Isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal antiinflammatory drugs

An isolated perfused rat kidney (IPK) preparation is described in which renal perfusion flow, perfusion pressure, urinary flow, urinary pH, and glomerular filtration rate (GFR) are recorded continuously during the perfusion experiment. The usefulness of this IPK system in studying the renal handling...

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Veröffentlicht in:	Journal of pharmacological methods 1990-09, Vol.24 (2), p.89-103
Hauptverfasser:	Cox, Peter G.F., Moons, Miek M., Slegers, Jan F.G., Russel, Frans G.M., Van Ginneken, Cees A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - urine Glomerular Filtration Rate Hippurates - metabolism Hippurates - urine Isolated perfused rat kidney Kidney - drug effects Kidney - metabolism Kidney - physiology Kidney function Male Naproxen - metabolism Naproxen - urine Nonsteroidal antiinflammatory drugs Perfusion Rats Rats, Inbred Strains Renal handling Salicylates - metabolism Salicylates - urine Salicylic Acid
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