Multiresistant Salmonella typhimurium systemic infection in Rwanda. Clinical features and treatment with cefotaxime
Children with multiresistant Salmonella typhimurium (MRST) systemic infections, in total 246, were diagnosed during the study period. Of these, 220 had MRST without metastatic focal infections and 26 had metastatic focal infections (including 12 patients with meningitis). The median age of the child...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1990-09, Vol.26 (suppl-A), p.53-57 |
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| container_issue | suppl-A |
| container_start_page | 53 |
| container_title | Journal of antimicrobial chemotherapy |
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| creator | Lepage, Philippe Bogaerts, Jos Van Goethem, Christiaan Hitimana, Deo Gratias Nsengumuremyi, François |
| description | Children with multiresistant Salmonella typhimurium (MRST) systemic infections, in total 246, were diagnosed during the study period. Of these, 220 had MRST without metastatic focal infections and 26 had metastatic focal infections (including 12 patients with meningitis). The median age of the children was 10 months. Diarrhoeal disease, measles and severe malnutrition were the most frequent causes of admission. Fever was found in 99% and diarrhoea in 72% of the patients, with respiratory symptoms in 72%. In 199 (81%) of the patients, the MRST infection was considered to be hospital-acquired. Of the 246 children, 159 were treated with cefotaxime. In this group, 16 of 152 patients died (10.5%). However, of the 87 children who did not receive cefotaxime, 64 died (74%). Relapses occurred in 4% of the patients with bacteraemia treated with cefotaxime. Our study confirms the high efficiency of cefotaxime in treating severe systemic infections with MRST. |
| doi_str_mv | 10.1093/jac/26.suppl_A.53 |
| format | Article |
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Clinical features and treatment with cefotaxime</title><source>Oxford University Press Journals Digital Archive legacy</source><source>MEDLINE</source><creator>Lepage, Philippe ; Bogaerts, Jos ; Van Goethem, Christiaan ; Hitimana, Deo Gratias ; Nsengumuremyi, François</creator><creatorcontrib>Lepage, Philippe ; Bogaerts, Jos ; Van Goethem, Christiaan ; Hitimana, Deo Gratias ; Nsengumuremyi, François</creatorcontrib><description>Children with multiresistant Salmonella typhimurium (MRST) systemic infections, in total 246, were diagnosed during the study period. Of these, 220 had MRST without metastatic focal infections and 26 had metastatic focal infections (including 12 patients with meningitis). The median age of the children was 10 months. Diarrhoeal disease, measles and severe malnutrition were the most frequent causes of admission. Fever was found in 99% and diarrhoea in 72% of the patients, with respiratory symptoms in 72%. In 199 (81%) of the patients, the MRST infection was considered to be hospital-acquired. Of the 246 children, 159 were treated with cefotaxime. In this group, 16 of 152 patients died (10.5%). However, of the 87 children who did not receive cefotaxime, 64 died (74%). Relapses occurred in 4% of the patients with bacteraemia treated with cefotaxime. Our study confirms the high efficiency of cefotaxime in treating severe systemic infections with MRST.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/26.suppl_A.53</identifier><identifier>PMID: 2228845</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cefotaxime - therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Microbial ; Humans ; Infant ; Infant, Newborn ; Medical sciences ; Pharmacology. Drug treatments ; Rwanda ; Salmonella Infections - drug therapy ; Salmonella typhimurium - drug effects</subject><ispartof>Journal of antimicrobial chemotherapy, 1990-09, Vol.26 (suppl-A), p.53-57</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-c7231deb7043d574ee973d86899b11adec74a22cad633597e3bdbb48dfa839f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19341084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2228845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lepage, Philippe</creatorcontrib><creatorcontrib>Bogaerts, Jos</creatorcontrib><creatorcontrib>Van Goethem, Christiaan</creatorcontrib><creatorcontrib>Hitimana, Deo Gratias</creatorcontrib><creatorcontrib>Nsengumuremyi, François</creatorcontrib><title>Multiresistant Salmonella typhimurium systemic infection in Rwanda. Clinical features and treatment with cefotaxime</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Children with multiresistant Salmonella typhimurium (MRST) systemic infections, in total 246, were diagnosed during the study period. Of these, 220 had MRST without metastatic focal infections and 26 had metastatic focal infections (including 12 patients with meningitis). The median age of the children was 10 months. Diarrhoeal disease, measles and severe malnutrition were the most frequent causes of admission. Fever was found in 99% and diarrhoea in 72% of the patients, with respiratory symptoms in 72%. In 199 (81%) of the patients, the MRST infection was considered to be hospital-acquired. Of the 246 children, 159 were treated with cefotaxime. In this group, 16 of 152 patients died (10.5%). However, of the 87 children who did not receive cefotaxime, 64 died (74%). Relapses occurred in 4% of the patients with bacteraemia treated with cefotaxime. Our study confirms the high efficiency of cefotaxime in treating severe systemic infections with MRST.