Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx
Objectives To determine the expression levels of epidermal growth factor receptor (EGFR) and its prognostic value in undifferentiated carcinoma (UC) of the nasopharynx. Study Design A prospective study of 75 patients diagnosed with UC over a 4‐year period in a tertiary care hospital. Materials and M...
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| Veröffentlicht in: | The Laryngoscope 2004-01, Vol.114 (1), p.153-157 |
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| creator | Leong, Jern-Lin Loh, Kwok Seng Putti, Thomas Choudhary Goh, Boon Cher Tan, Luke Kim Siang |
| description | Objectives To determine the expression levels of epidermal growth factor receptor (EGFR) and its prognostic value in undifferentiated carcinoma (UC) of the nasopharynx.
Study Design A prospective study of 75 patients diagnosed with UC over a 4‐year period in a tertiary care hospital.
Materials and Methods Postnasal space biopsies were obtained and processed, and immunohistochemical staining was performed. The over‐expression of EGFR was measured, and the expression levels were statistically analyzed with the clinical and pathologic variables. Disease‐free and overall survival analyses were performed.
Results There were 62 (82.7%) specimens that showed over‐expression of EGFR levels. Over‐expression of EGFR correlated significantly only with primary tumor size (P = .007). Age, sex, positive smoking and family history, presence of nodal metastasis, distant metastasis, and Epstein‐Barr virus serology titers were not significantly correlated with over‐expression of EGFR. Both 54‐month disease‐free and 56‐month overall survivals were not associated with EGFR over‐expression.
Conclusion The frequency of over‐expression of EGFR in UC is similar to other squamous cell carcinoma (SCC) of the head and neck region. Only primary tumor size is independently correlated with over‐expression of EGFR. EGFR over‐expression does not affect disease‐free and overall survival. |
| doi_str_mv | 10.1097/00005537-200401000-00029 |
| format | Article |
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Study Design A prospective study of 75 patients diagnosed with UC over a 4‐year period in a tertiary care hospital.
Materials and Methods Postnasal space biopsies were obtained and processed, and immunohistochemical staining was performed. The over‐expression of EGFR was measured, and the expression levels were statistically analyzed with the clinical and pathologic variables. Disease‐free and overall survival analyses were performed.
Results There were 62 (82.7%) specimens that showed over‐expression of EGFR levels. Over‐expression of EGFR correlated significantly only with primary tumor size (P = .007). Age, sex, positive smoking and family history, presence of nodal metastasis, distant metastasis, and Epstein‐Barr virus serology titers were not significantly correlated with over‐expression of EGFR. Both 54‐month disease‐free and 56‐month overall survivals were not associated with EGFR over‐expression.
Conclusion The frequency of over‐expression of EGFR in UC is similar to other squamous cell carcinoma (SCC) of the head and neck region. Only primary tumor size is independently correlated with over‐expression of EGFR. EGFR over‐expression does not affect disease‐free and overall survival.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/00005537-200401000-00029</identifier><identifier>PMID: 14710013</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Carcinoma - metabolism ; Carcinoma - mortality ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - mortality ; Otorhinolaryngology. Stomatology ; Prognosis ; prognostic factors ; Prospective Studies ; Receptor, Epidermal Growth Factor - metabolism ; Survival Analysis</subject><ispartof>The Laryngoscope, 2004-01, Vol.114 (1), p.153-157</ispartof><rights>Copyright © 2004 The Triological Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5069-e69674b39bdb402392fffa036783bb994cb76a5066ab86be2911e40f0e8acafd3</citedby><cites>FETCH-LOGICAL-c5069-e69674b39bdb402392fffa036783bb994cb76a5066ab86be2911e40f0e8acafd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F00005537-200401000-00029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F00005537-200401000-00029$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15432313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14710013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leong, Jern-Lin</creatorcontrib><creatorcontrib>Loh, Kwok Seng</creatorcontrib><creatorcontrib>Putti, Thomas Choudhary</creatorcontrib><creatorcontrib>Goh, Boon Cher</creatorcontrib><creatorcontrib>Tan, Luke Kim Siang</creatorcontrib><title>Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives To determine the expression levels of epidermal growth factor receptor (EGFR) and its prognostic value in undifferentiated carcinoma (UC) of the nasopharynx.
Study Design A prospective study of 75 patients diagnosed with UC over a 4‐year period in a tertiary care hospital.
Materials and Methods Postnasal space biopsies were obtained and processed, and immunohistochemical staining was performed. The over‐expression of EGFR was measured, and the expression levels were statistically analyzed with the clinical and pathologic variables. Disease‐free and overall survival analyses were performed.
Results There were 62 (82.7%) specimens that showed over‐expression of EGFR levels. Over‐expression of EGFR correlated significantly only with primary tumor size (P = .007). Age, sex, positive smoking and family history, presence of nodal metastasis, distant metastasis, and Epstein‐Barr virus serology titers were not significantly correlated with over‐expression of EGFR. Both 54‐month disease‐free and 56‐month overall survivals were not associated with EGFR over‐expression.
