Injectable Contraceptive Use and Genital Ulcer Disease during the Early Phase of HIV-1 Infection Increase Plasma Virus Load in Women
We examined the association between host factors present near the time of human immunodeficiency virus type 1 (HIV-1) acquisition and subsequent virus loads, in a prospective cohort study of women in Mombasa, Kenya. Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-...
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| Veröffentlicht in: | The Journal of infectious diseases 2004-01, Vol.189 (2), p.303-311 |
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| creator | Lavreys, Ludo Baeten, Jared M. Kreiss, Joan K. Richardson, Barbra A. Chohan, Bhavna H. Hassan, Wisal Panteleeff, Dana D. Mandaliya, Kishorchandra Ndinya-Achola, Jeckoniah O. Overbaugh, Julie |
| description | We examined the association between host factors present near the time of human immunodeficiency virus type 1 (HIV-1) acquisition and subsequent virus loads, in a prospective cohort study of women in Mombasa, Kenya. Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected ⩾4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection |
| doi_str_mv | 10.1086/380974 |
| format | Article |
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Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected ⩾4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/380974</identifier><identifier>PMID: 14722896</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - virology ; Adult ; AIDS ; Biological and medical sciences ; Blood plasma ; Cohort Studies ; Contraception ; Contraceptive Agents, Female - administration & dosage ; depot medroxyprogesterone acetate ; Female ; Fundamental and applied biological sciences. Psychology ; Genital Diseases, Female - virology ; HIV ; HIV 1 ; HIV-1 - isolation & purification ; HIV/AIDS ; Human immunodeficiency virus 1 ; Humans ; Infections ; Infectious diseases ; Injections ; Medical sciences ; Medroxyprogesterone Acetate - administration & dosage ; Microbiology ; Miscellaneous ; Multivariate Analysis ; Prospective Studies ; RNA ; RNA, Viral - blood ; Sexual Behavior ; Sexually transmitted diseases ; Ulcer - virology ; Viral diseases ; Viral Load ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2004-01, Vol.189 (2), p.303-311</ispartof><rights>Copyright 2004 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 15 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-8d2565e89e4b57a4108a4e815d5445c080784627610bdf30210da7f8b91e5193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075883$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075883$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15662914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14722896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lavreys, Ludo</creatorcontrib><creatorcontrib>Baeten, Jared M.</creatorcontrib><creatorcontrib>Kreiss, Joan K.</creatorcontrib><creatorcontrib>Richardson, Barbra A.</creatorcontrib><creatorcontrib>Chohan, Bhavna H.</creatorcontrib><creatorcontrib>Hassan, Wisal</creatorcontrib><creatorcontrib>Panteleeff, Dana D.</creatorcontrib><creatorcontrib>Mandaliya, Kishorchandra</creatorcontrib><creatorcontrib>Ndinya-Achola, Jeckoniah O.</creatorcontrib><creatorcontrib>Overbaugh, Julie</creatorcontrib><title>Injectable Contraceptive Use and Genital Ulcer Disease during the Early Phase of HIV-1 Infection Increase Plasma Virus Load in Women</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We examined the association between host factors present near the time of human immunodeficiency virus type 1 (HIV-1) acquisition and subsequent virus loads, in a prospective cohort study of women in Mombasa, Kenya. Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected ⩾4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection</description><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Adult</subject><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>Cohort Studies</subject><subject>Contraception</subject><subject>Contraceptive Agents, Female - administration & dosage</subject><subject>depot medroxyprogesterone acetate</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genital Diseases, Female - virology</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV-1 - isolation & purification</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - administration & dosage</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Multivariate Analysis</subject><subject>Prospective Studies</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>Sexual Behavior</subject><subject>Sexually transmitted diseases</subject><subject>Ulcer - virology</subject><subject>Viral diseases</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEYhQdR7Fr1HyhR0LvRfH9cytp2FxZcsK3Sm5CdecdmnUnWZEbsvT_caWfpgiBeveE9T05yOEXxnOB3BGv5nmlsFH9QzIhgqpSSsIfFDGNKS6KNOSqe5LzFGHMm1ePiiHBFqTZyVvxehi1Uvdu0gOYx9MlVsOv9T0AXGZALNTqD4HvXoou2goQ--gxuVOoh-fAN9deATlxqb9D6-nYdG7RYXpYELUMz2voYxlOV7q6sW5c7hy59GjJaRVcjH9CX2EF4WjxqXJvh2X4eF-enJ-fzRbn6dLacf1iVFdekL3VNhRSgDfCNUI6PwR0HTUQtOBcV1lhpLqmSBG_qhmFKcO1UozeGgCCGHRdvJ9tdij8GyL3tfK6gbV2AOGSrMTYSC_lfkBiqCCN8BF__BW7jkMKYwVLKDDZCi4NblWLOCRq7S75z6cYSbG_Ls1N5I_hy7zZsOqgP2L6tEXizB1yuXNskFyqfD5yQkpq7b72auDjs_v3Yi4nZ5j6me4phrITWbNTLSfe5h1_3ukvfrVRMCbv4emWvxKkU_DO3a_YHy5fAeQ</recordid><startdate>20040115</startdate><enddate>20040115</enddate><creator>Lavreys, Ludo</creator><creator>Baeten, Jared M.</creator><creator>Kreiss, Joan K.</creator><creator>Richardson, Barbra A.</creator><creator>Chohan, Bhavna H.</creator><creator>Hassan, Wisal</creator><creator>Panteleeff, Dana D.</creator><creator>Mandaliya, Kishorchandra</creator><creator>Ndinya-Achola, Jeckoniah O.</creator><creator>Overbaugh, Julie</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040115</creationdate><title>Injectable Contraceptive Use and Genital Ulcer Disease during the Early Phase of HIV-1 Infection Increase Plasma Virus Load in Women</title><author>Lavreys, Ludo ; Baeten, Jared M. ; Kreiss, Joan K. ; Richardson, Barbra A. ; Chohan, Bhavna H. ; Hassan, Wisal ; Panteleeff, Dana D. ; Mandaliya, Kishorchandra ; Ndinya-Achola, Jeckoniah O. ; Overbaugh, Julie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-8d2565e89e4b57a4108a4e815d5445c080784627610bdf30210da7f8b91e5193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>Adult</topic><topic>AIDS</topic><topic>Biological and medical sciences</topic><topic>Blood plasma</topic><topic>Cohort Studies</topic><topic>Contraception</topic><topic>Contraceptive Agents, Female - administration & dosage</topic><topic>depot medroxyprogesterone acetate</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected ⩾4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14722896</pmid><doi>10.1086/380974</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - virology Adult AIDS Biological and medical sciences Blood plasma Cohort Studies Contraception Contraceptive Agents, Female - administration & dosage depot medroxyprogesterone acetate Female Fundamental and applied biological sciences. Psychology Genital Diseases, Female - virology HIV HIV 1 HIV-1 - isolation & purification HIV/AIDS Human immunodeficiency virus 1 Humans Infections Infectious diseases Injections Medical sciences Medroxyprogesterone Acetate - administration & dosage Microbiology Miscellaneous Multivariate Analysis Prospective Studies RNA RNA, Viral - blood Sexual Behavior Sexually transmitted diseases Ulcer - virology Viral diseases Viral Load Virology Viruses |
| title | Injectable Contraceptive Use and Genital Ulcer Disease during the Early Phase of HIV-1 Infection Increase Plasma Virus Load in Women |
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