Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs
The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 μg/kg) significantly increased blood flows in the portal vein (...
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| Veröffentlicht in: | Life sciences (1973) 1990, Vol.47 (13), p.1115-1119 |
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| container_issue | 13 |
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| container_title | Life sciences (1973) |
| container_volume | 47 |
| creator | Sumi, Shoichiro Inoue, Kazutomo Hosotani, Ryo Kogire, Masafumi Doi, Ryuichiro Yun, Mitsutoshi Higashide, Shunichi Minote, Hideshi Takaori, Kyoichi Kaji, Hiromu Uchida, Kotaro Tobe, Takayoshi |
| description | The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 μg/kg) significantly increased blood flows in the portal vein (36.9±7.4% at 1 μg/kg) and the superior mesenteric artery (49.0±16.8% at 1 μg/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4±1.2% at 1 μg/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow. |
| doi_str_mv | 10.1016/0024-3205(90)90170-V |
| format | Article |
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Human epidermal growth factor (0.1, 0.5 and 1 μg/kg) significantly increased blood flows in the portal vein (36.9±7.4% at 1 μg/kg) and the superior mesenteric artery (49.0±16.8% at 1 μg/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4±1.2% at 1 μg/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(90)90170-V</identifier><identifier>PMID: 2233130</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Blood Pressure - drug effects ; Dogs ; Epidermal Growth Factor - administration & dosage ; Epidermal Growth Factor - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodynamics. Rheology ; Injections, Intravenous ; Male ; Mesenteric Arteries ; Portal Vein ; Recombinant Proteins - pharmacology ; Splanchnic Circulation - drug effects ; Vertebrates: cardiovascular system</subject><ispartof>Life sciences (1973), 1990, Vol.47 (13), p.1115-1119</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-ace025f6983e05a4008b9e4a5be4d7945561cfb8104cf7ac0514a5c0b8703d993</citedby><cites>FETCH-LOGICAL-c453t-ace025f6983e05a4008b9e4a5be4d7945561cfb8104cf7ac0514a5c0b8703d993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(90)90170-V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19384109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2233130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sumi, Shoichiro</creatorcontrib><creatorcontrib>Inoue, Kazutomo</creatorcontrib><creatorcontrib>Hosotani, Ryo</creatorcontrib><creatorcontrib>Kogire, Masafumi</creatorcontrib><creatorcontrib>Doi, Ryuichiro</creatorcontrib><creatorcontrib>Yun, Mitsutoshi</creatorcontrib><creatorcontrib>Higashide, Shunichi</creatorcontrib><creatorcontrib>Minote, Hideshi</creatorcontrib><creatorcontrib>Takaori, Kyoichi</creatorcontrib><creatorcontrib>Kaji, Hiromu</creatorcontrib><creatorcontrib>Uchida, Kotaro</creatorcontrib><creatorcontrib>Tobe, Takayoshi</creatorcontrib><title>Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 μg/kg) significantly increased blood flows in the portal vein (36.9±7.4% at 1 μg/kg) and the superior mesenteric artery (49.0±16.8% at 1 μg/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4±1.2% at 1 μg/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Dogs</subject><subject>Epidermal Growth Factor - administration & dosage</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics. Rheology</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Mesenteric Arteries</subject><subject>Portal Vein</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Splanchnic Circulation - drug effects</subject><subject>Vertebrates: cardiovascular system</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKkvhH4DkC6g9BMaxncQXJFRtC1IlOECvljMZd42SeLETEP8eL7sqN04jzfuhVw9jLwW8FSCadwC1qmQN-sLApQHRQnX3iG1E15oKGikes82D5Sl7lvN3ANC6lWfsrK6lFBI27MvWe8KFR8936-RmTvswUJrcyO9T_LXsuHe4xMQvdtub60seZ573o5txNwfkGBKuo1tCeYeZD_E-P2dPvBszvTjdc_btevv16mN1-_nm09WH2wqVlkvlkKDWvjGdJNBOAXS9IeV0T2pojdK6Eej7ToBC3zoELYqI0HctyMEYec7eHHv3Kf5YKS92ChlpLNsortl2AKbRRhSjOhoxxZwTebtPYXLptxVgDyDtgZI9ULIG7F-Q9q7EXp36136i4SF0Ilf01yfdZXSjT4VJyP-6jeyUgMPO90cfFRg_AyWbMdCMNIRUwNshhv8P-QMCmI2x</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Sumi, Shoichiro</creator><creator>Inoue, Kazutomo</creator><creator>Hosotani, Ryo</creator><creator>Kogire, Masafumi</creator><creator>Doi, Ryuichiro</creator><creator>Yun, Mitsutoshi</creator><creator>Higashide, Shunichi</creator><creator>Minote, Hideshi</creator><creator>Takaori, Kyoichi</creator><creator>Kaji, Hiromu</creator><creator>Uchida, Kotaro</creator><creator>Tobe, Takayoshi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs</title><author>Sumi, Shoichiro ; Inoue, Kazutomo ; Hosotani, Ryo ; Kogire, Masafumi ; Doi, Ryuichiro ; Yun, Mitsutoshi ; Higashide, Shunichi ; Minote, Hideshi ; Takaori, Kyoichi ; Kaji, Hiromu ; Uchida, Kotaro ; Tobe, Takayoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-ace025f6983e05a4008b9e4a5be4d7945561cfb8104cf7ac0514a5c0b8703d993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Dogs</topic><topic>Epidermal Growth Factor - administration & dosage</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics. Rheology</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Mesenteric Arteries</topic><topic>Portal Vein</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Splanchnic Circulation - drug effects</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sumi, Shoichiro</creatorcontrib><creatorcontrib>Inoue, Kazutomo</creatorcontrib><creatorcontrib>Hosotani, Ryo</creatorcontrib><creatorcontrib>Kogire, Masafumi</creatorcontrib><creatorcontrib>Doi, Ryuichiro</creatorcontrib><creatorcontrib>Yun, Mitsutoshi</creatorcontrib><creatorcontrib>Higashide, Shunichi</creatorcontrib><creatorcontrib>Minote, Hideshi</creatorcontrib><creatorcontrib>Takaori, Kyoichi</creatorcontrib><creatorcontrib>Kaji, Hiromu</creatorcontrib><creatorcontrib>Uchida, Kotaro</creatorcontrib><creatorcontrib>Tobe, Takayoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sumi, Shoichiro</au><au>Inoue, Kazutomo</au><au>Hosotani, Ryo</au><au>Kogire, Masafumi</au><au>Doi, Ryuichiro</au><au>Yun, Mitsutoshi</au><au>Higashide, Shunichi</au><au>Minote, Hideshi</au><au>Takaori, Kyoichi</au><au>Kaji, Hiromu</au><au>Uchida, Kotaro</au><au>Tobe, Takayoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1990</date><risdate>1990</risdate><volume>47</volume><issue>13</issue><spage>1115</spage><epage>1119</epage><pages>1115-1119</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 μg/kg) significantly increased blood flows in the portal vein (36.9±7.4% at 1 μg/kg) and the superior mesenteric artery (49.0±16.8% at 1 μg/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4±1.2% at 1 μg/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2233130</pmid><doi>10.1016/0024-3205(90)90170-V</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Flow Velocity - drug effects Blood Pressure - drug effects Dogs Epidermal Growth Factor - administration & dosage Epidermal Growth Factor - pharmacology Female Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Injections, Intravenous Male Mesenteric Arteries Portal Vein Recombinant Proteins - pharmacology Splanchnic Circulation - drug effects Vertebrates: cardiovascular system |
| title | Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs |
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