Time course of sprouting during muscle reinnervation in vitamin E-deficient rats
A typical aspect of motoneuron plasticity is the sprouting which occurs during muscle reinnervation, resulting in a transitory multiple innervation of the muscle cells. In order to verify the effect of a decreased protection from free radical attack on the sprouting, the multiple innervation in the...
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| Veröffentlicht in: | Muscle & nerve 1990-11, Vol.13 (11), p.1027-1031 |
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| container_title | Muscle & nerve |
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| creator | Cuppini, Riccardo Cecchini, Tiziana Cuppini, Carla Ciaroni, Sandra Del Grande, Paolo |
| description | A typical aspect of motoneuron plasticity is the sprouting which occurs during muscle reinnervation, resulting in a transitory multiple innervation of the muscle cells. In order to verify the effect of a decreased protection from free radical attack on the sprouting, the multiple innervation in the extensor digitorum longus muscle, following sciatic nerve crush and regeneration, was studied in vitamin E‐deficient rats. Thus, the innervated end‐plates and the end‐plates with multiple innervation were studied with histochemical and electrophysiological techniques. The percentage of innervated end‐plates was similar in both groups at 30 as well as at 60 days after nerve crush. Nevertheless, multiple innervation was found in a larger part of the muscle and it lasted longer in the deficient rats. This finding is discussed in relation to some of the major hypotheses of sprouting; it may be relevant in the treatment of some lesions of peripheral nerve. |
| doi_str_mv | 10.1002/mus.880131105 |
| format | Article |
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In order to verify the effect of a decreased protection from free radical attack on the sprouting, the multiple innervation in the extensor digitorum longus muscle, following sciatic nerve crush and regeneration, was studied in vitamin E‐deficient rats. Thus, the innervated end‐plates and the end‐plates with multiple innervation were studied with histochemical and electrophysiological techniques. The percentage of innervated end‐plates was similar in both groups at 30 as well as at 60 days after nerve crush. Nevertheless, multiple innervation was found in a larger part of the muscle and it lasted longer in the deficient rats. 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In order to verify the effect of a decreased protection from free radical attack on the sprouting, the multiple innervation in the extensor digitorum longus muscle, following sciatic nerve crush and regeneration, was studied in vitamin E‐deficient rats. Thus, the innervated end‐plates and the end‐plates with multiple innervation were studied with histochemical and electrophysiological techniques. The percentage of innervated end‐plates was similar in both groups at 30 as well as at 60 days after nerve crush. Nevertheless, multiple innervation was found in a larger part of the muscle and it lasted longer in the deficient rats. This finding is discussed in relation to some of the major hypotheses of sprouting; it may be relevant in the treatment of some lesions of peripheral nerve.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Hindlimb</subject><subject>In Vitro Techniques</subject><subject>Motor Endplate - physiopathology</subject><subject>multiple innervation</subject><subject>Muscle Contraction</subject><subject>muscle reinnervation</subject><subject>Muscles - innervation</subject><subject>Muscles - physiopathology</subject><subject>Nerve Crush</subject><subject>Nerve Regeneration</subject><subject>neuromuscular junction</subject><subject>Neuronal Plasticity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - physiopathology</subject><subject>vitamin E</subject><subject>Vitamin E Deficiency - physiopathology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EKqUwMiJlYgtcx0lsjwjxqngKEBWL5bjXyJAH2Emh_55ULYiJ6Qznu5-uDiG7FA4oQHJYdeFACKCMUsjWyJCC5HGaSbFOhkBTEedMTjbJVgivAEBFzgdkkCSMiUwOye2DqzAyTecDRo2NwrtvutbVL9G084vo9abEyKOra_Qz3bqmjlwdzVyrqz5P4ilaZxzWbeR1G7bJhtVlwJ1Vjsjj6cnD8Xl8eXN2cXx0GRvG0yxGLKwFqq1gJrdMZih5nrIMKc2NYEXfSYmQFFQjaMaL3FqepjkUhWGIgo3I_tLbP_zRYWhV5YLBstQ1Nl1QAkCmFBZgvASNb0LwaNW7d5X2c0VBLRZU1QL_WbDn91birqhw-kuvJut7vuw_XYnz_2Xq6vH-r3n1iQstfv1eav-mcs54pp6uz9Q9nTyPk-ROjdk3ONaM3w</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>Cuppini, Riccardo</creator><creator>Cecchini, Tiziana</creator><creator>Cuppini, Carla</creator><creator>Ciaroni, Sandra</creator><creator>Del Grande, Paolo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199011</creationdate><title>Time course of sprouting during muscle reinnervation in vitamin E-deficient rats</title><author>Cuppini, Riccardo ; Cecchini, Tiziana ; Cuppini, Carla ; Ciaroni, Sandra ; Del Grande, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3745-eebff01af83c6f395e976435e116c83bf0199e02b1ae0a37b6ff74460bbc3ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Hindlimb</topic><topic>In Vitro Techniques</topic><topic>Motor Endplate - physiopathology</topic><topic>multiple innervation</topic><topic>Muscle Contraction</topic><topic>muscle reinnervation</topic><topic>Muscles - innervation</topic><topic>Muscles - physiopathology</topic><topic>Nerve Crush</topic><topic>Nerve Regeneration</topic><topic>neuromuscular junction</topic><topic>Neuronal Plasticity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic Nerve - physiopathology</topic><topic>vitamin E</topic><topic>Vitamin E Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuppini, Riccardo</creatorcontrib><creatorcontrib>Cecchini, Tiziana</creatorcontrib><creatorcontrib>Cuppini, Carla</creatorcontrib><creatorcontrib>Ciaroni, Sandra</creatorcontrib><creatorcontrib>Del Grande, Paolo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuppini, Riccardo</au><au>Cecchini, Tiziana</au><au>Cuppini, Carla</au><au>Ciaroni, Sandra</au><au>Del Grande, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time course of sprouting during muscle reinnervation in vitamin E-deficient rats</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1990-11</date><risdate>1990</risdate><volume>13</volume><issue>11</issue><spage>1027</spage><epage>1031</epage><pages>1027-1031</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>A typical aspect of motoneuron plasticity is the sprouting which occurs during muscle reinnervation, resulting in a transitory multiple innervation of the muscle cells. 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| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 1990-11, Vol.13 (11), p.1027-1031 |
| issn | 0148-639X 1097-4598 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Action Potentials Animals Hindlimb In Vitro Techniques Motor Endplate - physiopathology multiple innervation Muscle Contraction muscle reinnervation Muscles - innervation Muscles - physiopathology Nerve Crush Nerve Regeneration neuromuscular junction Neuronal Plasticity Rats Rats, Inbred Strains Sciatic Nerve - injuries Sciatic Nerve - physiopathology vitamin E Vitamin E Deficiency - physiopathology |
| title | Time course of sprouting during muscle reinnervation in vitamin E-deficient rats |
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