Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995
National Institute for Communicable Diseases and Department of Medical Virology, University of Witwatersrand, Private Bag X4, Sandringham 2131, South Africa Correspondence Hazel Maila hazelm{at}nicd.ac.za Endemic circulation of hepatitis E virus (HEV) in Namibia was suspected from serological data d...
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| Veröffentlicht in: | Journal of general virology 2004-01, Vol.85 (1), p.89-95 |
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| creator | Maila, Hazel T Bowyer, Sheila M Swanepoel, Robert |
| description | National Institute for Communicable Diseases and Department of Medical Virology, University of Witwatersrand, Private Bag X4, Sandringham 2131, South Africa
Correspondence Hazel Maila hazelm{at}nicd.ac.za
Endemic circulation of hepatitis E virus (HEV) in Namibia was suspected from serological data during an outbreak of non-A, non-B hepatitis in Rundu in 1995. The source of the outbreak was suspected to be the water supply, which had been compromised approximately 6 months earlier. Four HEV isolates from four different persons in this outbreak were successfully amplified, sequenced and analysed over a 451 bp region of a subgenomic fragment from the 3' end of the genome in ORF2. Phylogenetic analysis showed that the four Namibian HEV isolates clustered with a Mexican isolate in genotype II and shared 85·886·3 % nucleotide identity with the 1987 Mexican isolate, but were only 77·679·6 % similar to other African isolates. HEV isolated from the same region of Namibia in 1983 was reported to cluster in genotype I. However, virus isolates from sporadic cases of HEV isolated in 1997/8 in Nigeria were also from genotype II. |
| doi_str_mv | 10.1099/vir.0.19587-0 |
| format | Article |
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Correspondence Hazel Maila hazelm{at}nicd.ac.za
Endemic circulation of hepatitis E virus (HEV) in Namibia was suspected from serological data during an outbreak of non-A, non-B hepatitis in Rundu in 1995. The source of the outbreak was suspected to be the water supply, which had been compromised approximately 6 months earlier. Four HEV isolates from four different persons in this outbreak were successfully amplified, sequenced and analysed over a 451 bp region of a subgenomic fragment from the 3' end of the genome in ORF2. Phylogenetic analysis showed that the four Namibian HEV isolates clustered with a Mexican isolate in genotype II and shared 85·886·3 % nucleotide identity with the 1987 Mexican isolate, but were only 77·679·6 % similar to other African isolates. HEV isolated from the same region of Namibia in 1983 was reported to cluster in genotype I. However, virus isolates from sporadic cases of HEV isolated in 1997/8 in Nigeria were also from genotype II.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/vir.0.19587-0</identifier><identifier>PMID: 14718623</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>3' Untranslated Regions - genetics ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; Biological and medical sciences ; Child ; Consensus Sequence ; Disease Outbreaks ; Female ; Fundamental and applied biological sciences. Psychology ; Hepatitis Antibodies - blood ; Hepatitis E - epidemiology ; Hepatitis E - virology ; Hepatitis E virus ; Hepatitis E virus - classification ; Hepatitis E virus - genetics ; Hepatitis E virus - isolation & purification ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Sequence Data ; Namibia - epidemiology ; Open Reading Frames - genetics ; Phylogeny ; Sequence Analysis, DNA ; Viral diseases ; Viral hepatitis ; Virology</subject><ispartof>Journal of general virology, 2004-01, Vol.85 (1), p.89-95</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-404c53464002fe48a7b4d6a3da69503bfa058fd4b0aefd30a15307f01ef085d3</citedby><cites>FETCH-LOGICAL-c420t-404c53464002fe48a7b4d6a3da69503bfa058fd4b0aefd30a15307f01ef085d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3733,3734,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15488825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14718623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maila, Hazel T</creatorcontrib><creatorcontrib>Bowyer, Sheila M</creatorcontrib><creatorcontrib>Swanepoel, Robert</creatorcontrib><title>Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>National Institute for Communicable Diseases and Department of Medical Virology, University of Witwatersrand, Private Bag X4, Sandringham 2131, South Africa
Correspondence Hazel Maila hazelm{at}nicd.ac.za
