The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4
Hox genes encode a family of transcription factors that specify positional identities along the anterior–posterior (AP) axis during the development of vertebrate embryos. The earliest Hox expression in vertebrates is during gastrulation, at a position distant from the organiser or its equivalent. Ho...
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| Veröffentlicht in: | Developmental biology 2004-02, Vol.266 (1), p.123-137 |
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| creator | Wacker, S.A McNulty, C.L Durston, A.J |
| description | Hox genes encode a family of transcription factors that specify positional identities along the anterior–posterior (AP) axis during the development of vertebrate embryos. The earliest
Hox expression in vertebrates is during gastrulation, at a position distant from the organiser or its equivalent. However, the mechanism that initiates this early expression is still not clear. Guided by the expression pattern, we identified upstream regulators in
Xenopus laevis. The mesodermal transcription factor brachyury (
Xbra) controls the early
Hox expression domain in the animal–vegetal direction and the secreted growth factor BMP-4 limits it in the organiser/non-organiser direction. The overlap of these two signals, indicated by a Cartesian coordinate system, defines the initial
Hox expression domain. We postulate that this system is a general mechanism for the activation of all
Hox genes expressed during gastrulation. |
| doi_str_mv | 10.1016/j.ydbio.2003.10.011 |
| format | Article |
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Hox expression in vertebrates is during gastrulation, at a position distant from the organiser or its equivalent. However, the mechanism that initiates this early expression is still not clear. Guided by the expression pattern, we identified upstream regulators in
Xenopus laevis. The mesodermal transcription factor brachyury (
Xbra) controls the early
Hox expression domain in the animal–vegetal direction and the secreted growth factor BMP-4 limits it in the organiser/non-organiser direction. The overlap of these two signals, indicated by a Cartesian coordinate system, defines the initial
Hox expression domain. We postulate that this system is a general mechanism for the activation of all
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Hox expression in vertebrates is during gastrulation, at a position distant from the organiser or its equivalent. However, the mechanism that initiates this early expression is still not clear. Guided by the expression pattern, we identified upstream regulators in
Xenopus laevis. The mesodermal transcription factor brachyury (
Xbra) controls the early
Hox expression domain in the animal–vegetal direction and the secreted growth factor BMP-4 limits it in the organiser/non-organiser direction. The overlap of these two signals, indicated by a Cartesian coordinate system, defines the initial
Hox expression domain. We postulate that this system is a general mechanism for the activation of all
Hox genes expressed during gastrulation.</description><subject>Animals</subject><subject>BMP-4</subject><subject>Bone Morphogenetic Protein 4</subject><subject>Bone Morphogenetic Proteins - physiology</subject><subject>Brachyury</subject><subject>Brachyury protein</subject><subject>Fetal Proteins - physiology</subject><subject>Freshwater</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genes, Homeobox</subject><subject>Hox</subject><subject>Hox gene</subject><subject>In Situ Hybridization</subject><subject>Non-organiser mesoderm</subject><subject>Organiser mesoderm</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>T-Box Domain Proteins - physiology</subject><subject>Xbra</subject><subject>Xbra gene</subject><subject>Xenopus</subject><subject>Xenopus laevis</subject><subject>Xenopus laevis - genetics</subject><subject>Xenopus Proteins</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGKFDEQhoMo7rj6BILk5K3Hqk66Ozl4cBd1hRU9zGEPQsgk1W6GnmRMupftt7fHGfCmUFDw8_1V8DH2GmGNgO273Xr225DWNYBYkjUgPmErBN1UTSvvnrIVANYVttBesBel7GABlRLP2QXKrtZSiRX7sbknHmIYgx1Dijz1_CY98p8UidPjIVMpxzhEfkcxHabCB0sPofBlXIpjTsNAnm9nfpWtu5-nPHMbPb_6-r2SL9mz3g6FXp33Jdt8-ri5vqluv33-cv3htnKyqcdKaqeEbyR24J1W6LaN9rqvUXjbeSt6oXyPtus99tK2VgnXCGmJWgSrW3HJ3p7OHnL6NVEZzT4UR8NgI6WpGAWgFdTdf0HUdQO1bBZQnECXUymZenPIYW_zbBDMUb7ZmT_yzVH-MVzkL6035_PTdk_-b-dsewHenwBaZDwEyqa4QNGRD5ncaHwK_3zwGwQDlow</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Wacker, S.A</creator><creator>McNulty, C.L</creator><creator>Durston, A.J</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4</title><author>Wacker, S.A ; 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The earliest
Hox expression in vertebrates is during gastrulation, at a position distant from the organiser or its equivalent. However, the mechanism that initiates this early expression is still not clear. Guided by the expression pattern, we identified upstream regulators in
Xenopus laevis. The mesodermal transcription factor brachyury (
Xbra) controls the early
Hox expression domain in the animal–vegetal direction and the secreted growth factor BMP-4 limits it in the organiser/non-organiser direction. The overlap of these two signals, indicated by a Cartesian coordinate system, defines the initial
Hox expression domain. We postulate that this system is a general mechanism for the activation of all
Hox genes expressed during gastrulation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14729483</pmid><doi>10.1016/j.ydbio.2003.10.011</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental biology, 2004-02, Vol.266 (1), p.123-137 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals BMP-4 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - physiology Brachyury Brachyury protein Fetal Proteins - physiology Freshwater Gene Expression Regulation, Developmental - physiology Genes, Homeobox Hox Hox gene In Situ Hybridization Non-organiser mesoderm Organiser mesoderm Polymerase Chain Reaction RNA, Messenger - genetics T-Box Domain Proteins - physiology Xbra Xbra gene Xenopus Xenopus laevis Xenopus laevis - genetics Xenopus Proteins |
| title | The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4 |
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