Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons
Risk factors for severe respiratory syncytial virus (RSV) infection were determined in 3 cohorts of adults during 2 consecutive winters (1999–2000 and 2000–2001) in Rochester, New York. Community-dwelling healthy persons ⩾65 years old and persons >21 years old who had underlying symptomatic cardi...
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Veröffentlicht in: | The Journal of infectious diseases 2004-01, Vol.189 (2), p.233-238 |
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description | Risk factors for severe respiratory syncytial virus (RSV) infection were determined in 3 cohorts of adults during 2 consecutive winters (1999–2000 and 2000–2001) in Rochester, New York. Community-dwelling healthy persons ⩾65 years old and persons >21 years old who had underlying symptomatic cardiopulmonary conditions were prospectively evaluated for RSV infection. Evidence of infection was also sought in persons who were ⩾65 years old or had underlying cardiopulmonary disease and who were hospitalized with acute respiratory symptoms. Sixty-nine RSV infections were identified by culture, reverse-transcription polymerase chain reaction, or serologic testing in the prospective groups, and 61 were identified in the hospitalized group. The presence of underlying chronic pulmonary disease (odds ratio [OR], 3.97), functional disability (OR, 1.67/integer increase in Instruments of Activities of Daily Living score), and low serum neutralizing antibody titer (OR, 5.89) were each independently associated with increased risk of severe disease, defined as “hospitalization with RSV infection.” These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations |
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Community-dwelling healthy persons ⩾65 years old and persons >21 years old who had underlying symptomatic cardiopulmonary conditions were prospectively evaluated for RSV infection. Evidence of infection was also sought in persons who were ⩾65 years old or had underlying cardiopulmonary disease and who were hospitalized with acute respiratory symptoms. Sixty-nine RSV infections were identified by culture, reverse-transcription polymerase chain reaction, or serologic testing in the prospective groups, and 61 were identified in the hospitalized group. The presence of underlying chronic pulmonary disease (odds ratio [OR], 3.97), functional disability (OR, 1.67/integer increase in Instruments of Activities of Daily Living score), and low serum neutralizing antibody titer (OR, 5.89) were each independently associated with increased risk of severe disease, defined as “hospitalization with RSV infection.” These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/380907</identifier><identifier>PMID: 14722887</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Aged ; Aged, 80 and over ; Antibodies, Viral - blood ; Biological and medical sciences ; Diseases ; Female ; Fundamental and applied biological sciences. Psychology ; Hospitalization ; Human respiratory syncytial virus ; Humans ; Infections ; Infectious diseases ; Lung diseases ; Male ; Medical sciences ; Microbiology ; Neutralizing antibodies ; Older adults ; Predisposing factors ; Respiratory syncytial virus ; Respiratory syncytial virus infections ; Respiratory Syncytial Virus Infections - etiology ; Respiratory Syncytial Virus Infections - immunology ; Respiratory syncytial viruses ; Risk Factors ; Viruses</subject><ispartof>The Journal of infectious diseases, 2004-01, Vol.189 (2), p.233-238</ispartof><rights>Copyright 2004 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 15 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-427ce478020d444d54c59a3de6e0fd197bb6ba0f1eb67a0b0de05d0e3c4f65823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075874$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075874$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15662905$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14722887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walsh, Edward E.</creatorcontrib><creatorcontrib>Peterson, Derick R.</creatorcontrib><creatorcontrib>Falsey, Ann R.</creatorcontrib><title>Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Risk factors for severe respiratory syncytial virus (RSV) infection were determined in 3 cohorts of adults during 2 consecutive winters (1999–2000 and 2000–2001) in Rochester, New York. Community-dwelling healthy persons ⩾65 years old and persons >21 years old who had underlying symptomatic cardiopulmonary conditions were prospectively evaluated for RSV infection. Evidence of infection was also sought in persons who were ⩾65 years old or had underlying cardiopulmonary disease and who were hospitalized with acute respiratory symptoms. Sixty-nine RSV infections were identified by culture, reverse-transcription polymerase chain reaction, or serologic testing in the