima Indians with NIDDM. Insulin was infused at the rate of 40 mU/m
2/min (low dose) followed by 400 mU/m
2/min (high dose). Compared with the fasting value, the mean glycogen synthase activity assayed at low glucose-6-phosphate (G6P) concentration (active glycogen synthase) showed no significant changes during insulin infusion before glyburide treatment. After glyburide treatment, the mean active glycogen synthase increased by 39% (
P < .05) above the fasting value during the high-dose insulin infusion. Total glycogen synthase activity assayed at high G6P concentration did not change after glyburide treatment. Changes of insulin-stimulated active glycogen synthase associated with glyburide treatment correlated with changes in total body glucose disposal rates (
r = .70,
P < .05) during euglycemic clamps. We conclude that glyburide treatment of subjects with NIDDM is associated with an increase in insulin action in vivo and concomitantly with improved insulin action on skeletal muscle glycogen synthase. |
| doi_str_mv | 10.1016/0026-0495(90)90096-U |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80098690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>002604959090096U</els_id><sourcerecordid>80098690</sourcerecordid><originalsourceid>FETCH-LOGICAL-c302t-73a734e8f4948c93b43547c533f4cb930731cfa16bf94156503dd883244c4cdc3</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EKtvCPwDJF1A5BMaxk9iXSqjiS6rEAfZsOfak6-I4i-0URfx5suyq3DiNNPO8r0YPIS8YvGXA2ncAdVuBUM2lgjcKQLXV9hHZsIbXlWwBHpPNA_KUnOd8BwBdJ9szclazumZdtyG_v_3AgMUEOs7ZBqS3YbHTLUaal1h2JiM1tvh7Xxbq1-Xc36Etmf7yZUfjFCsf8xx8rBzuMTqMhTpveiyY6Ygh-DJnaoaC6dDcz8k7pGWHyeyXZ-TJYELG56d5QbYfP3y__lzdfP305fr9TWU51KXquOm4QDkIJaRVvBe8EZ1tOB-E7RWHjjM7GNb2gxKsaRvgzknJayGssM7yC_L62LtP088Zc9Gjz3Z9zkSc5qzl6k62ClZQHEGbppwTDnqf_GjSohnog3N9EKoPQrUC_de53q6xl6f-uR_RPYROktf7q9PdZGvCkEy0Pv_rVrKRUsiVuzpyuMq495h0th6jRefTKl27yf__kT9fcqAK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80098690</pqid></control><display><type>article</type><title>Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Nyomba, Bulangu L. ; Freymond, Daniel ; Raz, Itamar ; Stone, Karen ; Mott, David M. ; Bogardus, Clifton</creator><creatorcontrib>Nyomba, Bulangu L. ; Freymond, Daniel ; Raz, Itamar ; Stone, Karen ; Mott, David M. ; Bogardus, Clifton</creatorcontrib><description>Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity determined in skeletal muscle biopsies taken during euglycemic hyperinsulinemic clamps in nine Pima Indians with NIDDM. Insulin was infused at the rate of 40 mU/m
2/min (low dose) followed by 400 mU/m
2/min (high dose). Compared with the fasting value, the mean glycogen synthase activity assayed at low glucose-6-phosphate (G6P) concentration (active glycogen synthase) showed no significant changes during insulin infusion before glyburide treatment. After glyburide treatment, the mean active glycogen synthase increased by 39% (
P < .05) above the fasting value during the high-dose insulin infusion. Total glycogen synthase activity assayed at high G6P concentration did not change after glyburide treatment. Changes of insulin-stimulated active glycogen synthase associated with glyburide treatment correlated with changes in total body glucose disposal rates (
r = .70,
