The Effect of Ciprofloxacin on the Pharmacokinetic and ECG Parameters of Quinidine

Ciprofloxacin decreases the clearance of antipyrine and other drugs which, in part, undergo oxidative metabolism. Based on these findings, the authors hypothesized that ciprofloxacin may decrease the clearance of quinidine, a drug which also undergoes oxidative metabolism. The purpose of this study...

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Veröffentlicht in:	Journal of clinical pharmacology 1990-10, Vol.30 (10), p.911-915
Hauptverfasser:	Bleske, Barry E., Carver, Peggy L., Annesley, Thomas M., Bleske, Jane R. M., Morady, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Ciprofloxacin - administration & dosage Ciprofloxacin - pharmacology Electrocardiography - drug effects Half-Life Humans Male Quinidine - administration & dosage Quinidine - antagonists & inhibitors Quinidine - blood Quinidine - pharmacokinetics Random Allocation Time Factors
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