Endemic circulation of hepatitis E virus (HEV) in Namibia was suspected from serological data during an outbreak of non-A, non-B hepatitis in Rundu in 1995. The source of the outbreak was suspected to be the water supply, which had been compromised approximately 6 months earlier. Four HEV isolates from four different persons in this outbreak were successfully amplified, sequenced and analysed over a 451 bp region of a subgenomic fragment from the 3' end of the genome in ORF2. Phylogenetic analysis showed that the four Namibian HEV isolates clustered with a Mexican isolate in genotype II and shared 85·886·3 % nucleotide identity with the 1987 Mexican isolate, but were only 77·679·6 % similar to other African isolates. HEV isolated from the same region of Namibia in 1983 was reported to cluster in genotype I. However, virus isolates from sporadic cases of HEV isolated in 1997/8 in Nigeria were also from genotype II.</description><subject>3' Untranslated Regions - genetics</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Consensus Sequence</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis E - epidemiology</subject><subject>Hepatitis E - virology</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - classification</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Namibia - epidemiology</subject><subject>Open Reading Frames - genetics</subject><subject>Phylogeny</subject><subject>Sequence Analysis, DNA</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virology</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EglIYWZEX2ALn2E7sESG-JARLJUbrktjU0CTFTkD89zhQqSOTn_V-unv3CDlhcMFA68tPHy6S1FKVGeyQGROFzPLk7JIZQJ5njLPygBzG-AbAhJDlPjlgomSqyPmMvDw0thu88zUOvu9o7yjSzn7ROAT0v_-lXSdv8JHe0LRtjNSFvqWYzHGogsV3msAnbH3lcZJMa3lE9hyuoj3evHOyuL1ZXN9nj893D9dXj1ktchgyAaKWXBQiRXVWKCwr0RTIGyy0BF45BKlcIypA6xoOyCSH0gGzDpRs-Jyc_41dh_5jtHEwrY-1Xa2ws_0YjQLQkO7-F2Q6L5guIYHZH1iHPsZgnVkH32L4NgzM1LhJHZgkp8bNxJ9uBo9Va5stvak4AWcbAGONKxewq33cclIopXK5Tbj0r8svH6x5tV3rU4zK99NSJQ0zSvMfmI-VaQ</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Maila, Hazel T</creator><creator>Bowyer, Sheila M</creator><creator>Swanepoel, Robert</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995</title><author>Maila, Hazel T ; Bowyer, Sheila M ; Swanepoel, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-404c53464002fe48a7b4d6a3da69503bfa058fd4b0aefd30a15307f01ef085d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Consensus Sequence</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis E - epidemiology</topic><topic>Hepatitis E - virology</topic><topic>Hepatitis E virus</topic><topic>Hepatitis E virus - classification</topic><topic>Hepatitis E virus - genetics</topic><topic>Hepatitis E virus - isolation & purification</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Namibia - epidemiology</topic><topic>Open Reading Frames - genetics</topic><topic>Phylogeny</topic><topic>Sequence Analysis, DNA</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maila, Hazel T</creatorcontrib><creatorcontrib>Bowyer, Sheila M</creatorcontrib><creatorcontrib>Swanepoel, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maila, Hazel T</au><au>Bowyer, Sheila M</au><au>Swanepoel, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>85</volume><issue>1</issue><spage>89</spage><epage>95</epage><pages>89-95</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>National Institute for Communicable Diseases and Department of Medical Virology, University of Witwatersrand, Private Bag X4, Sandringham 2131, South Africa
Correspondence Hazel Maila hazelm{at}nicd.ac.za
Endemic circulation of hepatitis E virus (HEV) in Namibia was suspected from serological data during an outbreak of non-A, non-B hepatitis in Rundu in 1995. The source of the outbreak was suspected to be the water supply, which had been compromised approximately 6 months earlier. Four HEV isolates from four different persons in this outbreak were successfully amplified, sequenced and analysed over a 451 bp region of a subgenomic fragment from the 3' end of the genome in ORF2. Phylogenetic analysis showed that the four Namibian HEV isolates clustered with a Mexican isolate in genotype II and shared 85·886·3 % nucleotide identity with the 1987 Mexican isolate, but were only 77·679·6 % similar to other African isolates. HEV isolated from the same region of Namibia in 1983 was reported to cluster in genotype I. However, virus isolates from sporadic cases of HEV isolated in 1997/8 in Nigeria were also from genotype II.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>14718623</pmid><doi>10.1099/vir.0.19587-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated Regions - genetics Adolescent Adult Aged Aged, 80 and over Amino Acid Sequence Biological and medical sciences Child Consensus Sequence Disease Outbreaks Female Fundamental and applied biological sciences. Psychology Hepatitis Antibodies - blood Hepatitis E - epidemiology Hepatitis E - virology Hepatitis E virus Hepatitis E virus - classification Hepatitis E virus - genetics Hepatitis E virus - isolation & purification Human viral diseases Humans Infant Infant, Newborn Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Sequence Data Namibia - epidemiology Open Reading Frames - genetics Phylogeny Sequence Analysis, DNA Viral diseases Viral hepatitis Virology |
| title | Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995 |
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