</description><subject>Adolescent</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cefotaxime - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Microbial</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rwanda</subject><subject>Salmonella Infections - drug therapy</subject><subject>Salmonella typhimurium - drug effects</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtrFTEYhoNY6rH1B7gQstHdnOY-ybIcqhVbRasobkIm8w1NnZtJhvb8e1POUFe5vO_3QJ4g9JqSLSWGn905f8bUNi3z3NvzreTP0IYKRSpGDH2ONoQTWdVC8hfoZUp3hBAllT5Gx4wxrYXcoHS99DlESCFlN2Z84_phGqHvHc77-TYMSwzLgNM-ZRiCx2HswOcwjWWHv927sXVbvOvDGLzrcQcuLwWGyz3OsZwGKND7kG-xh27K7iEMcIqOOtcneLWuJ-jH-4vvu8vq6suHj7vzq8pzJXLla8ZpC01NBG9lLQBMzVuttDENpa4FXwvHmHet4lyaGnjTNo3Qbec0N53hJ-jdgTvH6e8CKdshJP_4thGmJVlNSKExWYr0UPRxSilCZ-cYBhf3lhL7KNoW0ZYpu4q2kpeZNyt8aQZonyZWsyV_u-YuFTVddKMP6T_YcEGJFqVXHXrlA-DhKXfxj1U1r6W9_PXbfvr803xlO2YN_wfrKZuF</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Lepage, Philippe</creator><creator>Bogaerts, Jos</creator><creator>Van Goethem, Christiaan</creator><creator>Hitimana, Deo Gratias</creator><creator>Nsengumuremyi, François</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Multiresistant Salmonella typhimurium systemic infection in Rwanda. Clinical features and treatment with cefotaxime</title><author>Lepage, Philippe ; Bogaerts, Jos ; Van Goethem, Christiaan ; Hitimana, Deo Gratias ; Nsengumuremyi, François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-c7231deb7043d574ee973d86899b11adec74a22cad633597e3bdbb48dfa839f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cefotaxime - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Microbial</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rwanda</topic><topic>Salmonella Infections - drug therapy</topic><topic>Salmonella typhimurium - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lepage, Philippe</creatorcontrib><creatorcontrib>Bogaerts, Jos</creatorcontrib><creatorcontrib>Van Goethem, Christiaan</creatorcontrib><creatorcontrib>Hitimana, Deo Gratias</creatorcontrib><creatorcontrib>Nsengumuremyi, François</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lepage, Philippe</au><au>Bogaerts, Jos</au><au>Van Goethem, Christiaan</au><au>Hitimana, Deo Gratias</au><au>Nsengumuremyi, François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiresistant Salmonella typhimurium systemic infection in Rwanda. Clinical features and treatment with cefotaxime</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>26</volume><issue>suppl-A</issue><spage>53</spage><epage>57</epage><pages>53-57</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Children with multiresistant Salmonella typhimurium (MRST) systemic infections, in total 246, were diagnosed during the study period. Of these, 220 had MRST without metastatic focal infections and 26 had metastatic focal infections (including 12 patients with meningitis). The median age of the children was 10 months. Diarrhoeal disease, measles and severe malnutrition were the most frequent causes of admission. Fever was found in 99% and diarrhoea in 72% of the patients, with respiratory symptoms in 72%. In 199 (81%) of the patients, the MRST infection was considered to be hospital-acquired. Of the 246 children, 159 were treated with cefotaxime. In this group, 16 of 152 patients died (10.5%). However, of the 87 children who did not receive cefotaxime, 64 died (74%). Relapses occurred in 4% of the patients with bacteraemia treated with cefotaxime. Our study confirms the high efficiency of cefotaxime in treating severe systemic infections with MRST.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2228845</pmid><doi>10.1093/jac/26.suppl_A.53</doi><tpages>5</tpages></addata></record> |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adolescent Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - therapeutic use Child Child, Preschool Drug Resistance, Microbial Humans Infant Infant, Newborn Medical sciences Pharmacology. Drug treatments Rwanda Salmonella Infections - drug therapy Salmonella typhimurium - drug effects |
| title | Multiresistant Salmonella typhimurium systemic infection in Rwanda. Clinical features and treatment with cefotaxime |
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