Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction
: Regenerative medicine via tissue engineering is a newly developed medical field based on the use of somatic stem cells to generate biological substitutes and improve tissue functions. The achievement of these objectives depends on two important factors: stem cells, which are high in proliferabili...
Gespeichert in:
| Veröffentlicht in: | Artificial organs 2004-01, Vol.28 (1), p.22-27 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 27 |
|---|---|
| container_issue | 1 |
| container_start_page | 22 |
| container_title | Artificial organs |
| container_volume | 28 |
| creator | Kinoshita, Shigeru Nakamura, Takahiro |
| description | : Regenerative medicine via tissue engineering is a newly developed medical field based on the use of somatic stem cells to generate biological substitutes and improve tissue functions. The achievement of these objectives depends on two important factors: stem cells, which are high in proliferability and differentiability, and the substrates that support them. In order to reconstruct the ocular surface in patients with severe ocular surface diseases, we decided to investigate the feasibility of human amniotic membrane as an epithelial carrier, and found that denuded amniotic membrane was the most appropriate substrate for this purpose. To develop the surgical treatment using denuded amniotic membrane as a carrier, we established the tissue engineering system for making transplantable epithelial sheets of either corneal or oral mucosal epithelial cells for ocular surface reconstruction. |
| doi_str_mv | 10.1111/j.1525-1594.2004.07319.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80090585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17751357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5009-740ffd596aa74a867090232f5b93d515e27e8eaa3d3bf77739063d4ed9ab42a43</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhS0EotvSv4B84pYwju04OXAo23ZBalmpXdTeLG8yUbNk49R2yvbf12FX5Qi-eKT53szoPUIog5TF93mTMpnJhMlSpBmASEFxVqa7N2T22nhLZsBySGQu7o_IsfcbAFAC8vfkiAmVQVaIGanP8Qk7O2yxD9Q2dD52oX0yAWt6PVbWm45eDG14wK6N5e0DYqArZ3o_dKYPJrS2p411dFmNnXH0dnSNqZDeYGV7H9xYTcQH8q4xncfTw39Cfl5erObfkqvl4vv87CqpJECZxOOappZlbowSpsgVlJDxrJHrkteSScwUFmgMr_m6UUrxEnJeC6xLsxaZEfyEfNrPHZx9HNEHvW19hV08Fe3odRG3gCzkP0GmlGRcqggWe7By1nuHjR5cuzXuWTPQUxR6oyfH9eS4nqLQf6LQuyj9eNgxrrdY_xUevI_Alz3wu-3w-b8H67PlzVRFfbLXtz7g7lVv3C-dK66kvvux0PJarRYc7vVX_gJUcKej</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17751357</pqid></control><display><type>article</type><title>Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kinoshita, Shigeru ; Nakamura, Takahiro</creator><creatorcontrib>Kinoshita, Shigeru ; Nakamura, Takahiro</creatorcontrib><description>: Regenerative medicine via tissue engineering is a newly developed medical field based on the use of somatic stem cells to generate biological substitutes and improve tissue functions. The achievement of these objectives depends on two important factors: stem cells, which are high in proliferability and differentiability, and the substrates that support them. In order to reconstruct the ocular surface in patients with severe ocular surface diseases, we decided to investigate the feasibility of human amniotic membrane as an epithelial carrier, and found that denuded amniotic membrane was the most appropriate substrate for this purpose. To develop the surgical treatment using denuded amniotic membrane as a carrier, we established the tissue engineering system for making transplantable epithelial sheets of either corneal or oral mucosal epithelial cells for ocular surface reconstruction.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1111/j.1525-1594.2004.07319.x</identifier><identifier>PMID: 14720284</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Inc</publisher><subject>Amnion - cytology ; Amniotic membrane ; Animals ; Cells, Cultured ; Cornea - surgery ; Corneal epithelium ; Corneal Injuries ; Epithelial Cells - transplantation ; Epithelium, Corneal - cytology ; Epithelium, Corneal - transplantation ; Feasibility Studies ; Freeze Drying ; Humans ; Mouth Mucosa - cytology ; Ocular surface reconstruction ; Ophthalmologic Surgical Procedures - methods ; Oral mucosal epithelium ; Rabbits ; Regeneration ; Stem cell ; Tissue Engineering - methods</subject><ispartof>Artificial organs, 2004-01, Vol.28 (1), p.22-27</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5009-740ffd596aa74a867090232f5b93d515e27e8eaa3d3bf77739063d4ed9ab42a43</citedby><cites>FETCH-LOGICAL-c5009-740ffd596aa74a867090232f5b93d515e27e8eaa3d3bf77739063d4ed9ab42a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1525-1594.2004.07319.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1525-1594.2004.07319.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14720284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinoshita, Shigeru</creatorcontrib><creatorcontrib>Nakamura, Takahiro</creatorcontrib><title>Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>: Regenerative medicine via tissue engineering is a newly developed medical field based on the use of somatic stem cells to generate biological substitutes and improve tissue functions. The achievement of these objectives depends on two important factors: stem cells, which are high in proliferability and differentiability, and the substrates that support them. In order to reconstruct the ocular surface in patients with severe ocular surface diseases, we decided to investigate the feasibility of human amniotic membrane as an epithelial carrier, and found that denuded amniotic membrane was the most appropriate substrate for this purpose. To develop the surgical treatment using denuded amniotic membrane as a carrier, we established the tissue engineering system for making transplantable epithelial sheets of either corneal or oral mucosal epithelial cells for ocular surface reconstruction.