Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome
Abstract A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed...
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| Veröffentlicht in: | Neuropediatrics 1990-08, Vol.21 (3), p.124-129 |
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| container_title | Neuropediatrics |
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| creator | Belec, L. Tayot, J. Tron, P. Mikol, J. Scaravilli, F. Gray, F. |
| description | Abstract
A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.
ABBREVIATIONS
Acquired immuno-deficiency syndrome: AIDSCytomegalovirus: CMV Human Immuno-Deficiency Virus: HIV Central Nervous System: CNS |
| doi_str_mv | 10.1055/s-2008-1071477 |
| format | Article |
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A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.
ABBREVIATIONS
Acquired immuno-deficiency syndrome: AIDSCytomegalovirus: CMV Human Immuno-Deficiency Virus: HIV Central Nervous System: CNS</description><identifier>ISSN: 0174-304X</identifier><identifier>EISSN: 1439-1899</identifier><identifier>DOI: 10.1055/s-2008-1071477</identifier><identifier>PMID: 2172857</identifier><language>eng</language><publisher>Germany</publisher><subject>AIDS-Related Complex - pathology ; AIDS/HIV ; Brain - pathology ; Cytomegalovirus Infections - congenital ; Cytomegalovirus Infections - pathology ; Encephalitis - congenital ; Encephalitis - pathology ; Female ; HIV Seropositivity - congenital ; Humans ; Inclusion Bodies, Viral - ultrastructure ; Infant ; Infant, Newborn ; Infant, Premature, Diseases - pathology ; Microscopy, Electron ; Opportunistic Infections - congenital ; Opportunistic Infections - pathology ; Original article</subject><ispartof>Neuropediatrics, 1990-08, Vol.21 (3), p.124-129</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2437-e2466f0a82e767cfdb770139918da9abaeb9cbfa993f02d985f78d517e52e81e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2008-1071477.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2172857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belec, L.</creatorcontrib><creatorcontrib>Tayot, J.</creatorcontrib><creatorcontrib>Tron, P.</creatorcontrib><creatorcontrib>Mikol, J.</creatorcontrib><creatorcontrib>Scaravilli, F.</creatorcontrib><creatorcontrib>Gray, F.</creatorcontrib><title>Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome</title><title>Neuropediatrics</title><addtitle>Neuropediatrics</addtitle><description>Abstract
A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.
ABBREVIATIONS
Acquired immuno-deficiency syndrome: AIDSCytomegalovirus: CMV Human Immuno-Deficiency Virus: HIV Central Nervous System: CNS</description><subject>AIDS-Related Complex - pathology</subject><subject>AIDS/HIV</subject><subject>Brain - pathology</subject><subject>Cytomegalovirus Infections - congenital</subject><subject>Cytomegalovirus Infections - pathology</subject><subject>Encephalitis - congenital</subject><subject>Encephalitis - pathology</subject><subject>Female</subject><subject>HIV Seropositivity - congenital</subject><subject>Humans</subject><subject>Inclusion Bodies, Viral - ultrastructure</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature, Diseases - pathology</subject><subject>Microscopy, Electron</subject><subject>Opportunistic Infections - congenital</subject><subject>Opportunistic Infections - pathology</subject><subject>Original article</subject><issn>0174-304X</issn><issn>1439-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMouq5evQk5ecua9CvJUdavBcGDCt5Cmk5sljbdTVql_94uu3jzNAzvOw_Mg9AVowtG8_w2koRSQRjlLOP8CM1YlkrChJTHaEYZz0hKs88zdB7jmlKWSVqcotOE8UTkfIbUcuy7Fr500327MET84A1s6mnd6L4esfNYe7zyVvse_7i-xsvOf4F3vW7wndkOLkCFV207-I7cg3XGgTcjfht9FSbwBTqxuolweZhz9PH48L58Ji-vT6vl3QsxSZZyAklWFJZqkQAvuLFVyTllqZRMVFrqUkMpTWm1lKmlSSVFbrmocsYhT0AwSOfoZs_dhG47QOxV66KBptEeuiEqQankMi-m4mJfNKGLMYBVm-BaHUbFqNoZVVHtjKqD0eng-kAeyhaqv_pB4ZSTfd7XDlpQ624Ifnr1P94v9WWAiA</recordid><startdate>199008</startdate><enddate>199008</enddate><creator>Belec, L.</creator><creator>Tayot, J.</creator><creator>Tron, P.</creator><creator>Mikol, J.</creator><creator>Scaravilli, F.</creator><creator>Gray, F.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199008</creationdate><title>Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome</title><author>Belec, L. ; Tayot, J. ; Tron, P. ; Mikol, J. ; Scaravilli, F. ; Gray, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2437-e2466f0a82e767cfdb770139918da9abaeb9cbfa993f02d985f78d517e52e81e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>AIDS-Related Complex - pathology</topic><topic>AIDS/HIV</topic><topic>Brain - pathology</topic><topic>Cytomegalovirus Infections - congenital</topic><topic>Cytomegalovirus Infections - pathology</topic><topic>Encephalitis - congenital</topic><topic>Encephalitis - pathology</topic><topic>Female</topic><topic>HIV Seropositivity - congenital</topic><topic>Humans</topic><topic>Inclusion Bodies, Viral - ultrastructure</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature, Diseases - pathology</topic><topic>Microscopy, Electron</topic><topic>Opportunistic Infections - congenital</topic><topic>Opportunistic Infections - pathology</topic><topic>Original article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belec, L.</creatorcontrib><creatorcontrib>Tayot, J.</creatorcontrib><creatorcontrib>Tron, P.</creatorcontrib><creatorcontrib>Mikol, J.</creatorcontrib><creatorcontrib>Scaravilli, F.</creatorcontrib><creatorcontrib>Gray, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belec, L.</au><au>Tayot, J.</au><au>Tron, P.</au><au>Mikol, J.</au><au>Scaravilli, F.</au><au>Gray, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome</atitle><jtitle>Neuropediatrics</jtitle><addtitle>Neuropediatrics</addtitle><date>1990-08</date><risdate>1990</risdate><volume>21</volume><issue>3</issue><spage>124</spage><epage>129</epage><pages>124-129</pages><issn>0174-304X</issn><eissn>1439-1899</eissn><abstract>Abstract
A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.
ABBREVIATIONS
Acquired immuno-deficiency syndrome: AIDSCytomegalovirus: CMV Human Immuno-Deficiency Virus: HIV Central Nervous System: CNS</abstract><cop>Germany</cop><pmid>2172857</pmid><doi>10.1055/s-2008-1071477</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0174-304X |
| ispartof | Neuropediatrics, 1990-08, Vol.21 (3), p.124-129 |
| issn | 0174-304X 1439-1899 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | AIDS-Related Complex - pathology AIDS/HIV Brain - pathology Cytomegalovirus Infections - congenital Cytomegalovirus Infections - pathology Encephalitis - congenital Encephalitis - pathology Female HIV Seropositivity - congenital Humans Inclusion Bodies, Viral - ultrastructure Infant Infant, Newborn Infant, Premature, Diseases - pathology Microscopy, Electron Opportunistic Infections - congenital Opportunistic Infections - pathology Original article |
| title | Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome |
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