A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation
Epinephrine is recommended for use in the resuscitation of patients with cardiac arrest. In this clinical trial, vasopressin, as compared with epinephrine, improved the rates of survival to hospital admission and discharge, but only among patients with asystolic cardiac arrest. There was no advantag...
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| Veröffentlicht in: | The New England journal of medicine 2004-01, Vol.350 (2), p.105-113 |
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| creator | Wenzel, Volker Krismer, Anette C Arntz, H. Richard Sitter, Helmut Stadlbauer, Karl H Lindner, Karl H |
| description | Epinephrine is recommended for use in the resuscitation of patients with cardiac arrest. In this clinical trial, vasopressin, as compared with epinephrine, improved the rates of survival to hospital admission and discharge, but only among patients with asystolic cardiac arrest. There was no advantage to vasopressin therapy in patients with ventricular fibrillation or pulseless electrical activity.
As compared with epinephrine, improved the rates of survival to hospital admission.
There are more than 600,000 sudden deaths in North America and Europe each year. More than half of these deaths occur before 65 years of age, which underscores the need for optimal cardiopulmonary resuscitation (CPR) strategies in order to improve patients' chances of survival.
Epinephrine has been used during CPR for more than 100 years
1
but has become controversial because it is associated with increased myocardial oxygen consumption, ventricular arrhythmias, and myocardial dysfunction during the period after resuscitation.
2
Since it was found that endogenous vasopressin levels in successfully resuscitated patients were significantly higher than levels in patients who died, it . . . |
| doi_str_mv | 10.1056/NEJMoa025431 |
| format | Article |
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As compared with epinephrine, improved the rates of survival to hospital admission.
There are more than 600,000 sudden deaths in North America and Europe each year. More than half of these deaths occur before 65 years of age, which underscores the need for optimal cardiopulmonary resuscitation (CPR) strategies in order to improve patients' chances of survival.
Epinephrine has been used during CPR for more than 100 years
1
but has become controversial because it is associated with increased myocardial oxygen consumption, ventricular arrhythmias, and myocardial dysfunction during the period after resuscitation.
2
Since it was found that endogenous vasopressin levels in successfully resuscitated patients were significantly higher than levels in patients who died, it . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa025431</identifier><identifier>PMID: 14711909</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiopulmonary Resuscitation ; Clinical trials ; CPR ; Drug therapy ; Drug Therapy, Combination ; Drugs ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emergency Medical Services ; Epinephrine - therapeutic use ; Female ; Heart Arrest - drug therapy ; Heart Arrest - mortality ; Heart attacks ; Hospitalization ; Humans ; Intensive care medicine ; Male ; Medical procedures ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Survival Rate ; Sympathomimetics - therapeutic use ; Vasoconstrictor Agents - therapeutic use ; Vasopressins - therapeutic use ; Ventricular Fibrillation - drug therapy</subject><ispartof>The New England journal of medicine, 2004-01, Vol.350 (2), p.105-113</ispartof><rights>Copyright © 2004 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-f5b3be0a9141ea29a3ae2139cd888acaa2ec2bc94e668477699db6347f6603533</citedby><cites>FETCH-LOGICAL-c564t-f5b3be0a9141ea29a3ae2139cd888acaa2ec2bc94e668477699db6347f6603533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa025431$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa025431$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15409335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14711909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wenzel, Volker</creatorcontrib><creatorcontrib>Krismer, Anette C</creatorcontrib><creatorcontrib>Arntz, H. Richard</creatorcontrib><creatorcontrib>Sitter, Helmut</creatorcontrib><creatorcontrib>Stadlbauer, Karl H</creatorcontrib><creatorcontrib>Lindner, Karl H</creatorcontrib><creatorcontrib>European Resuscitation Council Vasopressor during Cardiopulmonary Resuscitation Study Group</creatorcontrib><title>A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Epinephrine is recommended for use in the resuscitation of patients with cardiac arrest. In this clinical trial, vasopressin, as compared with epinephrine, improved the rates of survival to hospital admission and discharge, but only among patients with asystolic cardiac arrest. There was no advantage to vasopressin therapy in patients with ventricular fibrillation or pulseless electrical activity.
As compared with epinephrine, improved the rates of survival to hospital admission.
