Estrogen receptor β inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest

Studies indicate that estrogen receptor (ER) alpha mediates breast cancer-promoting effects of estrogens. The role of ERbeta in breast cancer is unknown. Elucidating the role of ERbeta in the pathogenesis of breast cancer is important because many human breast tumors express both ERalpha and ERbeta....

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004, Vol.64 (1), p.423-428
Hauptverfasser:	PARUTHIYIL, Sreenivasan, PARMAR, Hema, KEREKATTE, Vaishali, CUNHA, Gerald R, FIRESTONE, Gary L, LEITMAN, Dale C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - pathology Breast Neoplasms - prevention & control Cell Cycle - drug effects Cell Division - drug effects DNA Primers Estradiol - pharmacology Estrogen Receptor beta Female G2 Phase - drug effects Humans Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Receptors, Estrogen - genetics Reverse Transcriptase Polymerase Chain Reaction Transcription, Genetic Transplantation, Heterologous Tumors
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