P < .05) during euglycemic clamps. We conclude that glyburide treatment of subjects with NIDDM is associated with an increase in insulin action in vivo and concomitantly with improved insulin action on skeletal muscle glycogen synthase.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(90)90096-U</identifier><identifier>PMID: 2122177</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - enzymology ; Dose-Response Relationship, Drug ; Epinephrine - blood ; Fasting ; Female ; Glucose-6-Phosphate ; Glucosephosphates - metabolism ; Glyburide - therapeutic use ; Glycogen Synthase - metabolism ; Hormones. Endocrine system ; Humans ; Insulin - metabolism ; Insulin - therapeutic use ; Insulin Secretion ; Male ; Medical sciences ; Muscles - enzymology ; Pharmacology. Drug treatments</subject><ispartof>Metabolism, clinical and experimental, 1990-11, Vol.39 (11), p.1204-1210</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-73a734e8f4948c93b43547c533f4cb930731cfa16bf94156503dd883244c4cdc3</citedby><cites>FETCH-LOGICAL-c302t-73a734e8f4948c93b43547c533f4cb930731cfa16bf94156503dd883244c4cdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(90)90096-U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27913,27914,45984</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19858848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2122177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyomba, Bulangu L.</creatorcontrib><creatorcontrib>Freymond, Daniel</creatorcontrib><creatorcontrib>Raz, Itamar</creatorcontrib><creatorcontrib>Stone, Karen</creatorcontrib><creatorcontrib>Mott, David M.</creatorcontrib><creatorcontrib>Bogardus, Clifton</creatorcontrib><title>Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity determined in skeletal muscle biopsies taken during euglycemic hyperinsulinemic clamps in nine Pima Indians with NIDDM. Insulin was infused at the rate of 40 mU/m
2/min (low dose) followed by 400 mU/m
2/min (high dose). Compared with the fasting value, the mean glycogen synthase activity assayed at low glucose-6-phosphate (G6P) concentration (active glycogen synthase) showed no significant changes during insulin infusion before glyburide treatment. After glyburide treatment, the mean active glycogen synthase increased by 39% (
P < .05) above the fasting value during the high-dose insulin infusion. Total glycogen synthase activity assayed at high G6P concentration did not change after glyburide treatment. Changes of insulin-stimulated active glycogen synthase associated with glyburide treatment correlated with changes in total body glucose disposal rates (
r = .70,
P < .05) during euglycemic clamps. We conclude that glyburide treatment of subjects with NIDDM is associated with an increase in insulin action in vivo and concomitantly with improved insulin action on skeletal muscle glycogen synthase.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - enzymology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epinephrine - blood</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose-6-Phosphate</subject><subject>Glucosephosphates - metabolism</subject><subject>Glyburide - therapeutic use</subject><subject>Glycogen Synthase - metabolism</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Secretion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - enzymology</subject><subject>Pharmacology. Drug treatments</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKtvCPwDJF1A5BMaxk9iXSqjiS6rEAfZsOfak6-I4i-0URfx5suyq3DiNNPO8r0YPIS8YvGXA2ncAdVuBUM2lgjcKQLXV9hHZsIbXlWwBHpPNA_KUnOd8BwBdJ9szclazumZdtyG_v_3AgMUEOs7ZBqS3YbHTLUaal1h2JiM1tvh7Xxbq1-Xc36Etmf7yZUfjFCsf8xx8rBzuMTqMhTpveiyY6Ygh-DJnaoaC6dDcz8k7pGWHyeyXZ-TJYELG56d5QbYfP3y__lzdfP305fr9TWU51KXquOm4QDkIJaRVvBe8EZ1tOB-E7RWHjjM7GNb2gxKsaRvgzknJayGssM7yC_L62LtP088Zc9Gjz3Z9zkSc5qzl6k62ClZQHEGbppwTDnqf_GjSohnog3N9EKoPQrUC_de53q6xl6f-uR_RPYROktf7q9PdZGvCkEy0Pv_rVrKRUsiVuzpyuMq495h0th6jRefTKl27yf__kT9fcqAK</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>Nyomba, Bulangu L.</creator><creator>Freymond, Daniel</creator><creator>Raz, Itamar</creator><creator>Stone, Karen</creator><creator>Mott, David M.