There are more than 600,000 sudden deaths in North America and Europe each year. More than half of these deaths occur before 65 years of age, which underscores the need for optimal cardiopulmonary resuscitation (CPR) strategies in order to improve patients' chances of survival.
Epinephrine has been used during CPR for more than 100 years
1
but has become controversial because it is associated with increased myocardial oxygen consumption, ventricular arrhythmias, and myocardial dysfunction during the period after resuscitation.
2
Since it was found that endogenous vasopressin levels in successfully resuscitated patients were significantly higher than levels in patients who died, it . . .</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary Resuscitation</subject><subject>Clinical trials</subject><subject>CPR</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Drugs</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emergency Medical Services</subject><subject>Epinephrine - therapeutic use</subject><subject>Female</subject><subject>Heart Arrest - drug therapy</subject><subject>Heart Arrest - mortality</subject><subject>Heart attacks</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical procedures</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Survival Rate</subject><subject>Sympathomimetics - therapeutic use</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><subject>Vasopressins - therapeutic use</subject><subject>Ventricular Fibrillation - drug therapy</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0Etr3DAUBWBRUprJtLusgwhJV3UjWbJsLYdh8iJpILTdFXMty0SDLTm69qL_PiozkBKihbTQx5XOIeSYs--cFerix-b2PgDLCyn4B7LghRCZlEwdkAVjeZXJUotDcoS4ZWlxqT-RQy5LzjXTC_JnRddhGCE6DJ6Gjv4GDGO0iM5T8C3djM7b8SmmnXYh0od5ykKXXQcc3QQ9XUNsXRjnfgge4l_6aHFGk64mF_xn8rGDHu2X_bkkvy43P9fX2d3D1c16dZeZQskp64pGNJaB5pJbyDUIsDkX2rRVVYEByK3JG6OlVaqSZam0bhslZNkpxUQKvCRfd3PHGJ5ni1M9ODS278HbMGNdMVaVsuIJnr6B2zBHn_5W57nQslRKJ_Rth0wMiNF29RjdkMLVnNX_Oq__7zzxk_3MuRls-4r3JSdwvgeABvougjcOX10hE0oxluRs54YBa2-3w_vvvQBqLZSW</recordid><startdate>20040108</startdate><enddate>20040108</enddate><creator>Wenzel, Volker</creator><creator>Krismer, Anette C</creator><creator>Arntz, H. 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Richard</au><au>Sitter, Helmut</au><au>Stadlbauer, Karl H</au><au>Lindner, Karl H</au><aucorp>European Resuscitation Council Vasopressor during Cardiopulmonary Resuscitation Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2004-01-08</date><risdate>2004</risdate><volume>350</volume><issue>2</issue><spage>105</spage><epage>113</epage><pages>105-113</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Epinephrine is recommended for use in the resuscitation of patients with cardiac arrest. In this clinical trial, vasopressin, as compared with epinephrine, improved the rates of survival to hospital admission and discharge, but only among patients with asystolic cardiac arrest. There was no advantage to vasopressin therapy in patients with ventricular fibrillation or pulseless electrical activity.
As compared with epinephrine, improved the rates of survival to hospital admission.
There are more than 600,000 sudden deaths in North America and Europe each year. More than half of these deaths occur before 65 years of age, which underscores the need for optimal cardiopulmonary resuscitation (CPR) strategies in order to improve patients' chances of survival.
Epinephrine has been used during CPR for more than 100 years
1
but has become controversial because it is associated with increased myocardial oxygen consumption, ventricular arrhythmias, and myocardial dysfunction during the period after resuscitation.
2
Since it was found that endogenous vasopressin levels in successfully resuscitated patients were significantly higher than levels in patients who died, it . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>14711909</pmid><doi>10.1056/NEJMoa025431</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2004-01, Vol.350 (2), p.105-113 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiopulmonary Resuscitation Clinical trials CPR Drug therapy Drug Therapy, Combination Drugs Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emergency Medical Services Epinephrine - therapeutic use Female Heart Arrest - drug therapy Heart Arrest - mortality Heart attacks Hospitalization Humans Intensive care medicine Male Medical procedures Medical sciences Middle Aged Multivariate Analysis Survival Rate Sympathomimetics - therapeutic use Vasoconstrictor Agents - therapeutic use Vasopressins - therapeutic use Ventricular Fibrillation - drug therapy |
| title | A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation |
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