Catecholamine-Induced Vascular Wall Growth Is Dependent on Generation of Reactive Oxygen Species

ABSTRACT—α1-Adrenoceptor–dependent proliferation of vascular smooth muscle cells (VSMCs) is strongly augmented by vascular injury, and may contribute to intimal growth and lumen loss. Because reactive oxygen species (ROS) are increased by injury and have been implicated as second messengers in proli...

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Veröffentlicht in:	Circulation research 2004-01, Vol.94 (1), p.37-45
Hauptverfasser:	Bleeke, Tina, Zhang, Hua, Madamanchi, Nageswara, Patterson, Cam, Faber, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists - pharmacology Angioplasty, Balloon Animals Antioxidants - pharmacology Aorta - cytology Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - metabolism Biological and medical sciences Catalase - pharmacology Cell Division - drug effects Cells, Cultured Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism NADPH Oxidases - antagonists & inhibitors Norepinephrine - antagonists & inhibitors Norepinephrine - pharmacology Organ Culture Techniques Phenylephrine - antagonists & inhibitors Phenylephrine - pharmacology Phosphoproteins - physiology Prazosin - pharmacology Rats Reactive Oxygen Species - metabolism Tunica Media - cytology Tunica Media - metabolism Vertebrates: cardiovascular system
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