Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells

We have generated a molecular description of the loci at which stability/instability of expression of a monoclonal antibody (MAb) (anti‐CD38) occurs within the GS‐NS0 expression system. Critically, these data show that, in the absence of changes to copy number for the recombinant gene sequences, all...

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Veröffentlicht in:	Biotechnology and bioengineering 2004-01, Vol.85 (2), p.115-121
Hauptverfasser:	Barnes, Louise M., Bentley, Catherine M., Dickson, Alan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - genetics ADP-ribosyl Cyclase - metabolism ADP-ribosyl Cyclase 1 Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - genetics Antigens, CD - genetics Antigens, CD - metabolism Biomarkers - analysis Cell Line, Tumor copy number Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Genetic Variation - genetics GS-NS0 Membrane Glycoproteins Mice mRNA analysis Myeloma Proteins - genetics Myeloma Proteins - metabolism predictive indicator of instability productivity Protein Engineering - methods recombinant antibody Recombinant Proteins - biosynthesis
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