Clearance of Rh D-positive red cells with monoclonal anti-D
Two human monoclonal antibodies, one IgG3 and one IgG1, with anti-Rh D specificity, were tested for their ability to clear red cells. Samples of red cells from 12 D-positive subjects were sensitised in vitro with various amounts of antibody, the number of antibody molecules bound to the cells was es...
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| Veröffentlicht in: | The Lancet (British edition) 1990-11, Vol.336 (8724), p.1147-1150 |
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| container_title | The Lancet (British edition) |
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| creator | Thomson, A. Contreras, M. Teesdale, P. Mollison, P.L. Gorick, B. Hughes-Jones, N.C. Kumpel, B. Chapman, G.E. Lane, R.S. |
| description | Two human monoclonal antibodies, one IgG3 and one IgG1, with anti-Rh D specificity, were tested for their ability to clear red cells. Samples of red cells from 12 D-positive subjects were sensitised in vitro with various amounts of antibody, the number of antibody molecules bound to the cells was estimated, and the cells were reinjected into the donor's circulation. Both antibodies mediated clearance but substantially fewer IgG3 than IgG1 antibody molecules were required to produce a given rate of clearance. The IgG3 antibody was slightly more effective than polyclonal anti-D, as judged by comparison with previously published results. Since there is believed to be an association between the rate of red cell clearance by anti-D and the ability of the antibody to suppress D immunisation, the IgG3 monoclonal antibody may prove suitable for the immunoprophylaxis of Rh D haemolytic disease. |
| doi_str_mv | 10.1016/0140-6736(90)92767-C |
| format | Article |
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Samples of red cells from 12 D-positive subjects were sensitised in vitro with various amounts of antibody, the number of antibody molecules bound to the cells was estimated, and the cells were reinjected into the donor's circulation. Both antibodies mediated clearance but substantially fewer IgG3 than IgG1 antibody molecules were required to produce a given rate of clearance. The IgG3 antibody was slightly more effective than polyclonal anti-D, as judged by comparison with previously published results. Since there is believed to be an association between the rate of red cell clearance by anti-D and the ability of the antibody to suppress D immunisation, the IgG3 monoclonal antibody may prove suitable for the immunoprophylaxis of Rh D haemolytic disease.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(90)92767-C</identifier><identifier>PMID: 1978026</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - therapeutic use ; Biological and medical sciences ; Blood ; Blood Donors ; Cell Survival - physiology ; Cellular biology ; Erythrocytes - drug effects ; Erythrocytes - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunization ; Immunohematology ; In Vitro Techniques ; Isoantibodies - administration & dosage ; Isoantibodies - therapeutic use ; Male ; Medical research ; Red blood cell immunology ; Rh-Hr Blood-Group System - immunology ; Rho(D) Immune Globulin ; Time Factors</subject><ispartof>The Lancet (British edition), 1990-11, Vol.336 (8724), p.1147-1150</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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Samples of red cells from 12 D-positive subjects were sensitised in vitro with various amounts of antibody, the number of antibody molecules bound to the cells was estimated, and the cells were reinjected into the donor's circulation. Both antibodies mediated clearance but substantially fewer IgG3 than IgG1 antibody molecules were required to produce a given rate of clearance. The IgG3 antibody was slightly more effective than polyclonal anti-D, as judged by comparison with previously published results. Since there is believed to be an association between the rate of red cell clearance by anti-D and the ability of the antibody to suppress D immunisation, the IgG3 monoclonal antibody may prove suitable for the immunoprophylaxis of Rh D haemolytic disease.</description><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Donors</subject><subject>Cell Survival - physiology</subject><subject>Cellular biology</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunohematology</subject><subject>In Vitro Techniques</subject><subject>Isoantibodies - administration & dosage</subject><subject>Isoantibodies - therapeutic use</subject><subject>Male</subject><subject>Medical research</subject><subject>Red blood cell immunology</subject><subject>Rh-Hr Blood-Group System - immunology</subject><subject>Rho(D) Immune Globulin</subject><subject>Time Factors</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1r1EAUhgdR6rb6DxSCYLEX0TPJfGQQCiW1VVgQRMG7Yb7CzpLNbGeSLf57J2ax4kWvzsV53peXB6FXGN5jwOwDYAIl4zV7J-BCVJzxsn2CVphwUlLCfz5Fq7_Ic3Sa0hYACAN6gk6w4A1UbIU-tr1TUQ3GFaErvm2K63Ifkh_9wRXR2cK4vk_FvR83xS4MwfRhUH2hhtGX1y_Qs071yb083jP04-bT9_Zzuf56-6W9WpeGYDKWhltbaSO6qjNaAa0rKlyDsdVEN7qxllaswoZryyjuDFhtqIWGWUoba-q6PkPnS-8-hrvJpVHufJqHqcGFKckGQPAK8wy--Q_chinmwUli0YgMEZwhskAmhpSi6-Q--p2KvyQGOYuVszU5W5MC5B-xss2x18fuSe-cfQgtJvP_7fGvklF9Nzv16R-M1IxSkbnLhXPZ2MG7KJPxLvu3PjozShv840N-A7hBkto</recordid><startdate>19901110</startdate><enddate>19901110</enddate><creator>Thomson, A.</creator><creator>Contreras, M.</creator><creator>Teesdale, P.</creator><creator>Mollison, P.L.</creator><creator>Gorick, B.</creator><creator>Hughes-Jones, N.C.</creator><creator>Kumpel, B.</creator><creator>Chapman, G.E.</creator><creator>Lane, R.S.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19901110</creationdate><title>Clearance of Rh D-positive red cells with monoclonal anti-D</title><author>Thomson, A. ; Contreras, M. ; Teesdale, P. ; Mollison, P.L. ; Gorick, B. ; Hughes-Jones, N.C. ; Kumpel, B. ; Chapman, G.E. ; Lane, R.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-c7dd2bc9f2fcba053259e811db4b8b8dd52621c7bd651fc0dbc5d086d558dc333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Donors</topic><topic>Cell Survival - physiology</topic><topic>Cellular biology</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - immunology</topic><topic>Fundamental and applied biological sciences. 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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1990-11, Vol.336 (8724), p.1147-1150 |
| issn | 0140-6736 1474-547X |
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| subjects | Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Blood Blood Donors Cell Survival - physiology Cellular biology Erythrocytes - drug effects Erythrocytes - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunization Immunohematology In Vitro Techniques Isoantibodies - administration & dosage Isoantibodies - therapeutic use Male Medical research Red blood cell immunology Rh-Hr Blood-Group System - immunology Rho(D) Immune Globulin Time Factors |
| title | Clearance of Rh D-positive red cells with monoclonal anti-D |
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