Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

PDZ-RhoGEF, LARG, and p115RhoGEF are members of a newly identified family of Rho-guanine nucleotide exchange factors (GEFs) exhibiting a unique structural feature consisting of the presence of an area of similarity to regulators of G protein signaling (RGS). This RGS-like (RGL) domain provides a fun...

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Veröffentlicht in:	Oncogene 2004-01, Vol.23 (1), p.233-240
Hauptverfasser:	Chikumi, Hiroki, Barac, Ana, Behbahani, Babak, Gao, Yuan, Teramoto, Hidemi, Zheng, Yi, Gutkind, J Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cell Biology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Fundamental and applied biological sciences. Psychology Gene expression Growth factors guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - physiology Human Genetics Humans Internal Medicine Kinases LARG protein Medicine Medicine & Public Health Mice Molecular and cellular biology NIH 3T3 Cells Oncology original-paper PDZ-RhoGEF protein Phosphorylation Proteins Receptors, Glutamate - chemistry Receptors, Glutamate - physiology Rho Guanine Nucleotide Exchange Factors Structure-Activity Relationship Throat cancer
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