prospective groups, and 61 were identified in the hospitalized group. The presence of underlying chronic pulmonary disease (odds ratio [OR], 3.97), functional disability (OR, 1.67/integer increase in Instruments of Activities of Daily Living score), and low serum neutralizing antibody titer (OR, 5.89) were each independently associated with increased risk of severe disease, defined as “hospitalization with RSV infection.” These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hospitalization</subject><subject>Human respiratory syncytial virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Neutralizing antibodies</subject><subject>Older adults</subject><subject>Predisposing factors</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory syncytial virus infections</subject><subject>Respiratory Syncytial Virus Infections - etiology</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory syncytial viruses</subject><subject>Risk Factors</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgil2r_gNlFPRu9OQ7uZTSbSsVS1dFehMymTOQ7ezMmsxI5993ZJcuCOJVIO_DG3IOIS8pfKBg1EduwIJ-RBZUcl0qRfljsgBgrKTG2iPyLOc1AAiu9FNyRIVmzBi9IFfXMd8WSx-GPuWi6VOxwt-YsLjGvI3Jz9dTsZq6MA3Rt8WPmMZcXHQNhiH2XRG74rStMbVTcYUp911-Tp40vs34Yn8ek-_L028n5-Xl17OLk0-XZRCGDqVgOqDQBhjUQohaiiCt5zUqhKamVleVqjw0FCulPVRQI8gakAfRKGkYPybvd73b1P8aMQ9uE3PAtvUd9mN2BsAKMPa_kFqmKbd8hm__gut-TN38CccYtxSEVIe2kPqcEzZum-LGp8lRcH824XabmOHrfdtYbbA-sP3oZ_BuD3wOvm2S70LMByeVYhbk7N7sXD9u__3Yq51Z53lhD4oDaGm0mPNyl8c84N1D7tOtU5pr6c5_3rjPXyxf0eWNO-P3WwyxPg</recordid><startdate>20040115</startdate><enddate>20040115</enddate><creator>Walsh, Edward E.</creator><creator>Peterson, Derick R.</creator><creator>Falsey, Ann R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040115</creationdate><title>Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons</title><author>Walsh, Edward E. ; Peterson, Derick R. ; Falsey, Ann R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-427ce478020d444d54c59a3de6e0fd197bb6ba0f1eb67a0b0de05d0e3c4f65823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hospitalization</topic><topic>Human respiratory syncytial virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Neutralizing antibodies</topic><topic>Older adults</topic><topic>Predisposing factors</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory syncytial virus infections</topic><topic>Respiratory Syncytial Virus Infections - etiology</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory syncytial viruses</topic><topic>Risk Factors</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walsh, Edward E.</creatorcontrib><creatorcontrib>Peterson, Derick R.</creatorcontrib><creatorcontrib>Falsey, Ann R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walsh, Edward E.</au><au>Peterson, Derick R.</au><au>Falsey, Ann R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-01-15</date><risdate>2004</risdate><volume>189</volume><issue>2</issue><spage>233</spage><epage>238</epage><pages>233-238</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Risk factors for severe respiratory syncytial virus (RSV) infection were determined in 3 cohorts of adults during 2 consecutive winters (1999–2000 and 2000–2001) in Rochester, New York. Community-dwelling healthy persons ⩾65 years old and persons >21 years old who had underlying symptomatic cardiopulmonary conditions were prospectively evaluated for RSV infection. Evidence of infection was also sought in persons who were ⩾65 years old or had underlying cardiopulmonary disease and who were hospitalized with acute respiratory symptoms. Sixty-nine RSV infections were identified by culture, reverse-transcription polymerase chain reaction, or serologic testing in the prospective groups, and 61 were identified in the hospitalized group. The presence of underlying chronic pulmonary disease (odds ratio [OR], 3.97), functional disability (OR, 1.67/integer increase in Instruments of Activities of Daily Living score), and low serum neutralizing antibody titer (OR, 5.89) were each independently associated with increased risk of severe disease, defined as “hospitalization with RSV infection.” These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14722887</pmid><doi>10.1086/380907</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Antibodies, Viral - blood Biological and medical sciences Diseases Female Fundamental and applied biological sciences. Psychology Hospitalization Human respiratory syncytial virus Humans Infections Infectious diseases Lung diseases Male Medical sciences Microbiology Neutralizing antibodies Older adults Predisposing factors Respiratory syncytial virus Respiratory syncytial virus infections Respiratory Syncytial Virus Infections - etiology Respiratory Syncytial Virus Infections - immunology Respiratory syncytial viruses Risk Factors Viruses |
title | Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons |
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