</description><subject>Amnion - cytology</subject><subject>Amniotic membrane</subject><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Cornea - surgery</subject><subject>Corneal epithelium</subject><subject>Corneal Injuries</subject><subject>Epithelial Cells - transplantation</subject><subject>Epithelium, Corneal - cytology</subject><subject>Epithelium, Corneal - transplantation</subject><subject>Feasibility Studies</subject><subject>Freeze Drying</subject><subject>Humans</subject><subject>Mouth Mucosa - cytology</subject><subject>Ocular surface reconstruction</subject><subject>Ophthalmologic Surgical Procedures - methods</subject><subject>Oral mucosal epithelium</subject><subject>Rabbits</subject><subject>Regeneration</subject><subject>Stem cell</subject><subject>Tissue Engineering - methods</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EotvSv4B84pYwju04OXAo23ZBalmpXdTeLG8yUbNk49R2yvbf12FX5Qi-eKT53szoPUIog5TF93mTMpnJhMlSpBmASEFxVqa7N2T22nhLZsBySGQu7o_IsfcbAFAC8vfkiAmVQVaIGanP8Qk7O2yxD9Q2dD52oX0yAWt6PVbWm45eDG14wK6N5e0DYqArZ3o_dKYPJrS2p411dFmNnXH0dnSNqZDeYGV7H9xYTcQH8q4xncfTw39Cfl5erObfkqvl4vv87CqpJECZxOOappZlbowSpsgVlJDxrJHrkteSScwUFmgMr_m6UUrxEnJeC6xLsxaZEfyEfNrPHZx9HNEHvW19hV08Fe3odRG3gCzkP0GmlGRcqggWe7By1nuHjR5cuzXuWTPQUxR6oyfH9eS4nqLQf6LQuyj9eNgxrrdY_xUevI_Alz3wu-3w-b8H67PlzVRFfbLXtz7g7lVv3C-dK66kvvux0PJarRYc7vVX_gJUcKej</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Kinoshita, Shigeru</creator><creator>Nakamura, Takahiro</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction</title><author>Kinoshita, Shigeru ; Nakamura, Takahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5009-740ffd596aa74a867090232f5b93d515e27e8eaa3d3bf77739063d4ed9ab42a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amnion - cytology</topic><topic>Amniotic membrane</topic><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Cornea - surgery</topic><topic>Corneal epithelium</topic><topic>Corneal Injuries</topic><topic>Epithelial Cells - transplantation</topic><topic>Epithelium, Corneal - cytology</topic><topic>Epithelium, Corneal - transplantation</topic><topic>Feasibility Studies</topic><topic>Freeze Drying</topic><topic>Humans</topic><topic>Mouth Mucosa - cytology</topic><topic>Ocular surface reconstruction</topic><topic>Ophthalmologic Surgical Procedures - methods</topic><topic>Oral mucosal epithelium</topic><topic>Rabbits</topic><topic>Regeneration</topic><topic>Stem cell</topic><topic>Tissue Engineering - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinoshita, Shigeru</creatorcontrib><creatorcontrib>Nakamura, Takahiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinoshita, Shigeru</au><au>Nakamura, Takahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2004-01</date><risdate>2004</risdate><volume>28</volume><issue>1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>: Regenerative medicine via tissue engineering is a newly developed medical field based on the use of somatic stem cells to generate biological substitutes and improve tissue functions. The achievement of these objectives depends on two important factors: stem cells, which are high in proliferability and differentiability, and the substrates that support them. In order to reconstruct the ocular surface in patients with severe ocular surface diseases, we decided to investigate the feasibility of human amniotic membrane as an epithelial carrier, and found that denuded amniotic membrane was the most appropriate substrate for this purpose. To develop the surgical treatment using denuded amniotic membrane as a carrier, we established the tissue engineering system for making transplantable epithelial sheets of either corneal or oral mucosal epithelial cells for ocular surface reconstruction.</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>14720284</pmid><doi>10.1111/j.1525-1594.2004.07319.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-564X |
| ispartof | Artificial organs, 2004-01, Vol.28 (1), p.22-27 |
| issn | 0160-564X 1525-1594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80090585 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amnion - cytology Amniotic membrane Animals Cells, Cultured Cornea - surgery Corneal epithelium Corneal Injuries Epithelial Cells - transplantation Epithelium, Corneal - cytology Epithelium, Corneal - transplantation Feasibility Studies Freeze Drying Humans Mouth Mucosa - cytology Ocular surface reconstruction Ophthalmologic Surgical Procedures - methods Oral mucosal epithelium Rabbits Regeneration Stem cell Tissue Engineering - methods |
| title | Development of Cultivated Mucosal Epithelial Sheet Transplantation for Ocular Surface Reconstruction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T13%3A32%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20Cultivated%20Mucosal%20Epithelial%20Sheet%20Transplantation%20for%20Ocular%20Surface%20Reconstruction&rft.jtitle=Artificial%20organs&rft.au=Kinoshita,%20Shigeru&rft.date=2004-01&rft.volume=28&rft.issue=1&rft.spage=22&rft.epage=27&rft.pages=22-27&rft.issn=0160-564X&rft.eissn=1525-1594&rft_id=info:doi/10.1111/j.1525-1594.2004.07319.x&rft_dat=%3Cproquest_cross%3E17751357%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17751357&rft_id=info:pmid/14720284&rfr_iscdi=true |