</creator><creator>Bogardus, Clifton</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199011</creationdate><title>Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy</title><author>Nyomba, Bulangu L. ; Freymond, Daniel ; Raz, Itamar ; Stone, Karen ; Mott, David M. ; Bogardus, Clifton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-73a734e8f4948c93b43547c533f4cb930731cfa16bf94156503dd883244c4cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epinephrine - blood</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose-6-Phosphate</topic><topic>Glucosephosphates - metabolism</topic><topic>Glyburide - therapeutic use</topic><topic>Glycogen Synthase - metabolism</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Secretion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - enzymology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyomba, Bulangu L.</creatorcontrib><creatorcontrib>Freymond, Daniel</creatorcontrib><creatorcontrib>Raz, Itamar</creatorcontrib><creatorcontrib>Stone, Karen</creatorcontrib><creatorcontrib>Mott, David M.</creatorcontrib><creatorcontrib>Bogardus, Clifton</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyomba, Bulangu L.</au><au>Freymond, Daniel</au><au>Raz, Itamar</au><au>Stone, Karen</au><au>Mott, David M.</au><au>Bogardus, Clifton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1990-11</date><risdate>1990</risdate><volume>39</volume><issue>11</issue><spage>1204</spage><epage>1210</epage><pages>1204-1210</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity determined in skeletal muscle biopsies taken during euglycemic hyperinsulinemic clamps in nine Pima Indians with NIDDM. Insulin was infused at the rate of 40 mU/m
2/min (low dose) followed by 400 mU/m
2/min (high dose). Compared with the fasting value, the mean glycogen synthase activity assayed at low glucose-6-phosphate (G6P) concentration (active glycogen synthase) showed no significant changes during insulin infusion before glyburide treatment. After glyburide treatment, the mean active glycogen synthase increased by 39% (
P < .05) above the fasting value during the high-dose insulin infusion. Total glycogen synthase activity assayed at high G6P concentration did not change after glyburide treatment. Changes of insulin-stimulated active glycogen synthase associated with glyburide treatment correlated with changes in total body glucose disposal rates (
r = .70,
P < .05) during euglycemic clamps. We conclude that glyburide treatment of subjects with NIDDM is associated with an increase in insulin action in vivo and concomitantly with improved insulin action on skeletal muscle glycogen synthase.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2122177</pmid><doi>10.1016/0026-0495(90)90096-U</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-0495 |
| ispartof | Metabolism, clinical and experimental, 1990-11, Vol.39 (11), p.1204-1210 |
| issn | 0026-0495 1532-8600 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80098690 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Dose-Response Relationship, Drug Epinephrine - blood Fasting Female Glucose-6-Phosphate Glucosephosphates - metabolism Glyburide - therapeutic use Glycogen Synthase - metabolism Hormones. Endocrine system Humans Insulin - metabolism Insulin - therapeutic use Insulin Secretion Male Medical sciences Muscles - enzymology Pharmacology. Drug treatments |
| title | Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A06%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Skeletal%20muscle%20glycogen%20synthase%20activity%20in%20subjects%20with%20non-insulin-dependent%20diabetes%20mellitus%20after%20glyburide%20therapy&rft.jtitle=Metabolism,%20clinical%20and%20experimental&rft.au=Nyomba,%20Bulangu%20L.&rft.date=1990-11&rft.volume=39&rft.issue=11&rft.spage=1204&rft.epage=1210&rft.pages=1204-1210&rft.issn=0026-0495&rft.eissn=1532-8600&rft_id=info:doi/10.1016/0026-0495(90)90096-U&rft_dat=%3Cproquest_cross%3E80098690%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80098690&rft_id=info:pmid/2122177&rft_els_id=002604959090096U&rfr_iscdi=true |