Conclusion The frequency of over‐expression of EGFR in UC is similar to other squamous cell carcinoma (SCC) of the head and neck region. Only primary tumor size is independently correlated with over‐expression of EGFR. EGFR over‐expression does not affect disease‐free and overall survival.</description><subject>Biological and medical sciences</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - mortality</subject><subject>Cohort Studies</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - metabolism</subject><subject>Nasopharyngeal Neoplasms - mortality</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>Prospective Studies</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Survival Analysis</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1vFCEYhYnR2G31Lxhu9G4qDDAMl3VttybrNt3YVK8IMC9ZdL6E2bT996W7a3srCQHePOdwchDClJxSouRnkpcQTBYlIZzQ_CryLtUrNKOC0YIrJV6jWR6xohblzyN0nNJvQqhkgrxFR5TLLKJshq7Px9BA7EyLF3G4mzb4wrhpiHgNDsanS-jxTd8E7yFCPwUzQYPnJrrQD53Bg8fTBvDKpGHcmPjQ379Db7xpE7w_nCfo5uL8x_yyWF4tvs3PloUTpFIFVKqS3DJlG8tzTlV67w1hlayZtUpxZ2VlMloZW1cWSkUpcOIJ1MYZ37AT9GnvO8bh7xbSpLuQHLSt6WHYJl0ToojgPIP1HnRxSCmC12MMXc6qKdFPdep_dernOvWuziz9cPhjaztoXoSH_jLw8QCY5Ezro-ldSC-c4KxkO-7rnrsLLTz8dwC9PFv_EoJTmqe7PMXeJqQJ7p9tTPyjK8mk0LerhV7Vt_wL_77WK_YIBPqerg</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Leong, Jern-Lin</creator><creator>Loh, Kwok Seng</creator><creator>Putti, Thomas Choudhary</creator><creator>Goh, Boon Cher</creator><creator>Tan, Luke Kim Siang</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200401</creationdate><title>Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx</title><author>Leong, Jern-Lin ; Loh, Kwok Seng ; Putti, Thomas Choudhary ; Goh, Boon Cher ; Tan, Luke Kim Siang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5069-e69674b39bdb402392fffa036783bb994cb76a5066ab86be2911e40f0e8acafd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - mortality</topic><topic>Cohort Studies</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - metabolism</topic><topic>Nasopharyngeal Neoplasms - mortality</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>Prospective Studies</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leong, Jern-Lin</creatorcontrib><creatorcontrib>Loh, Kwok Seng</creatorcontrib><creatorcontrib>Putti, Thomas Choudhary</creatorcontrib><creatorcontrib>Goh, Boon Cher</creatorcontrib><creatorcontrib>Tan, Luke Kim Siang</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leong, Jern-Lin</au><au>Loh, Kwok Seng</au><au>Putti, Thomas Choudhary</au><au>Goh, Boon Cher</au><au>Tan, Luke Kim Siang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2004-01</date><risdate>2004</risdate><volume>114</volume><issue>1</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives To determine the expression levels of epidermal growth factor receptor (EGFR) and its prognostic value in undifferentiated carcinoma (UC) of the nasopharynx.
Study Design A prospective study of 75 patients diagnosed with UC over a 4‐year period in a tertiary care hospital.
Materials and Methods Postnasal space biopsies were obtained and processed, and immunohistochemical staining was performed. The over‐expression of EGFR was measured, and the expression levels were statistically analyzed with the clinical and pathologic variables. Disease‐free and overall survival analyses were performed.
Results There were 62 (82.7%) specimens that showed over‐expression of EGFR levels. Over‐expression of EGFR correlated significantly only with primary tumor size (P = .007). Age, sex, positive smoking and family history, presence of nodal metastasis, distant metastasis, and Epstein‐Barr virus serology titers were not significantly correlated with over‐expression of EGFR. Both 54‐month disease‐free and 56‐month overall survivals were not associated with EGFR over‐expression.
Conclusion The frequency of over‐expression of EGFR in UC is similar to other squamous cell carcinoma (SCC) of the head and neck region. Only primary tumor size is independently correlated with over‐expression of EGFR. EGFR over‐expression does not affect disease‐free and overall survival.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>14710013</pmid><doi>10.1097/00005537-200401000-00029</doi><tpages>5</tpages></addata></record> |
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| source | Wiley-Blackwell Journals; Journals@Ovid Complete - AutoHoldings; MEDLINE |
| subjects | Biological and medical sciences Carcinoma - metabolism Carcinoma - mortality Cohort Studies Disease-Free Survival Female Humans Immunohistochemistry Male Medical sciences Middle Aged nasopharyngeal carcinoma Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - mortality Otorhinolaryngology. Stomatology Prognosis prognostic factors Prospective Studies Receptor, Epidermal Growth Factor - metabolism Survival Analysis |
| title | Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx |
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