Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy

ABSTRACT—Calcineurin (PP2B) is a calcium/calmodulin-activated, serine-threonine phosphatase that transmits signals to the nucleus through the dephosphorylation and translocation of nuclear factor of activated T cell (NFAT) transcription factors. Whereas calcineurin-NFAT signaling has been implicated...

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Veröffentlicht in:	Circulation research 2004-01, Vol.94 (1), p.110-118
Hauptverfasser:	Wilkins, Benjamin J, Dai, Yan-Shan, Bueno, Orlando F, Parsons, Stephanie A, Xu, Jian, Plank, David M, Jones, Fred, Kimball, Thomas R, Molkentin, Jeffery D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcineurin - metabolism Cardiology. Vascular system Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cell Size Cells, Cultured DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Fundamental and applied biological sciences. Psychology Genes, Reporter Heart Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Insulin-Like Growth Factor I - pharmacology Luciferases - genetics Male Medical sciences Mice Mice, Transgenic Myocardium - cytology Myocardium - metabolism Myocardium - pathology NFATC Transcription Factors Nuclear Proteins Physical Conditioning, Animal Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Vertebrates: cardiovascular system
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