Gene delivery to cartilage defects using coagulated bone marrow aspirate

The long-term goal of the present study is to develop a clinically applicable approach to enhance natural repair mechanisms within cartilage lesions by targeting bone marrow-derived cells for genetic modification. To determine if bone marrow-derived cells infiltrating osteochondral defects could be...

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Veröffentlicht in:	Gene therapy 2004-01, Vol.11 (2), p.133-141
Hauptverfasser:	Pascher, A, Palmer, GD, Steinert, A, Oligino, T, Gouze, E, Gouze, J-N, Betz, O, Spector, M, Robbins, PD, Evans, CH, Ghivizzani, SC
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Arthritis Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Bone Marrow Transplantation Care and treatment Cartilage Diseases - pathology Cartilage Diseases - therapy Cell Biology Diseases of the osteoarticular system Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage glycosaminoglycans Health aspects Health. Pharmaceutical industry Human Genetics Industrial applications and implications. Economical aspects Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Models, Animal Nanotechnology Rabbits research-article Stem Cell Transplantation Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Transplantation, Autologous
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